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Commercial Spent Nuclear Fuel Assembly Waste Volume and Weight Estimation for 63,000 MTU
The purpose of this calculation is to create a high-level estimation of the weights and volume of the commercial spent nuclear fuel (SNF) assemblies, at the time of repository receipt, that will comprise 63,000 metric tons of uranium (MTU) waste. The results of this calculation are for informational purposes only and are not intended to be used as input to design documents. This calculation was prepared in accordance with procedure AP-3.12Q REV 00 ICN 0, Calculations
Determining the shape of defects in non-absorbing inhomogeneous media from far-field measurements
International audienceWe consider non-absorbing inhomogeneous media represented by some refraction index. We have developed a method to reconstruct, from far-field measurements, the shape of the areas where the actual index differs from a reference index. Following the principle of the Factorization Method, we present a fast reconstruction algorithm relying on far field measurements and near field values, easily computed from the reference index. Our reconstruction result is illustrated by several numerical test cases
Resonance regimes of scattering by small bodies with impedance boundary conditions
The paper concerns scattering of plane waves by a bounded obstacle with
complex valued impedance boundary conditions. We study the spectrum of the
Neumann-to-Dirichlet operator for small wave numbers and long wave asymptotic
behavior of the solutions of the scattering problem. The study includes the
case when is an eigenvalue or a resonance. The transformation from the
impedance to the Dirichlet boundary condition as impedance grows is described.
A relation between poles and zeroes of the scattering matrix in the non-self
adjoint case is established. The results are applied to a problem of scattering
by an obstacle with a springy coating. The paper describes the dependence of
the impedance on the properties of the material, that is on forces due to the
deviation of the boundary of the obstacle from the equilibrium position
Convergence and Stability of the Inverse Scattering Series for Diffuse Waves
We analyze the inverse scattering series for diffuse waves in random media.
In previous work the inverse series was used to develop fast, direct image
reconstruction algorithms in optical tomography. Here we characterize the
convergence, stability and approximation error of the serie
Multivariate MR Biomarkers Better Predict Cognitive Dysfunction in Mouse Models of Alzheimers Disease
To understand multifactorial conditions such as Alzheimers disease (AD) we
need brain signatures that predict the impact of multiple pathologies and their
interactions. To help uncover the relationships between brain circuits and
cognitive markers we have used mouse models that represent, at least in part,
the complex interactions altered in AD. In particular, we aimed to understand
the relationship between vulnerable brain circuits and memory deficits measured
in the Morris water maze, and we tested several predictive modeling approaches.
We used in vivo manganese enhanced MRI voxel based analyses to reveal regional
differences in volume (morphometry), signal intensity (activity), and magnetic
susceptibility (iron deposition, demyelination). These regions included the
hippocampus, olfactory areas, entorhinal cortex and cerebellum. The image based
properties of these regions were used to predict spatial memory. We next used
eigenanatomy, which reduces dimensionality to produce sets of regions that
explain the variance in the data. For each imaging marker, eigenanatomy
revealed networks underpinning a range of cognitive functions including memory,
motor function, and associative learning. Finally, the integration of
multivariate markers in a supervised sparse canonical correlation approach
outperformed single predictor models and had significant correlates to spatial
memory. Among a priori selected regions, the fornix also provided good
predictors, raising the possibility of investigating how disease propagation
within brain networks leads to cognitive deterioration. Our results support
that modeling approaches integrating multivariate imaging markers provide
sensitive predictors of AD-like behaviors. Such strategies for mapping brain
circuits responsible for behaviors may help in the future predict disease
progression, or response to interventions.Comment: 23 pages, 3 Tables, 6 Figures; submitted for publicatio
On the Convergence of the Born Series in Optical Tomography with Diffuse Light
We provide a simple sufficient condition for convergence of Born series in
the forward problem of optical diffusion tomography. The condition does not
depend on the shape or spatial extent of the inhomogeneity but only on its
amplitude.Comment: 23 pages, 7 figures, submitted to Inverse Problem
Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke
The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 weeks post-stroke compared to control individuals. Cases were African-Americans with lacunar stroke (n = 30), and controls were age-matched African-Americans with no history of stroke or other major neurologic disease (n = 37). Blood was obtained \u3e 6 weeks post-stroke and was analyzed for inflammatory biomarkers. Freshly isolated peripheral blood mononuclear cells were stimulated with lipopolysaccharide (LPS) to assess immune responsiveness in a subset of cases (n = 5) and controls (n = 4). After adjustment for covariates, the pro-inflammatory biomarkers, soluble vascular cadherin adhesion molecule-1 (sVCAM-1) and thrombin anti-thrombin (TAT), were independently associated with lacunar stroke. Immune responsiveness to LPS challenge was abnormal in cases compared to controls. African-Americans with lacunar stroke had elevated blood levels of VCAM-1 and TAT and an abnormal response to acute immune challenge \u3e 6 weeks post-stroke, suggesting a chronically compromised systemic inflammatory response
Spectral properties of the Dirichlet-to-Neumann operator for exterior Helmholtz problem and its applications to scattering theory
We prove that the Dirichlet-to-Neumann operator (DtN) has no spectrum in the
lower half of the complex plane. We find several application of this fact in
scattering by obstacles with impedance boundary conditions. In particular, we
find an upper bound for the gradient of the scattering amplitude and for the
total cross section. We justify numerical approximations by providing bounds on
difference between theoretical and approximated solutions without using any a
priory unknown constants
Fourier Method for Approximating Eigenvalues of Indefinite Stekloff Operator
We introduce an efficient method for computing the Stekloff eigenvalues
associated with the Helmholtz equation. In general, this eigenvalue problem
requires solving the Helmholtz equation with Dirichlet and/or Neumann boundary
condition repeatedly. We propose solving the related constant coefficient
Helmholtz equation with Fast Fourier Transform (FFT) based on carefully
designed extensions and restrictions of the equation. The proposed Fourier
method, combined with proper eigensolver, results in an efficient and clear
approach for computing the Stekloff eigenvalues.Comment: 12 pages, 4 figure
Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders
Vogt-Koyanagi-Harada syndrome (VKH) and vitiligo are autoimmune diseases that target melanocytes. VKH affects several organs such as the skin, hair follicle, eyes, ears, and meninges, whereas vitiligo is often limited to the skin and mucosa. Many studies have identified immune genes, pathways and cells that drive the pathogeneses of VKH and vitiligo, including interleukins, chemokines, cytotoxic T-cells, and other leukocytes. Here, we present case studies of 2 canines with VKH and 1 with vitiligo, which occurred spontaneously in client-owned companion dogs. We performed comparative transcriptomics and immunohistochemistry studies on lesional skin biopsies from these cases in order to determine if the immunopathogenesis of autoimmune responses against melanocytes are conserved. In dogs, we found enrichment of T cell gene signatures, with upregulation of IFNG, TNF, PRF1, IL15, CTSW, CXCL10, and CCL5 in both VKH and vitiligo in dogs compared to healthy controls. Similar findings were reported in humans, suggesting that these genes play a role in the pathogenesis of spontaneous VKH and vitiligo. T cell-associated genes, including FOXP3 and TBX21, were enriched, while IGFBP5, FOXO1, and PECAM1 were decreased compared to healthy controls. Further, we identified TGFB3, SFRP2, and CXCL7 as additional potential drivers of autoimmune pigmentary disorders. Future studies exploring the immunopathogenesis of spontaneous autoimmunity will expand our understanding of these disorders, and will be useful in developing targeted therapies, repurposing drugs for veterinary and human medicine, and predicting disease prognosis and treatment response
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