China – ICC arbitration in China

Letter from barrister Anthony Connerty describing one of the few international commercial arbitration hearings to be held in China under the Rules of the International Chamber of Commerce which took place in Beijing in February 1999. Published in the Letter from … section of Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

RNA Binding Proteins in the miRNA pathway

© 2015 by the authors; licensee MDPI, Basel, Switzerland. microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets

The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells

© 2016 Elsevier B.V. MicroRNAs (miRNAs) are short (21–23 nt long) RNAs that post-transcriptionally regulate gene expression in plants and animals. They are key regulators in all biological processes. In mammalian cells miRNAs are loaded into one of the four members of the Argonaute (Ago) protein family to form the RNA-induced silencing complex (RISC). RISCs inhibit the translation of mRNAs that share sequence complementarity with their loaded miRNAs. miRNA processing and miRNA-mediated gene regulation are highly regulated processes and involve many RNA-binding proteins as auxiliary factors. Here we show that the two RNA-binding proteins, p72 and KHSRP, both with known roles in promoting miRNA biogenesis, regulate the protein level of human Ago2 in transformed human cells. We determined that p72 and KHSRP influence Ago2 stability by regulating miRNA levels in the cell and that loss of p72/KHSRP results in a decrease of unloaded Ago2

Resolving the resource nationalism struggle

Commentary by Anthony Connerty (Head of the IDR Group) on the control of national resources and the challenges for international dispute resolution. Published in Amicus Curiae – Journal of the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies. The Journal is produced by SALS at the IALS (Institute of Advanced Legal Studies, School of Advanced Study, University of London)

The credit crunch: the collapse of Lehman Brothers - and a Hong Kong scheme to handle Lehman claims

Anthony Connerty (Barrister and Chartered Arbitrator) looks at the Lehman collapse - considering the background to the collapse of Lehman Brothers investment bank, claims related to the collapse, an example of a credit crunch claim, a criminal prosecution and a Hong Kong mediation and arbitration scheme aimed at dealing speedily with Lehman Brothers-related claims. Versions of this article have been published in Hong Kong in the January 2010 edition of Asian Dispute Review and in London in the July 9, 2010 edition of New Law Journal. Published in Amicus Curiae – Journal of the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies. The Journal is produced by SALS at the IALS (Institute of Advanced Legal Studies, School of Advanced Study, University of London)

The spread of international arbitration: a survey based on views expressed in leading textbooks

Anthony Connerty (Barrister and Chartered Arbitrator) looks at the treatment of international arbitration in four major works, and considers the views expressed by the authors, editors and contributors on the spread of the use of international arbitration. The works considered are: Redfern and Hunter on International Arbitration; International Commercial Arbitration, by Gary B. Born; Arbitration in Asia, edited by Michael Moser; International Commercial Arbitration in New York, edited by James H. Carter and John Fellas

Resolving trade disputes with China

Anthony Connerty, barrister and member of several international arbitration panels considers the advantages of arbitration in the resolution of disputes arising under international trading contracts. Published in Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

The internet era: the development of electronic commerce in China – and a need for global dispute resolution processes

Article examining the development of electronic commerce worldwide, particularly in China, as well as the problems of dispute resolution in the context of electronic commerce. Article by Anthony Connerty (Barrister, Lamb Chambers, Temple, London; consultant to the French law firm of Cabinet Sefrioui, Paris). Published in Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

Three Theories of Development: A Comparison of Dewey, Kohlberg, and Noddings\u27 Models of Moral Growth

This paper will compare the moral theories developed by John Dewey, Lawrence Kohlberg, and Nel Noddings to discern places of agreement and areas of dispute. The paper will also examine the most consequential ethical formulations of the three thinkers. For Dewey it is his conception of conscientiousness. For Kohlberg it is the idea of justice. Lastly, for Noddings it is the virtue of empathy found in the caring response. These conceptions are the foundations of their moral ideas. They color their thoughts on such related topics as the objective versus subjective nature of morality, the role of the rational and the emotional faculties in decision making, and the elements of moral judgment. This paper will examine where Dewey, Kohlberg, and Noddings stand on these issues and how they compare and contrast with each other. Their theories present an insightful glimpse into the entirety and diversity of the moral nature that informs the human condition

Pollination ecology of the invasive tree tobacco nicotiana glauca: comparisons across native and non-native ranges

Interactions with pollinators are thought to play a significant role in determining whether plant species become invasive, and ecologically generalised species are predicted to be more likely to invade than more specialised species. Using published and unpublished data we assessed the floral biology and pollination ecology of the South American native Nicotiana glauca (Solanaceae) which has become a significant invasive of semi-arid parts of the world. In regions where specialised bird pollinators are available, for example hummingbirds in California and sunbirds in South Africa and Israel, N. glauca interacts with these local pollinators and sets seed by both outcrossing and selfing. In areas where there are no such birds, such as the Canary Islands and Greece, abundant viable seed is set by selfing, facilitated by the shorter stigma-anther distance compared to plants in native populations. Surprisingly, in these areas without pollinating birds, the considerable nectar resources are only rarely exploited by other flower visitors such as bees or butterflies, either legitimately or by nectar robbing. We conclude that Nicotiana glauca is a successful invasive species outside of its native range, despite its functionally specialised hummingbird pollination system, because it has evolved to become more frequently self pollinating in areas where it is introduced. Its invasion success is not predictable from what is known of its interactions with pollinators in its home range.Fil: Ollerton, Jeff. University of Northampton. School of Science and Technology. Landscape and Biodiversity Research Group; Reino UnidoFil: Watts, Stella. University of Northampton. School of Science and Technology. Landscape and Biodiversity Research Group; Reino UnidoFil: Connerty, Shawn. University of Northampton. School of Science and Technology. Landscape and Biodiversity Research Group; Reino UnidoFil: Lock, Julia. University of Northampton. School of Science and Technology. Landscape and Biodiversity Research Group; Reino UnidoFil: Parker, Leah. University of Northampton. School of Science and Technology. Landscape and Biodiversity Research Group; Reino UnidoFil: Wilson, Ian. University of Northampton. School of Science and Technology. Landscape and Biodiversity Research Group; Reino UnidoFil: Schueller, Sheila K.. University of Michigan. School of Natural Resources and Environment; Estados UnidosFil: Nattero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Cocucci, Andrea Aristides. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Izhaki, Ido. University of Haifa. Faculty of Science and Science Education. Department of Evolutionary and Environmental Biology; IsraelFil: Geerts, Sirjk. Stellenbosch University. Department of Botany and Zoology; SudáfricaFil: Pauw, Anton. Stellenbosch University. Department of Botany and Zoology; SudáfricaFil: Stout, Jane C.. Trinity College Dublin. Trinity Centre for Biodiversity Research and School of Natural Sciences, Trinity College Dublin; Reino Unid