Numerical analysis of four-wave mixing between 2 ps mode-locked laser pulses in a tensile-strained bulk SOA

A numerical model of four-wave mixing between 2-ps pulses in a tensile-strained bulk semiconductor optical amplifier is presented. The model utilizes a modified Schrodinger equation to model the pulse propagation. The Schrodinger equation parameters such as the material gain first and second order dispersion, linewidth enhancement factors and optical loss coefficient are obtained using a previously developed steady-state model. The predicted four-wave mixing pulse characteristics show reasonably good agreement with experimental pulse characteristics obtained using frequency resolved optical gating

Numerical analysis of pulse pedestal and dynamic chirp formation on picosecond modelocked laser pulses after propagation through a semiconductor optical amplifier

A numerical analysis, based on a modified Schrodinger equation, of the formation of pulse pedestals and dynamic chirp formation on picosecond pulses after propagation through a semiconductor optical amplifier is presented. The numerical predictions are confirmed by an experiment that utilises the frequency resolved optical gating technique for the amplified pulse characterisation

Triple-wavelength fiber ring laser based on a hybrid gain medium actively mode-locked at 10 GHz

A fiber ring laser based on a hybrid gain medium that produces three simultaneously mode-locked wavelength channels is presented. The lithium niobate based modulator used to actively mode-lock the laser cavity at 10 GHz is birefringence compensated to reduce its polarization sensitivity. A Lyot filter defines the lasers multiwavelength spectrum which has a wavelength spacing of 1 nm. The polarization sensitive nature of the laser cavity and its affect on the performance of the laser is discussed

Influence of co - and counter-propagating light on the phase-mismatch effect in semiconductor optical amplifiers

peer-reviewedThe phase-mismatch effect, caused by the difference in confinement factor between transverse electric (TE) and transverse magnetic (TM) modes, has not been observed in semiconductor optical amplifiers (SOAs) and is not typically accounted for. In this work, we investigate the characteristics of the phase-mismatch four wave mixing (FWM) effect, which occurs in SOA devices. Our results reveal a sinc-like response in the intensity of co- and counter-FWM conjugates as a function of the detuning shift between interacting beams. It is demonstrated that the coherence lengths between the phase match/mismatch cycles differ between co- and counter-propagating nondegenerate FWM experiments and depend on the amplified TE/TM polarizations of interacting waves aligned with respect to the birefringent axes of SOAs. The coherence lengths between each phase match/mismatch cycle in co-propagation experiments are found to be 1600 and infinite GHz, respectively, compared to 800 and 400 GHz found in counter-propagation experiments.ACCEPTEDpeer-reviewe

Proposing a Pedigree Risk Measurement Strategy: Capturing the Intergenerational Transmission of Antisocial Behavior in a Nationally Representative Sample of Adults

An impressive literature has revealed that variation in virtually every measurable phenotype is the result of a combination of genetic and environmental influences. Based on these findings, studies that fail to use genetically informed modeling strategies risk model misspecification and biased parameter estimates. Twin- and adoption-based research designs have frequently been used to overcome this limitation. Despite the many advantages of such approaches, many available datasets do not contain samples of twins, siblings or adoptees, making it impossible to utilize these modeling strategies. The current study proposes a measurement strategy for estimating the intergenerational transmission of antisocial behavior (ASB) within a nationally representative sample of singletons using an extended pedigree risk approach that relies on information from first- and second-degree relatives. An evaluation of this approach revealed a pattern of findings that directly aligned with studies examining ASB using more traditional twin- and adoption-based research designs. While the proposed pedigree risk approach is not capable of effectively isolating genetic and environmental influences, this overall alignment in results provides tentative evidence suggesting that the proposed pedigree risk measure effectively captures genetic influences. Future replication studies are necessary as this observation remains preliminary. Whenever possible, more traditional quantitative genetic methodologies should be favored, but the presented strategy remains a viable alternative for more limited samples

Resistant starch and protein intake enhances fat oxidation and feelings of fullness in lean and overweight/obese women

BACKGROUND: Diets high in either resistant starch or protein have been shown to aid in weight management. We examined the effects of meals high in non-resistant or resistant starch with and without elevated protein intake on substrate utilization, energy expenditure, and satiety in lean and overweight/obese women. METHODS: Women of varying levels of adiposity consumed one of four pancake test meals in a single-blind, randomized crossover design: 1) waxy maize (control) starch (WMS); 2) waxy maize starch and whey protein (WMS+WP); 3) resistant starch (RS); or 4) RS and whey protein (RS+WP). RESULTS: Total post-prandial energy expenditure did not differ following any of the four test meals (WMS = 197.9 ± 8.9; WMS+WP = 188 ± 8.1; RS = 191.9 ± 8.9; RS+WP = 195.8 ± 8.7, kcals/180 min), although the combination of RS+WP, but not either intervention alone, significantly increased (P <0.01) fat oxidation (WMS = 89.5 ± 5.4; WMS+WP = 84.5 ± 7.2; RS = 97.4 ± 5.4; RS+WP = 107.8 ± 5.4, kcals/180 min). Measures of fullness increased (125 % vs. 45 %) and hunger decreased (55 % vs. 16 %) following WP supplemented versus non-whey conditions (WMS+WP, RS+WP vs. WMS, RS), whereas circulating hunger and satiety factors were not different among any of the test meals. However, peptide YY (PYY) was significantly elevated at 180 min following RS+WP meal. CONCLUSIONS: The combined consumption of dietary resistant starch and protein increases fat oxidation, PYY, and enhances feelings of satiety and fullness to levels that may be clinically relevant if maintained under chronic conditions. This trial was registered at clinicaltrials.gov as NCT02418429

Toward an interactive article: integrating journals and biological databases.

BACKGROUND: Journal articles and databases are two major modes of communication in the biological sciences, and thus integrating these critical resources is of urgent importance to increase the pace of discovery. Projects focused on bridging the gap between journals and databases have been on the rise over the last five years and have resulted in the development of automated tools that can recognize entities within a document and link those entities to a relevant database. Unfortunately, automated tools cannot resolve ambiguities that arise from one term being used to signify entities that are quite distinct from one another. Instead, resolving these ambiguities requires some manual oversight. Finding the right balance between the speed and portability of automation and the accuracy and flexibility of manual effort is a crucial goal to making text markup a successful venture. RESULTS: We have established a journal article mark-up pipeline that links GENETICS journal articles and the model organism database (MOD) WormBase. This pipeline uses a lexicon built with entities from the database as a first step. The entity markup pipeline results in links from over nine classes of objects including genes, proteins, alleles, phenotypes and anatomical terms. New entities and ambiguities are discovered and resolved by a database curator through a manual quality control (QC) step, along with help from authors via a web form that is provided to them by the journal. New entities discovered through this pipeline are immediately sent to an appropriate curator at the database. Ambiguous entities that do not automatically resolve to one link are resolved by hand ensuring an accurate link. This pipeline has been extended to other databases, namely Saccharomyces Genome Database (SGD) and FlyBase, and has been implemented in marking up a paper with links to multiple databases. CONCLUSIONS: Our semi-automated pipeline hyperlinks articles published in GENETICS to model organism databases such as WormBase. Our pipeline results in interactive articles that are data rich with high accuracy. The use of a manual quality control step sets this pipeline apart from other hyperlinking tools and results in benefits to authors, journals, readers and databases.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Investigation of noise suppression, pulse intensity and chirp of an actively mode-locked semiconductor fiber ring laser

An actively mode-locked fiber ring laser that utilizes an EDFA and semiconductor optical amplifier (SOA) is presented. The SOA enhances noise suppression. Active mode-locking was demonstrated at repetition rates up to 20 GHz. The effects of intra-cavity power and SOA current on noise suppression are studied for two types of commercially available SOA. The frequency resolved optical gating technique is used to characterize the output pulse stream intensity and frequency chirp