MODELING U.S. BROILER SUPPLY RESPONSE: A STRUCTURAL TIME SERIES APPROACH

A structural time series model is used to estimate the supply response function for broiler production in the United States using quarterly data and a structural time series model. This model has the advantage of expressing trend and seasonal elements as stochastic components, allowing a dynamic interpretation of the results and improving the forecast capabilities of the model. The results of the estimation indicate the continued importance of feed cost to poultry production and of technology as expressed by the stochastic trend variable. However, seasonal influences appear to have become less important, since the seasonal component was not statistically significant.Livestock Production/Industries,

The Effect of Management Regime on Airborne Respirable Dust Concentrations in Two Different Types of Horse Stable Design

Airborne respirable dust (ARD) (<5 mm) in the stable environment is strongly implicated in equine asthma. Bedding, forage, ventilation rate, and stable management activities all contribute to ARD. This study investigated the relationship between ARD in the breathing zone (BZ) and the stable zone (SZ) in eight American barns (ABs) and eight stable complexes with individual stables under four different management regimes. Airborne respirable dust was measured in eight replicate stables per regime in ABs (n ¼ 32) and eight per regime in single stables (n ¼ 32). Regimes were as follows: (1) steamed hay and shavings; (2) dry hay and shavings; (3) haylage and straw; and (4) dry hay and straw. Samples were taken in quite periods between 3 PM and 4 PM hours. Airborne respirable dust levels were analyzed using Split-Plot analysis of variance and Wilcoxon matched-pairs test (Genstat 15) with P <.05 as significant. The lowest ARD (<360 RP/L air) was found for shavings and steamed hay in AB and single stables in both BZ and SZ. Straw and dry hay in ABs produced ARD of 6,250 (SZ), 5,079 RP/L air (BZ) which was greater (P < .05) than the 2,901 (SZ) and 942 (BZ) RP/L air in single stables. Straw and haylage produced more ARD across both zones in single stables compared with ABs. Shavings and dry hay ¼ more dust in the BZ than in the SZ, whereas straw and haylage ¼ higher ARD in the SZ versus the BZ across both stable designs. Using dry hay and/or straw cannot be recommended as a suitable management regime for stabled horses

Response of corn to nitrogen fertilization and plant population : 1967 tests

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Response of corn to nitrogen and variation in plant population : 1968 tests

Cover title."This report is a joint contribution of the Department of Agronomy and Agriculture Economics on research project 455, the Economics of Fertilizer Use in Missouri"--P. [2]

Response of corn to nitrogen fertilization and plant population : 1965 tests and five year summary

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Selection Of A Novel Aptamer Against Vitronectin Using Capillary Electrophoresis And Next Generation Sequencing

Breast cancer (BC) results in ≃40,000 deaths each year in the United States and even among survivors treatment of the disease may have devastating consequences, including increased risk for heart disease and cognitive impairment resulting from the toxic effects of chemotherapy. Aptamer-mediated drug delivery can contribute to improved treatment outcomes through the selective delivery of chemotherapy to BC cells, provided suitable cancer-specific antigens can be identified. We report here the use of capillary electrophoresis in conjunction with next generation sequencing to develop the first vitronectin (VN) binding aptamer (VBA-01; Kd 405 nmol/l, the first aptamer to vitronectin (VN; Kd = 405 nmol/l), a protein that plays an important role in wound healing and that is present at elevated levels in BC tissue and in the blood of BC patients relative to the corresponding nonmalignant tissues. We used VBA-01 to develop DVBA-01, a dimeric aptamer complex, and conjugated doxorubicin (Dox) to DVBA-01 (7:1 ratio) using pH-sensitive, covalent linkages. Dox conjugation enhanced the thermal stability of the complex (60.2 versus 46.5°C) and did not decrease affinity for the VN target. The resulting DVBA-01-Dox complex displayed increased cytotoxicity to MDA-MB-231 BC cells that were cultured on plasticware coated with VN (1.8 × 10⁻⁶mol/l) relative to uncoated plates (2.4 × 10⁻⁶ mol/l), or plates coated with the related protein fibronectin (2.1 × 10⁻⁶ mol/l). The VBA-01 aptamer was evaluated for binding to human BC tissue using immunohistochemistry and displayed tissue specific binding and apparent association with BC cells. In contrast, a monoclonal antibody that preferentially binds to multimeric VN primarily stained extracellular matrix and vessel walls of BC tissue. Our results indicate a strong potential for using VN-targeting aptamers to improve drug delivery to treat BC

Clients’ Perspectives of Meaningful Healthcare Relationships

The aim of this study was to increase understanding of how clients view meaningful relationships within the healthcare context and how clients respond to differences in approaches or expectations for a meaningful relationship

The Effect of Moxidectin Treatment on the Equine Hind Gut Microbiome, Metabonome and Feed Fermentation Kinetics in Horses with Very Low Parasite Burdens

Seventeen horses, mean 12 ± 3.5 years, kept at pasture, with haylage provided and no concentrates. Faecal Egg Counts were conducted September 2015‐March 2016, no eggs seen, no anthelmintic given. Sampling commenced March 2016, points were 0 (prior), 16, 48 and 168 hours post anthelmintic. Treatments were randomized, nine animals dosed orally with Moxidectin 18.92 mg/g at 0.4 mg/kg bw and eight controls. Three horses from each group were randomly assigned for fermentation kinetics. Sequencing of the 16S rRNA gene was conducted on extracted faecal bacterial DNA, bioinformatics using QIIME assigning operational taxonomic units (OTUs). LEfSe (Segata et al., 2011) was used to identify differentially abundant OTUs. Bacterial metabolic profiles were characterized by 1H NMR spectroscopy (Escalona et al., 2015), from urine, analysed by Principal Components Analysis. Fermentation of hay and oats, separately, were measured by in vitro gas production (Murray et al., 2006), data were analysed by repeated measures ANOVA

Electron scattering from molecules and molecular aggregates of biological relevance

In this Topical Review we survey the current state of the art in the study of low energy electron collisions with biologically relevant molecules and molecular clusters. We briefly describe the methods and techniques used in the investigation of these processes and summarise the results obtained so far for DNA constituents and their model compounds, amino acids, peptides and other biomolecules. The applications of the data obtained is briefly described as well as future required developments

Essential role of fats throughout the lifecycle : summary and recommendations

The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included.Robert A Gibson, Maria Makrides and Coral G B Colye