LH level on the antagonist administration day as a predictor of the reproductive outcomes in women with normal ovarian function

IntroductionThe addition of antagonists is mainly based on estrogen level and follicle size, while LH level has not received sufficient attention.In this study, LH Level on the antagonist administration day was used as the main research objective to explore its relationship with laboratory indicators and pregnancy outcomes.Methods and AnalysisWe enrolled 854 patients with normal ovarian function undergoing in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) between May 2021 to May 2022 at the Reproductive Center of Shandong University of Traditional Chinese Medicine.We used the quartile method to group LH levels on the antagonist administration day. There were four groups: Q1 (0.53IU/L≤LH ≤ 1.89IU/L); Q2 (1.89IU/L<LH ≤ 3.01IU/L); Q3 (3.01IU/L<LH≤ 5.29 IU/L); Q4 (5.29IU/L<LH ≤ 8.72IU/L). A total of 452 fresh embryo transplantation cycles and 1726 Frozen embryo transplantation cycles were carried out.ResultThere were significant differences among the four groups in terms of total Gn dosage, E2, P and LH on trigger day, number of retrieved oocytes, number of 2PN embryos, number of blastocysts, Number of ET and fresh ETR.There is a significant correlation between LH on antagonist administration day and Basal LH Level,LH on trigger day,number of oocytes retrieved,number of 2PN embryos,number of blastocysts, number of ET.Using Fresh ETR,Fresh CPR,OHSS and Cumulative CPR as the criterion respectively, the optimal cut-off value for evaluating LH on antagonist administration day was 4.18IU/L,3.99IU/L,4.63IU/L,4.66IU/L.ConclusionThere was a significant positive correlation between LH on the antagonist administration day and number of oocytes retrieved,number of 2PN embryos,number of blastocysts.LH on the antagonist administration day could predict Fresh CPR,OHSS and Cumulative CPR to some extent

一酸化窒素の低下はナトリウムークロール共輸送体を活性化し、食塩感受性高血圧を発症させる

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 小室 一成, 東京大学教授 栗原 裕基, 東京大学講師 濱崎 敬文, 東京大学講師 森田 啓行, 東京大学特任准教授 宇野 漢成University of Tokyo(東京大学

Parrot Captions Teach CLIP to Spot Text

Despite CLIP being the foundation model in numerous vision-language applications, the CLIP suffers from a severe text spotting bias. Such bias causes CLIP models to `Parrot' the visual text embedded within images while disregarding the authentic visual semantics. We uncover that in the most popular image-text dataset LAION-2B, the captions also densely parrot (spell) the text embedded in images. Our analysis shows that around 50% of images are embedded with visual text content, and around 30% of captions words are in these embedded visual content. Based on such observation, we thoroughly inspect the different released versions of CLIP models and verify that the visual text is the dominant factor in measuring the LAION-style image-text similarity for these models. To examine whether these parrot captions shape the text spotting bias, we train a series of CLIP models with LAION subsets curated by different parrot-caption-oriented criteria. We show that training with parrot captions easily shapes such bias but harms the expected visual-language representation learning in CLIP models. This suggests that it is urgent to revisit either the design of CLIP-like models or the existing image-text dataset curation pipeline built on CLIP score filtering.Comment: project page: https://linyq17.github.io/CLIP-Parrot-Bias/. Add more analysis and ablation studies. Update Figure 3 with a more precise metri

Case Report: A novel mutation in TNFAIP3 in a patient with type 1 diabetes mellitus and haploinsufficiency of A20

BackgroundHaploinsufficiency of A20 (HA20) is a monogenic autosomal-dominant genetic autoinflammatory disease caused by loss of function mutations in the TNFAIP3 gene. The predominant autoimmune phenotype associated with HA20 varies significantly, presenting with fever, recurrent oral and genital ulcers, skin rash, gastrointestinal and musculoskeletal symptoms, and other clinical manifestations, all of which indicate an early-onset of autoinflammatory disorder. Genetic linkage between TNFAIP3 and T1DM was reported in GWAS studies. However, only a few cases of HA20 combined with T1DM have been reported.Case descriptionA 39-year-old man with a history of type 1 diabetes mellitus since 19 years was admitted to the Department of Endocrinology and Metabolism, First Affiliated Hospital of China Medical University. He also suffered from recurring and minor mouth ulcers since early childhood. His laboratory evaluation results revealed reduced islet function, normal lipid profile, HbA1c of 7%, elevated glutamate decarboxylase antibodies, elevated hepatic transaminases, and elevated thyroid-related antibodies with normal thyroid function. Notably, the patient was diagnosed in adolescence and never had ketoacidosis, the islets were functioning despite the long disease duration, his abnormal liver function could not be reasonably explained, and he had early onset Behcet’s-like disease symptom. Hence, although he was on routine follow-up for diabetes, we communicated with him and obtained consent for genetic testing. Whole-exome sequencing revealed a novel c.1467_1468delinsAT heterozygous mutation in the gene TNFAIP3, which is located in exon 7, resulting in a stop-gained type mutation p.Q490*. With good but mild fluctuating glycemic control, the patient received intensive insulin therapy with long-acting and short-acting insulin. The liver function was improved by using ursodeoxycholic acid 0.75 mg/d during the follow-up.ConclusionWe report a novel pathogenic mutation in TNFAIP3 that results in HA20 in a patient with T1DM. In addition, we analyzed the clinical feathers of such patients and summarized the cases of five patients with HA20 co-presented with T1DM. When T1DM co-occurs with autoimmune diseases or other clinical manifestations, such as oral and/or genital ulcers and chronic liver damage, the possibility of an HA20 must be considered. Early and definitive diagnosis of HA20 in such patients may inhibit the progression of late-onset autoimmune diseases, including T1DM

Can land transfer relax credit constraints? Evidence from China

Although many studies have examined what drives credit constraints and their negative impact, evidence on the mechanism of relaxing credit constraints is scarce. This paper explores effective solutions to help households improve their access to credit. Using the China Family Panel Studies data from 2018, we employ an endogenous switching probit model to examine whether and to what extent land transfer can ease credit constraints. We find that households that transfer their land in or out are, respectively, 31.4% or 21.4% less credit constrained than those that do not. Participation in land transfers can improve borrowers’ financial situations through income increases and pledging assets as collateral, alleviating both formal and informal credit constraints. Our results suggest that any government initiatives to promote the efficiency of land transfer to ease credit constraints can help boost economic growth in China

Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis

<p>Abstract</p> <p>Background</p> <p>All aerobically grown living cells are exposed to oxidative damage by reactive oxygen species (ROS). A major damage by ROS to proteins is caused by covalent modifications of methionine residues giving methionine sulfoxide (Met-SO). Methionine sulfoxide reductases are enzymes able to regenerate methionine and restore protein function after oxidative damage.</p> <p>Results</p> <p>We characterized the methionine sulfoxide reductase genes <it>msrA </it>and <it>msrB </it>in <it>Bacillus subtilis</it>, forming an operon transcribed from a single sigma A-dependent promoter. The <it>msrAB </it>operon was specifically induced by oxidative stress caused by paraquat (PQ) but not by H₂O₂. Spx, a global oxidative stress regulator in <it>B. subtilis</it>, is primarily responsible for this PQ-specific induction of <it>msrAB </it>expression. In support of this finding, an <it>spx </it>deletion mutant is extremely sensitive to PQ, and increased expression of <it>msrA </it>was identified in a <it>clpX </it>mutant in which Spx accumulated. However, the Spx effect was also visible under conditions where the protein did not accumulate (PQ treatment), suggesting a specific molecular effect at the level of the Spx protein. Indeed, the CXXC motif of Spx was found essential for its function in the PQ-specific induction of <it>msrAB </it>expression. PQ caused a modification of Spx requiring at least one of the cysteines of the CXXC motif of Spx. The PQ modified form of Spx showed a dynamic change <it>in vivo</it>.</p> <p>Conclusion</p> <p>The Spx mediated PQ-specific regulation pathway of the <it>msrAB </it>operon in <it>B. subtilis </it>is reported. Our results suggest that PQ induced the expression of <it>msrAB </it>partially through an oxidation on Spx via modification of its CXXC motif.</p