5 research outputs found
Fecal Short Chain Fatty Acids and Dietary Intake in Italian Women With Restrictive Anorexia Nervosa: A Pilot Study
Nutritional disorders such as Anorexia Nervosa (AN) can shape the composition of gut microbiota and its metabolites such as short chain fatty acid (SCFA). This study aims to compare fecal SCFA along with dietary intake of women with restrictive AN (r-AN = 10) and those of sex-matched lean controls (C = 8). The main fecal short chain fatty acids (SCFA) were assessed by gas chromatography equipped with a flame ionization detector. All participants completed 7-day food record and underwent indirect calorimetry for measuring resting energy expenditure (REE). Butyrate and propionate fecal concentrations were significantly reduced in r-AN patients compared to controls. The intake of carbohydrate and fat was significantly lower in r-AN patients than controls as well as energy intake and REE; whereas the amount of protein and fiber did not differ between groups. These preliminary results showed that r-AN patients had a reduced excretion of fecal SCFA, likely as a mechanism to compensate for the lower energy and carbohydrate intake observed between groups. Therefore, further studies need to be performed in patients with AN to explore the link between nutritional disorders, gut microbiota and its metabolites
MICROBIOTA INTESTINALE, ENTEROORMONI, ALCUNE CITOKINE PRO-INFIAMMATORIE IN DIFFERENTI CONDIZIONI NUTRIZIONALI (INFLUENZA SU ALCUNI PARAMETRI CLINICI, BIOCHIMICI E FUNZIONALI)
Il nostro studio si propone di valutare le possibili correlazioni esistenti tra gli Acidi Grassi a Catena Corta fecali (SCFA) prodotti dal microbiota intestinale, la struttura epatica valutata con ultrasonografia, alcuni parametri espressione del metabolismo, alcuni enterormoni e citochine, in 4 gruppi di pazienti differenti per lo stato nutrizionale ed in un gruppo controllo
Intestinal microbiota in adult patients with Short Bowel Syndrome: Preliminary results from a pilot study
Introduction: Intestinal bacterial flora plays a central role in human intestinal health and disease. Short Bowel Syndrome (SBS), a clinical condition deriving from extensive bowel resections, influence intestinal microbiota (IM) composition in order to reach a new metabolic balance. Little is known about IM in adult patients after wide intestinal resections. Material and methods: Fecal samples from 12 SBS patients and 16 controls were analyzed in their microbial profile by using both culture-dependent method and quantitative Real-Time PCR (qRT-PCR). Results: The two methods revealed significant lower concentrations of . Bacteroidetes (p-value = .02), . Firmicutes (p-value = .05), . Bifidobacterium (p-value < .01), and . Methanobrevibacter Smithii (p-value = .04) in SBS patients than controls. Conclusions: The significantly different fecal microbiome in SBS patients compared with healthy controls could open new perspectives on the care of their intestinal functions