A Pilot Study of the Thymus of Propylthiouracil-treated Rats

A study of the effects of propylthiouracil on the rat thymus showed histological changes in that tissue. The overall weight of the thymus tissue was reduced in comparison to the thymus weight of the control group. Histologically the thymus of the PTU group showed decreased width in the cortex with fewer lymphocytes and thymic corpuscles in the medullary portion. There appeared to be an intermediate area between the cortex and medulla rather than the distinct demarcation seen between the cortex and medulla of the normal rat thymus. The results observed in these tissues may indicate a retardation in the maturation of the thymus rather than thymic involution. Further histological studies must be made on the changes of the normal rat thymus from birth to adulthood in order to determine the extent of deviation from normal thymic growth as was observed in this experiment

The Whence and Whither of Man: A brief history of his origin and development through conformity to environment, being the Morse lectures (at Union Theological Seminary) for 1895

n/

Coronavirus Cures and the Courts

The coronavirus pandemic has drastically affected nearly every aspect of American life. Unfortunately, it has also created an opportunity for those willing to exploit vulnerable citizens by selling fake “cures.” This Article analyzes a lawsuit against televangelist Jim Bakker for doing just that. This Article also calls for increased protection for individuals when a global health pandemic and national emergency have been declared. This Article advocates a novel proposal—the enacting of a federal statute making it a felony for an individual to knowingly sell a fraudulent cure for any disease that has been designated a pandemic by the World Health Organization and in which the President of the United States has designated a national emergency. The following federal criminal statute is proposed: Whoever, having devised or intending to devise any scheme or artifice to defraud, for the express knowing purpose of obtaining money or property by means of false or fraudulent pretenses, representations, or promises of a cure for a disease designated by the World Health Organization as a global pandemic and designated by the President of the United States as a national emergency pursuant to the provisions of the National Emergencies Act, shall be fined not more than $2,000,000 or imprisoned not more than 50 years, or both. This potent statute will help deter individuals such as Jim Bakker from fraudulently selling “cures” during a pandemic crisis. Additionally, it will serve as a preventative measure in limiting the spread of a deadly pandemic disease such as coronavirus

Persistent financial hardship, 11-year weight gain, and health behaviors in the Whitehall II study.

OBJECTIVE: To ascertain prospectively gender-specific associations between types and amounts of financial hardship and weight gain, and investigate potential behavioral mechanisms. METHODS: Prospective study of 3701 adult British civil servants with repeated measures of difficulty paying bills or insufficient money to afford adequate for food/clothing (1985-1988; 1989-1990; 1991-1993; 1997-1999), and weight (1985-1988; 1997-1999). RESULTS: Persistent hardships were associated with adjusted mean weight change in women over 10.9 years, but no consistent pattern was seen in men. During follow-up, 46% of women gained ≥5 kg. Women reporting persistent insufficient money for food/clothing had a significantly greater odds of gaining ≥5 kg (1.42 [1.05, 1.92]) compared to no hardship history, which remained after socioeconomic status (SES) adjustment (1.45 [1.05, 2.01]). The association between persistent difficulty paying bills and odds of excess weight gain was also significant (1.42 [1.03, 1.97]) but attenuated after considering SES (1.39 [0.98, 1.97]). Four health behaviors as single measures or change variables did not attenuate associations. CONCLUSIONS: Results suggested strategies to tackle obesity must address employed women's everyday financial troubles which may influence weight through more biological pathways than classical correlates of economic disadvantage and weight.This is the final version, originally published in the journal Obesity here: http://onlinelibrary.wiley.com/doi/10.1002/oby.20875/abstract;jsessionid=EDA4F761217B492D16E7384EB67A7399.f02t02

Cutaneous Blood Flow and Percutaneous Absorption: A Quantitative Analysis Using a Laser Doppler Velocimeter and a Blood Flow Meter

Cutaneous blood flow has been directly quantitated in vivo for the first time without animal death utilizing the rat skin sandwich flap. This was accomplished by conducting experiments that made a direct correlation between two instruments: a laser Doppler velocimeter and an electromagnetic blood flow meter. Data demonstrate that the correlation between these two instruments is high and reproducible (r = 0.96) with a small (1.3%) coefficient of variation. Blood flow to skin in the unmanipulated state varies from 0.7 to 1.2 mls/min in an anesthetized rat. Application of the blood flow correlation to the determination of percutaneous absorption of caffeine across human skin and benzoic acid across rat skin demonstrates that assuming cutaneous blood flow is a particular value day to day in any skin type results in an apparent wide range of total compound absorbed across that skin on independent occasions. Utilizing actual blood flow measurements to calculate the amount of chemical absorbed reduces the range of variability in the total amount of chemical absorbed and provides a more accurate knowledge of events occurring during a particular time of the absorption process. Quantitation of cutaneous blood flow will be useful in physiologic and pharmacologic studies where actual cutaneous blood flow is likely to be important to the processes studied, e.g., delivery of drug to skin, metabolism within the skin, and disposition of drug to blood and skin following topical drug application

Gender and the double burden of economic and social disadvantages on healthy eating: cross-sectional study of older adults in the EPIC-Norfolk cohort

Abstract Background Multiple economic factors and social relationships determine dietary behaviours, but the inter-relations between determinants is unknown. Whether women and men differ in the vulnerability to, and impact of, combined disadvantages is also unclear. We examined associations between diverse combinations of economic resources and social relationships, and healthy eating in British older women and men. Methods Our sample comprised 9,580 over-50s (47 % of over-50 respondents) in the EPIC-Norfolk cohort study. We examined six economic factors (education, social class, home-ownership, money for needs, frequency of insufficient money for food/clothing, paying bills) and three social relationships (marital status, living arrangement and friend contact), independently and in combination, in relation to fruit variety and vegetable variety. We analysed gender-specific associations using multivariable linear regression with interaction terms. Results Lower social class, lower education, and difficulty paying bills were associated with lower fruit and vegetable variety in both genders, independent of social relationships. All social relationships were independently associated with fruit variety in men and with vegetable variety in both genders. Substantially lower variety was found for all combinations of low economic resources and lack of social relationship than for either measure alone, with men faring worse in the majority of combined disadvantages. For example, the difference in vegetable variety for men reporting low social class and non-married was much greater (β -4.1, [-4.8, -3.4]), than the independent association of low social class (β -1.5, [-1.8,–1.2]), or non-married (β -1.8, [-2.3,–1.3]). Variety was also lower among men with high economic resources but non-married or lone-living. Conclusion A double burden of low economic resources and lack of social relationships suggested they are unique joint determinants, particularly in older men, and that public health efforts to improve healthy eating would offer most benefit to older adults with intersecting economic and social disadvantages