Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

A classification scheme for landfalling tropical cyclones based on precipitation variables derived from GIS and ground radar analysis

Landfalling tropical cyclones present a multitude of hazards that threaten life and property to coastal and inland communities. These hazards are most commonly categorized by the Saffir-Simpson Hurricane Potential Disaster Scale. Currently, there is not a system or scale that categorizes tropical cyclones by precipitation and flooding, which is the primary cause of fatalities and property damage from landfalling tropical cyclones. This research compiles ground based radar data (Nexrad Level-III) in the U.S. and analyzes tropical cyclone precipitation data in a GIS platform. Twenty-six landfalling tropical cyclones from 1995 to 2008 are included in this research where they were classified using Cluster Analysis. Precipitation and storm variables used in classification include: rain shield area, convective precipitation area, rain shield decay, and storm forward speed. Results indicate six distinct groups of tropical cyclones based on these variables. (Published By University of Alabama Libraries