Las conexiones entre el Derecho y la moral

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Cerebellar Atrophy in Congenital Fibrosis of the Extraocular Muscles Type 1

We described a family with a molecularly confirmed form of CFEOM1 and a late-onset cerebellar syndrome. Brain MRI showed vermis atrophy in two older family members, who also manifested gait impairment, whereas both neurological examination and neuroimaging findings were normal in a younger relative who harbored the same mutation

How Fast is Furious The Discourse of Fast Cinema in Question

Considered in its articulation with an idea of “slow” cinema, the label “fast cinema” suggests three characteristics: fast-paced action, hyperkinetic cinematic style, and irreflexive consumption. Not only does fast cinema suggest these three characteristics, however, it also suggests that they directly correspond to each other so that, in a “fast” film, fast-paced action would be seamlessly rendered through “fast” cinematic enunciation and this rendering would necessarily result in an escapist, ready-to-consume film product. It is more by this correspondence, I think, than by any of these elements on its own that a certain understanding of “fast” cinema is established. Against this understanding, through a variety of contrasting examples, the article argues that the impression of fastness and that of slowness are both the matter of a tension between different temporalities and a complex combination of heterogeneous film elements, and that the articulation of “fast” and “slow” cinema itself depends less on the formal characteristics of different kinds of film than on a disciplinary understanding of spectatorship, which pretends to derive from these formal characteristics different and unequal forms of film experience.Considered in its articulation with an idea of “slow” cinema, the label “fast cinema” suggests three characteristics: fast-paced action, hyperkinetic cinematic style, and irreflexive consumption. Not only does fast cinema suggest these three characteristics, however, it also suggests that they directly correspond to each other so that, in a “fast” film, fast-paced action would be seamlessly rendered through “fast” cinematic enunciation and this rendering would necessarily result in an escapist, ready-to-consume film product. It is more by this correspondence, I think, than by any of these elements on its own that a certain understanding of “fast” cinema is established. Against this understanding, through a variety of contrasting examples, the article argues that the impression of fastness and that of slowness are both the matter of a tension between different temporalities and a complex combination of heterogeneous film elements, and that the articulation of “fast” and “slow” cinema itself depends less on the formal characteristics of different kinds of film than on a disciplinary understanding of spectatorship, which pretends to derive from these formal characteristics different and unequal forms of film experience

The cinematographic community: Fernand Deligny’s ‘tentatives’ and radical film education

Fernand Deligny’s experiments with film in the context of social work and therapeutic communities since the 1950s are part of what Marlon Miguel calls ‘semi hidden histories’, whose study is broadening the landscape of film theory and film education. Located at the margins of institutional forms of teaching and care, the ‘tentatives’ organised by Deligny involved a participatory use of the camera, the idea of film and film-making as an egalitarian and heterotopian space, and rested on the formation of radically inclusive communities. This article focuses on the proximity Deligny saw between cinema and that ‘common body’, made of contingent events and impersonal gestures, which for him constituted the common ground of the human. Inspired by the principles of éducation nouvelle, by his life with non-speaking autistic children, and taking shape through a collaboration with Gilles Deleuze and Félix Guattari, Deligny’s work placed itself within an alternative vision of education, beyond the pedagogical model later criticised by Jacques Rancière, which understands it not as a series of techniques for the transmission of knowledge, but rather as a fundamental dimension of collective life

Diversity of greek meningococcal serogroup B isolates and estimated coverage of the 4CMenB meningococcal vaccine

International audienceBACKGROUND: Serogroup B meningococcal (MenB) isolates currently account for approximately 90% of invasive meningococcal disease (IMD) in Greece with ST-162 clonal complex predominating. The potential of a multicomponent meningococcal B vaccine (4CMenB) recently licensed in Europe was investigated in order to find whether the aforementioned vaccine will cover the MenB strains circulating in Greece. A panel of 148 serogroup B invasive meningococcal strains was characterized by multilocus sequence typing (MLST) and PorA subtyping. Vaccine components were typed by sequencing for factor H-binding protein (fHbp), Neisserial Heparin Binding Antigen (NHBA) and Neisseria adhesin A (NadA). Their expression was explored by Meningococcal Antigen Typing System (MATS). RESULTS: Global strain coverage predicted by MATS was 89.2% (95% CI 63.5%-98.6%) with 44.6%, 38.5% and 6.1% of strains covered by one, two and three vaccine antigens respectively. NHBA was the antigen responsible for the highest coverage (78.4%), followed by fHbp (52.7%), PorA (8.1%) and NadA (0.7%). The coverage of the major genotypes did not differ significantly. The most prevalent MLST genotype was the ST-162 clonal complex , accounting for 44.6% of the strains in the panel and with a predicted coverage of 86.4%, mainly due to NHBA and fHbp. CONCLUSIONS: 4CMenB has the potential to protect against a significant proportion of Greek invasive MenB strains

La violencia sin rostro y los comunes gestuales: la ética y la política de la destitución y el apoyo en Butler, Agamben y Federici

This article brings to bear different strands of critical theory on the issue of police violence and securitarian capitalism, with a focus on the current situation in France, discussing Judith Butler’s argument for nonviolence in The Force of Nonviolence in relation to Jacques Rancière’s distinction of politics and police, Giorgio Agamben’s ideas of gesture and act, and Silvia Federici’s understanding of primitive accumulation and reproductive commons. These authors, from their different perspectives, address how the questions of the distribution and the legitimation of violence involve forms of individuation that cut into a common dimension of relationality and interdepen- dency, systematically denying structural violence. On this basis, they understand the ethics and politics of nonviolence to be the matter of a common use of bodies: Butler, in the sense of an aggressive defence of those interrelational bonds that are formative of human subjects; Agamben, in the sense of a shift in our mode of thinking and doing from property and belonging to use and dwelling, as part of the destitution of the biopolitical and juridical capture of lives; Federici, as forms of mutual support organised in a struggle against the imposition of capitalist relations of production and reproduction. Moving from the question of the figuration of violence and the State’s semantic monopoly on its attribution to that of police violence and its centrality in the current paradigm of government, the article connects the various epistemologies of subjectivity in Butler, Agamben, and Federici to the critique of techniques of individuation and structural forms of vulnerabilisation that are characteristic of the police State, proposing an anarchist perspective on nonviolence as part of a larger defence of reproductive and gestural commons.Este artículo aporta diferentes líneas de teoría crítica sobre el tema de la violencia policial y el capitalismo securitario, con un enfoque en la situación actual en Francia, discutiendo el argumento de Judith Butler a favor de la noviolencia en The Force of Nonviolence (La fuerza de la noviolencia) en relación con la distinción de política y policía de Jacques Rancière, las ideas de gesto y acto de Giorgio Agamben, y la comprensión de Silvia Federici de la acumulación primitiva y los bienes comunes reproductivos. Estos autores, desde sus diferentes perspectivas, abordan cómo las cuestiones de la distribución y la legitimación de la violencia implican formas de individualización que se cruzan en una dimensión común de relacionalidad e interdependencia, negando sistemáticamente la violencia estructural. Sobre esta base, entienden la ética y la política de la noviolencia como materia de un uso común de los organismos: Butler, en el sentido de una defensa agresiva de aquellos lazos interrelacionales que son formativos de los sujetos humanos; Agamben, en el sentido de un cambio en nuestro modo de pensar y hacer desde la propiedad y la pertenencia hasta el uso y la vivienda, como parte de la destitución de la captura biopolítica y jurídica de las vidas; Federici, como formas de apoyo mutuo organizadas en una lucha contra la imposición de las relaciones capitalistas de producción y reproducción. Pasando de la cuestión de la figuración de la violencia y el monopolio semántico del Estado sobre su atribución a la violencia policial y su centralidad en el paradigma de gobierno actual, el artículo conecta las diversas epistemologías de la subjetividad en Butler, Agamben y Federici a la crítica de técnicas de individualización y formas estructurales de vulneración propias del Estado policial, y propone una perspectiva anarquista de la noviolencia como parte de una defensa más amplia de los bienes comunes reproductivos y gestuales

Effectiveness of Meningococcal B Vaccine against Endemic Hypervirulent Neisseria meningitidis W Strain, England

Serum samples from children immunized with a meningococcal serogroup B vaccine demonstrated potent serum bactericidal antibody activity against the hypervirulent Neisseria meningitidis serogroup W strain circulating in England. The recent introduction of this vaccine into the United Kingdom national immunization program should also help protect infants against this endemic strain

Synthesis of Soundfields through Irregular Loudspeaker Arrays Based on Convolutional Neural Networks

Most soundfield synthesis approaches deal with extensive and regular loudspeaker arrays, which are often not suitable for home audio systems, due to physical space constraints. In this article we propose a technique for soundfield synthesis through more easily deployable irregular loudspeaker arrays, i.e. where the spacing between loudspeakers is not constant, based on deep learning. The input are the driving signals obtained through a plane wave decomposition-based technique. While the considered driving signals are able to correctly reproduce the soundfield with a regular array, they show degraded performances when using irregular setups. Through a Convolutional Neural Network (CNN) we modify the driving signals in order to compensate the errors in the reproduction of the desired soundfield. Since no ground-truth driving signals are available for the compensated ones, we train the model by calculating the loss between the desired soundfield at a number of control points and the one obtained through the driving signals estimated by the network. Numerical results show better reproduction accuracy both with respect to the plane wave decomposition-based technique and the pressure-matching approach

Synthetic Training Set Generation using Text-To-Audio Models for Environmental Sound Classification

In recent years, text-to-audio models have revolutionized the field of automatic audio generation. This paper investigates their application in generating synthetic datasets for training data-driven models. Specifically, this study analyzes the performance of two environmental sound classification systems trained with data generated from text-to-audio models. We considered three scenarios: a) augmenting the training dataset with data generated by text-to-audio models; b) using a mixed training dataset combining real and synthetic text-driven generated data; and c) using a training dataset composed entirely of synthetic audio. In all cases, the performance of the classification models was tested on real data. Results indicate that text-to-audio models are effective for dataset augmentation, with consistent performance when replacing a subset of the recorded dataset. However, the performance of the audio recognition models drops when relying entirely on generated audio