La Silla del Papa (Tarifa, Cádiz) : bilan de trois années de recherches

International audienceLes recherches engagées depuis 2007 sur le site de la Silla del Papa (Tarifa, province de Cadix, Espagne) ont mis au jour une importante agglomération perchée, probable berceau de la communauté d'origine bastulo-punique qui fonda, sous Auguste, la ville de Baelo. Ce site de hauteur, occupé du Xe au Ier siècle av. J.-C., a livré de nombreux vestiges d'un urbanisme singulier, conditionné en partie par des contraintes topographiques

Evaluation of Proton MR Spectroscopy for the Study of the Tongue Tissue in Healthy Subjects and Patients With Tongue Squamous Cell Carcinoma: Preliminary Findings

PurposeTo noninvasively assess spectroscopic and metabolic profiles of healthy tongue tissue and in an exploratory objective in nontreated and treated patients with tongue squamous cell carcinoma (SCC).MethodsFourteen healthy subjects (HSs), one patient with nontreated tongue SCC (NT-SCC), and two patients with treated tongue SCC (T-SCC) underwent MRI and single-voxel proton magnetic resonance spectroscopy (1H-MRS) evaluations (3 and 1.5T). Multi-echo-times 1H-MRS was performed at the medial superior part (MSP) and the anterior inferior part (AIP) of the tongue in HS, while 1H-MRS voxel was placed at the most aggressive part of the tumor for patients with tongue SCC. 1H-MRS data analysis yielded spectroscopic metabolite ratios quantified to total creatine.ResultsIn HS, compared to MSP and AIP, 1H-MRS spectra revealed higher levels of creatine, a more prominent and well-identified trimethylamine-choline (TMA-Cho) peak. However, larger prominent lipid peaks were better differentiated in the tongue MSP. Compared to HS, patients with NT-SCC exhibited very high levels of lipids and relatively higher values of TMA-Cho peak. Interestingly, patients with T-SCC showed almost nonproliferation activity. However, high lipids levels were measured, although they were relatively lower than lipids levels measured in patients with NT-SCC.ConclusionThe present study demonstrated the potential use of in-vivo1H-MRS to noninvasively assess spectroscopic and metabolic profiles of the healthy tongue tissue in a spatial location-dependent manner. Preliminary results revealed differences between HS and patients with tongue NT-SCC as well as tongue T-SCC, which should be confirmed with more patients. 1H-MRS could be included, in the future, in the arsenal of tools for treatment response evaluation and noninvasive monitoring of patients with tongue SCC

MetalAfrica: from dream to reality

International audienceAt SAfA 2012 in Toronto, the concept of MetalAfrica was presented by Caroline Robion-Brunner, the founder and president of this new association. She outlined the scope of MetalAfrica, as an open and easily accessible online platform, including a database, discussion group and blog aimed at providing a virtual community space for those researching metallurgy across the African continent. MetalAfrica was described as a facilitator of academic exchanges and collaborations between researchers from different institutions and countries working on the subject of African metallurgy, with one of its fundamental purposes, in addition to data sharing and accessibility, being to encourage networking and partnerships between the global communities of researchers including PhD students, junior and senior academics. It was proposed that the future widespread use of MetalAfrica will increase the diffusion of scientific knowledge and stimulate academic discussions, for example through publications and conferences. Comments and questions were on the whole positive and encouraging, with more than a hint of scepticism at such an enormous task.Throughout 2013 a team of people gathered to create the association and define the basis of the online platform. At the PAA/SAfA meeting in South Africa in 2014 we look forward to presenting the current state of MetalAfrica, including the structure and nature of the organisation, a demonstration of MetalAfrica.org and our plans for the coming years including the first biennial MetalAfrica meeting at SAfA 2016 in Toulouse. We will be providing early access to the website for those interested, and importantly gaining feedback based on this presentation that will help us as we finalise the format of the organisation and online platform

Introduction : Réseaux de transferts matériels, aires chronoculturelles : le visible et l’invisible

International audienc

Introduction : Réseaux de transferts matériels, aires chronoculturelles : le visible et l’invisible

International audienc

Principe et applicabilité de la chirurgie de précision aux cancers de la tête et du cou

La chirurgie est la modalité de traitement curatif la plus fréquemment utilisée dans les cancers de la tête et du cou. Elle est intégrée dans des schémas de stratification thérapeutique précis, mais la conduite de l’acte chirurgical et son évaluation ne tiennent, la plupart du temps, pas compte de la biologie tumorale. Nous présentons dans cette revue plusieurs études qui montrent comment les analyses de la biologie tumorale pourraient préciser les indications et le contour d’une résection chirurgicale, personnaliser la prise en charge péri-opératoire du patient, et faciliter la détection des récurrences tumorales. Ces études apportent ainsi une preuve de principe qu’une chirurgie de précision, c’est-à-dire adossée à la biologie tumorale, à la façon de la médecine de précision pour d’autres cancers, est applicable aux cancers de la tête et du cou

IMPORTANCE OF EARLY SPECTRAL VARIATIONS DURING A LONGITUDINAL 60-MONTH FOLLOW-UP MRI AND 1H-MRS IN 135 TREATED GLIOBLASTOMA PATIENTS

14th Meeting of the European-Association-of-Neuro-Oncology (EANO), Lyon, FRANCE, SEP 19-22, 2019International audienc