Neural Network Analysis of the Effects of Rainfall Variability and Groundwater Usage on the Hydrologic System in a Karst Terrain, Central Florida, USA

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Устойчивое водопотребление и геоэкологическая безопасность (на примере Западной Сибири)

Представлены результаты многолетних исследований факторов, определяющих состояние водных ресурсов, и тенденции изменения качества природных вод. Охарактеризованы элементы концепции обеспечения геоэкологической безопасности хозяйственно-питьевого водопотребления в Западной Сибири. Она учитывает естественно-природные (ландшафтно-климатические, гидрогеологические, экологические и др.), техногенные (эмиссия загрязняющих веществ, гидротехнические сооружения, добыча энергоресурсов и др.) и социально-экономические (уровень урбанизации, финансовое обеспечение и др.) факторы.The article deals with long-term studies of factors determining the state of water resources, and trends in the quality of natural water. The concept of providing geoecological safety of domestic and drinking water consumption in Western Siberia is described. It takes into account the natural (landscapeclimatic, hydro-geological, ecological, etc.), technogenic (emission of pollutants, hydraulic structures, extraction of energy resources, etc.) and socio-economic (level of urbanization, financial provision, etc.) factors

South Carolina Digital Flood Inundation Mapping Pilot Investigation

2012 S.C. Water Resources Conference - Exploring Opportunities for Collaborative Water Research, Policy and Managemen

A Product Formula for the Normalized Volume of Free Sums of Lattice Polytopes

The free sum is a basic geometric operation among convex polytopes. This note focuses on the relationship between the normalized volume of the free sum and that of the summands. In particular, we show that the normalized volume of the free sum of full dimensional polytopes is precisely the product of the normalized volumes of the summands.Comment: Published in the proceedings of 2017 Southern Regional Algebra Conferenc

Data Mining to Predict Climate and Groundwater Use Impacts on the Hydrology of Central Florida

2012 S.C. Water Resources Conference - Exploring Opportunities for Collaborative Water Research, Policy and Managemen

Mentoring in students' adaptation to labor market requirements

The article contains the analyzes of the problems of youth employment, the development of mentoring in Russia. The ways of their joint decision are proposed with the purpose of acquiring production experience, professional self-realization and increasing the competitiveness of future specialists

Levo-α-acetylmethadol (LAAM) induced QTc-prolongation - results from a controlled clinical trial

<p>Abstract</p> <p>Background</p> <p>Due to potential proarrhythmic side-effects levo-α-Acetylmethadol (LAAM) is currently not available in EU countries as maintenance drug in the treatment of opiate addiction. However, recent studies and meta-analyses underline the clinical advantages of LAAM with respect to the reduction of heroin use. Thus a reappraisal of LAAM has been demanded. The aim of the present study was to evaluate the relative impact of LAAM on QTc-interval, as a measure of pro-arrhythmic risk, in comparison to methadone, the current standard in substitution therapy.</p> <p>Methods</p> <p>ECG recordings were analysed within a randomized, controlled clinical trial evaluating the efficacy and tolerability of maintenance treatment with LAAM compared with racemic methadone. Recordings were done at two points: 1) during a run-in period with all patients on methadone and 2) 24 weeks after randomisation into methadone or LAAM treatment group. These ECG recordings were analysed with respect to QTc-values and QTc-dispersion. Mean values as well as individual changes compared to baseline parameters were evaluated. QTc-intervals were classified according to CPMP-guidelines.</p> <p>Results</p> <p>Complete ECG data sets could be obtained in 53 patients (31 LAAM-group, 22 methadone-group). No clinical cardiac complications were observed in either group. After 24 weeks, patients receiving LAAM showed a significant increase in QTc-interval (0.409 s ± 0.022 s versus 0.418 s ± 0.028 s, p = 0.046), whereas no significant changes could be observed in patients remaining on methadone. There was no statistically significant change in QTc-dispersion in either group. More patients with borderline prolonged and prolonged QTc-intervals were observed in the LAAM than in the methadone treatment group (n = 7 vs. n = 1; p = 0.1).</p> <p>Conclusions</p> <p>In this controlled trial LAAM induced QTc-prolongation in a higher degree than methadone. Given reports of severe arrhythmic events, careful ECG-monitoring is recommended under LAAM medication.</p

Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

<p>Abstract</p> <p>Background</p> <p>RC-101, a cationic peptide retrocyclin analog, has <it>in vitro </it>activity against HIV-1. Peptide drugs are commonly prone to conformational changes, oxidation and hydrolysis when exposed to excipients in a formulation or biological fluids in the body, this can affect product efficacy. We aimed to investigate RC-101 stability under several conditions including the presence of human vaginal fluids (HVF), enabling the efficient design of a safe and effective microbicide product. Stability studies (temperature, pH, and oxidation) were performed by HPLC, Circular Dichroism, and Mass Spectrometry (LC-MS/MS). Additionally, the effect of HVF on formulated RC-101 was evaluated with fluids collected from healthy volunteers, or from subjects with bacterial vaginosis (BV). RC-101 was monitored by LC-MS/MS for up to 72 h.</p> <p>Results</p> <p>RC-101 was stable at pH 3, 4, and 7, at 25 and 37°C. High concentrations of hydrogen peroxide resulted in less than 10% RC-101 reduction over 24 h. RC-101 was detected 48 h after incubation with normal HVF; however, not following incubation with HVF from BV subjects.</p> <p>Conclusions</p> <p>Our results emphasize the importance of preformulation evaluations and highlight the impact of HVF on microbicide product stability and efficacy. RC-101 was stable in normal HVF for at least 48 h, indicating that it is a promising candidate for microbicide product development. However, RC-101 stability appears compromised in individuals with BV, requiring more advanced formulation strategies for stabilization in this environment.</p