Susceptibility of White Spruce Seed Sources to Yellowheaded Spruce Sawfly, \u3ci\u3ePikonema Alaskensis,\u3c/i\u3e(Hymenoptera: Tenthredinidae)

A field caging technique was used to test the susceptibility of 25 white spruce, Picea glauca (Moench) Voss, seed sources to attack by Pikonema alaskensis (Rohwer). No sig- nificant differences were found in the number of eggs laid, number of dessicated eggs, or number of egg slits. Percent oviposition differed significantly within a tree, the south side having more eggs. Bud size differed significantly within trees and between trees but not between seed sources. The number of sawfly eggs laid on a bud could not be related to bud size. There was no significant difference in susceptibility of the seed sources studied to Pikonema alaskensis

Low altitude temperature and humidity profile data for application to aircraft noise propagation

A data search of the weather statistics from 11 widely dispersed geographical locations within the continental United States was conducted. The sites, located long both sea-coasts and in the interior, span the northern, southern, and middle latitudes. The weather statistics, retrieved from the records of these 11 sites, consist of two daily observations taken over a 10-year period. The data were sorted with respect to precipitation and surface winds and classified into temperature intervals of 5 C and relative humidity intervals of 10 percent for the lower 1400 meters of the atmosphere. These data were assembled in a statistical format and further classified into altitude increments of 200 meters. The data are presented as sets of tables for each site by season of the year and include both daily observations

Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate.

The colonial ascidian Botryllus schlosseri continuously regenerates entire bodies in an asexual budding process. The germ line of the newly developing bodies is derived from migrating germ cell precursors, but the signals governing this homing process are unknown. Here we show that germ cell precursors can be prospectively isolated based on expression of aldehyde dehydrogenase and integrin alpha-6, and that these cells express germ cell markers such as vasa, pumilio and piwi, as well as sphingosine-1-phosphate receptor. In vitro, sphingosine-1-phosphate (S1P) stimulates migration of germ cells, which depends on integrin alpha-6 activity. In vivo, S1P signalling is essential for homing of germ cells to newly developing bodies. S1P is generated by sphingosine kinase in the developing germ cell niche and degraded by lipid phosphate phosphatase in somatic tissues. These results demonstrate a previously unknown role of the S1P signalling pathway in germ cell migration in the ascidian Botryllus schlosseri

Noise characteristics of the O-1 airplane and some approaches to noise reduction

A brief study of the O-1A airplane to determine possible means for reducing the aircraft aural detection distance was conducted. This effort involved measuring the noise signature of the basic airplane, devising methods to attenuate the noise, and then estimating the effect of several selected modifications on the aural detection distance of the aircraft. A relatively simple modification utilizing a 6.5 ft diameter, six-blade propeller and including a muffler having a volume of 0.725 cu ft is indicated to reduce the aural detection distance of the O-1 aircraft from about 6 miles at an altitude of 1,000 ft and 2 to 3 miles at an altitude of 300 ft to approximately half these values. The flyover noise data suggest that routing the exhaust stacks up and over the wing would provide immediate noise reduction of about 5 dB with an attendant reduction in detection distance. Furthermore, all these studies confirm the work of other investigators that the 1/3 octave band (center frequency=125 cps) is the most critical in reducing aural detection distance

Noise reduction studies for the OV-1 airplane

A study has been conducted to define possible modifications to the OV-1 aircraft to reduce its aural detection distance. This effort involved documenting the noise characteristics of the airplane, devising modifications to reduce the noise, estimating the reduction in detection distance, and evaluating aircraft performance as a result of these modifications. It was found that the main noise source on this aircraft is the propeller and hence modifications only to the propeller and the propeller drive system are proposed. Modifications involving only the propeller are noted to involve no increase in weight but they result in only a modest decrease in aural detection distance. In order to obtain substantial decreases in aural detection distance, modifications involving changes both to the propeller and the engine-propeller gearing are required

Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder.

BackgroundWe evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with major depressive disorder.MethodsWe conducted a 6-week, double-blind, placebo-controlled, parallel-group, Phase II, proof-of-concept study. Patients with major depressive disorder (partial responders to ongoing antidepressant therapy) were randomized 1:1 to once-daily oral filorexant 10 mg or matching placebo.ResultsDue to enrollment challenges, the study was terminated early, resulting in insufficient statistical power to detect a prespecified treatment difference; of 326 patients planned, 129 (40%) were randomized and 128 took treatment. There was no statistically significant difference in the primary endpoint of change from baseline to week 6 in Montgomery Asberg Depression Rating Scale total score; the estimated treatment difference for filorexant-placebo was -0.7 (with negative values favoring filorexant) (P=.679). The most common adverse events were somnolence and suicidal ideation.ConclusionsThe interpretation of the results is limited by the enrollment, which was less than originally planned, but the available data do not suggest efficacy of orexin receptor antagonism with filorexant for the treatment of depression. (Clinical Trial Registry: clinicaltrials.gov: NCT01554176)