ECONOMIC FORCES INFLUENCING VALUE-ADDED FOOD INDUSTRIES: IMPLICATIONS FOR SOUTHERN AGRICULTURE

Agribusiness,

Black Rock A Tale of the Selkirks

https://commons.und.edu/settler-literature/1122/thumbnail.jp

On the size and complexity of scrambles

The scramble number of a graph, a natural generalization of bramble number, is an invariant recently developed to study chip-firing games and graph gonality. We introduce the carton number of a graph, defined to be the minimum size of a maximum order scramble, to study the computational complexity of scramble number. We show that there exist graphs with carton number exponential in the size of the graph, proving that scrambles are not valid NP certificates. We characterize families of graphs whose scramble number and gonality can be constant-factor approximated in polynomial time and show that the disjoint version of scramble number is fixed parameter tractable. Lastly, we find that vertex congestion is an upper bound on screewidth and thus scramble number, leading to a new proof of the best known bound on the treewidth of line graphs and a bound on the scramble number of planar graphs with bounded degree.Comment: 20 pages, 6 figure

Emerging Longitudinal Trends in Health Indicators for Rural Residents Participating in a Diabetes and Cardiovascular Screening Program in Northern Alberta, Canada

Background. Geographic isolation, poverty, and loss of culture/tradition contribute to “epidemic” rates of diabetes amongst indigenous Canadians. The Mobile Diabetes Screening Initiative travels to rural indigenous and other remote communities in Alberta to screen for diabetes and cardiovascular risk. We sought to examine risk factors longitudinally. Methods. Clinical and anthropometric measurements were undertaken for 809 adults (aged 20–91) between November 2003 and December 2009. For those who had more than one MDSi visit, trend estimates (actual changes) were calculated for body mass index (BMI), weight, waist circumference, hemoglobin A1c (A1c), total cholesterol, and blood pressure. Results. Among those without diabetes (N = 629), BMI and weight increased (P < .01) and blood pressure decreased (P < .05). For those with diabetes (N = 180), significant improvements (P < .05) were observed for all indicators except waist circumference. Conclusion. Improvements observed suggest that MDSi's model may effectively mediate some barriers and support subjects in managing their health

Quantification of Lansoprazole in Oral Suspension by Ultra-High-Performance Liquid Chromatography Hybrid Ion-Trap Time-of-Flight Mass Spectrometry

An LC-MS/MS method was developed and validated to be used as a stability indicating assay for the study of a 3 mg/mL lansoprazole oral suspension. The method utilizes a UPLC (ultra-performance liquid chromatography) column and unique mass spectrometric detection (ion-trap time-of-flight (IT-TOF)) to achieve a sensitive (LOD 2 ng/mL), accurate, and reproducible quantification of lansoprazole. This method reports an intraday and interday coefficient of variation of 2.98 ± 2.17% (n = 5 for each concentration for each day) and 3.07 ± 0.89% (n = 20 for each concentration), respectively. Calibration curves (5–25 μg/mL) were found to be linear with an R2 value ranging from 0.9972 to 0.9991 on 4 different days. Accuracy of the assay, expressed as % error, ranged from 0.30 to 5.22%. This method is useful for monitoring the stability of lansoprazole in oral suspension

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly

KEAP1 promotes the ubiquitin-dependent degradation of NRF2 by assembling into a CUL3-dependent ubiquitin ligase complex. Oxidative and electrophilic stress inhibit KEAP1 allowing NRF2 to accumulate for the transactivation of stress response genes. To date there are no structures of the KEAP1-CUL3 interaction nor binding data to show the contributions of different domains to their binding affinity. We determined a crystal structure of the BTB and 3-box domains of human KEAP1 in complex with the CUL3 N-terminal domain that showed a heterotetrameric assembly with 2:2 stoichiometry. To support the structural data, we developed a versatile TR-FRET-based assay system to profile the binding of BTB-domain-containing proteins to CUL3 and determine the contribution of distinct protein features, revealing the importance of the CUL3 N-terminal extension for high affinity binding. We further provide direct evidence that the investigational drug CDDO does not disrupt the KEAP1-CUL3 interaction, even at high concentrations, but reduces the affinity of KEAP1-CUL3 binding. The TR-FRET-based assay system offers a generalizable platform for profiling this protein class and may form a suitable screening platform for ligands that disrupt these interactions by targeting the BTB or 3-box domains to block E3 ligase function

Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells

Previous results link the mitochondrial potassium channel Kv1.3 (mitoKv1.3) to the regulation of apoptosis. By synthesizing new, mitochondria-targeted derivatives (PAPTP and PCARBTP) of PAP-1, a specific membrane-permeant Kv1.3 inhibitor, we have recently provided evidence that both drugs acting on mitoKv1.3 are able to induce apoptosis and reduce tumor growth in vivo without affecting healthy tissues and cells. In the present article, by exploiting these new drugs, we addressed the question whether mitoKv1.3 contributes to the regulation of cell proliferation as well. When used at low concentrations, which do not compromise cell survival, both drugs slightly increased the percentage of cells in S phase while decreased the population at G0/G1 stage of cells from two different pancreatic ductal adenocarcinoma lines. Our data suggest that the observed modulation is related to ROS levels within the cells, opening the way to link mitochondrial ion channel function to downstream, ROS-related signaling events that might be important for cell cycle progression

One future or many? November 14, 15, and 16, 2002

This repository item contains a single issue of the Pardee Conference Series, a publication series that began publishing in 2006 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future. This was the Center's 2nd annual Conference that took place during November 14, 15, and 16, 2002.The conference brought together some 30 experts from various disciplines to discuss whether the trajectories of the future will be ‘global’ or ‘regional’ in nature. Different panels looks at the future trajectories for Europe, the Western Hemisphere, Central Asia and the Former Soviet Union, and on Asia and in each case the discussion looked at the relative importance of the regional and of global dynamics on teh forces shaping the future of these regions.Carnegie Council on Ethics and International Affair

Pennsylvania Folklife Vol. 37, No. 1

• Franklin in Fact and Fiction: The Double Perspective of Leland Baldwin • Jost Hite: From the Neckar to the Shenandoah • The Migration and Settlement of Pennsylvania Germans in Maryland, Virginia and North Carolina and Their Effects on the Landscape • Bethesda Evangelical Church in Farmers Mills: Fact and Folklore • The Tourist Bureau Shuns Me!https://digitalcommons.ursinus.edu/pafolklifemag/1117/thumbnail.jp