Uso de surfactante em modelo experimental de S?ndrome de Aspira??o de Mec?nio

Made available in DSpace on 2015-04-14T13:32:40Z (GMT). No. of bitstreams: 1 413832.pdf: 10977222 bytes, checksum: 57ede65b6619980480494bbe479e7a6a (MD5) Previous issue date: 2009-03-31Introdu??o: apesar de estar ocorrendo com menos freq??ncia, a s?ndrome de aspira??o de mec?nio ainda ? uma causa comum de insufici?ncia respirat?ria em rec?mnascidos a termo. Devido ? inativa??o do surfactante pelo mec?nio, o lavado broncoalveolar e a reposi??o de surfactante v?m sendo estudados nos ?ltimos anos. Objetivo: avaliar o efeito do lavado broncoalveolar com surfactante dilu?do e dose complementar de surfactante em modelo animal de s?ndrome de aspira??o de mec?nio. M?todos: foram utilizados 25 porcos a termo rec?m-nascidos, sendo ventilados com par?metros fixos durante todo o estudo. Ap?s a indu??o da aspira??o de mec?nio com 5ml/kg de mec?nio a 20%, os animais foram randomizados em 4 grupos: grupo I (n=9) - controle; grupo II (n=6) - lavado broncoalveolar com surfactante dilu?do (15ml/kg); grupo III (n=5) - lavado broncoalveolar com surfactante dilu?do (15ml/kg) seguido de dose complementar de surfactante (Curosurf? 100mg/kg); e grupo IV (n=5) - dose de surfactante (Curosurf? 100mg/kg) sem lavado broncoalveolar. As gasometrias arteriais foram coletadas 30 minutos e 3 horas ap?s a administra??o do mec?nio. Resultados: houve melhora significativa da PaO2 na gasometria coletada 30 minutos ap?s a indu??o da s?ndrome de aspira??o de mec?nio apenas no grupo III comparativamente ao grupo I [ PaO2 44+27 e 10+11, respectivamente (p=0,005)]. Ap?s 3 horas da interven??o, manteve-se uma melhora na oxigena??o apenas do grupo III comparativamente ao grupo controle [ PaO2 69+65 e 12+21, respectivamente (p=0,03)]. Conclus?o: a realiza??o de lavado broncoalveolar com surfactante dilu?do seguida de dose complementar de surfactante melhora a oxigena??o em curto prazo em modelo experimental de s?ndrome de aspira??o de mec?nio

Impactos da pandemia do coronavírus nos fluxos de atendimento do banco de leite humano de um hospital de Porto Alegre/RS

INTRODUTION: To understand the impacts of the pandemic on the donation of breastmilk through an evaluation of the service flow in the hospitals milk bank during the pandemic as well as to verify whether or not parameters such as those of milk donations and conducted tests have varied during the pandemic. BACKGROUND: A cross-sectional epidemiologic study was carried out through the comparison of the service flow and the volume of human milk collected by the milk bank between two periods (before and during the pandemic). The pre-pandemic period comprises the years between 2017 and 2019, whereas the pandemic period considered in this study stretches from March 1st 2020 to December 31st 2021. RESULTS: The number of group appointments during the pandemic suffered a considerable decrease, with an average of 0,2 appointments and a standard deviation (SD) of ± 0,9 in comparison to the pre-pandemic period, during which there was an average of 31,1 appointments with a standard deviation of ± 13,6 (p<0,001). In relation to the volume of milk that was collected, there was significant decrease during the pandemic, with an average of 28,9 liters collected per month and a standard deviation of (DP) ± 11,9 in comparison to the pre-pandemic period, during which there was an average of 59,8 liters per month and a standard deviation of ± 29,2 (p<0,001). CONCLUSION: During the pandemic, there was a substantial decrease of donors and therefore of the volume of milk which was donated to the milk bank