2,567 research outputs found
The QT interval in lightning injury with implications for the cessation of metabolism hypothesis
An hypothesis is presented to provide an alternative to the Cessation of Metabolism hypothesis often invoked in lightning injury. Cessation of Metabolism has been proposed to explain the observation of good recovery after a prolonged period in cardiac arrest in some lightning injured patients. Reevaluation of EEGs from lightning injured patients show a high incidence of QT prolongation. Reexamination of the cases used to support Cessation of Metabolism also reveals little evidence to justify the hypothesis. The finding of QT prolongation coupled with the hyperadrenergic state said to exist in lightning injury, may promote a state of episodic induction of and recovery from Torsade de Pointes Ventricular Tachycardia (VT). Histological examination of the myocardium supports the new hypothesis. This the first concerted description of lightning injury as one of the general causes of QT prolongation. It appears to occur frequently after lightning injury, is a prerequisite of and predisposes to episodes of Torsade de Pointes VT. These electrocardiographic abnormalities explain Cessation of Metabolism and recognition may change management and lead to greater survival
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Direct iminization of PEEK
Semi-crystalline poly(ether ketone)s are important high-temperature engineering thermoplastics, but are difficult to characterize at the molecular level because of their insolubility in conventional organic solvents. Here we report that polymers of this type, including PEEK, react cleanly at high temperatures with low-volatility aralkyl amines to afford stable, noncrystalline poly(ether-imine)s, which are readily soluble in solvents such as chloroform, THF and DMF and so characterizable by conventional size-exclusion chromatography
Francisella infections in farmed and wild aquatic organisms
Over the last 10 years or so, infections caused by bacteria belonging to a particular branch of the genus Francisella have become increasingly recognised in farmed fish and molluscs worldwide. While the increasing incidence of diagnoses may in part be due to the development and widespread availability of molecular detection techniques, the domestication of new organisms has undoubtedly instigated emergence of clinical disease in some species. Francisellosis in fish develops in a similar fashion independent of host species and is commonly characterised by the presence of multi-organ granuloma and high morbidity, with varying associated mortality levels. A number of fish species are affected including Atlantic cod, Gadus morhua; tilapia, Oreochromis sp.; Atlantic salmon, Salmo salar; hybrid striped bass, Morone chrysops × M. saxatilis and three-lined grunt, Parapristipoma trilinineatum. The disease is highly infectious and often prevalent in affected stocks. Most, if not all strains isolated from teleost fish belong to either F. noatunensis subsp. orientalis in warm water fish species or Francisella noatunensis subsp. noatunensis in coldwater fish species. The disease is quite readily diagnosed following histological examination and identification of the aetiological bacterium by culture on cysteine rich media or PCR. The available evidence may indicate a degree of host specificity for the various Francisella strains, although this area requires further study. No effective vaccine is currently available. Investigation of the virulence mechanisms and host response shows similarity to those known from Francisella tularensis infection in mammals. However, no evidence exists for zoonotic potential amongst the fish pathogenic Francisella
B-meson decay constants: a more complete picture from full lattice QCD
We extend the picture of -meson decay constants obtained in lattice QCD
beyond those of the , and to give the first full lattice QCD
results for the , and . We use improved NonRelativistic QCD
for the valence quark and the Highly Improved Staggered Quark (HISQ) action
for the lighter quarks on gluon field configurations that include the effect of
, and quarks in the sea with quark masses going down to
physical values. For the ratio of vector to pseudoscalar decay constants, we
find = 0.941(26), = 0.953(23) (both
less than 1.0) and = 0.988(27). Taking correlated
uncertainties into account we see clear indications that the ratio increases as
the mass of the lighter quark increases. We compare our results to those using
the HISQ formalism for all quarks and find good agreement both on decay
constant values when the heaviest quark is a and on the dependence on the
mass of the heaviest quark in the region of the . Finally, we give an
overview plot of decay constants for gold-plated mesons, the most complete
picture of these hadronic parameters to date.Comment: 20 pages, 9 figures. Minor updates to the discussion in several
places and some additional reference
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Conformational modulation of sequence recognition in synthetic macromolecules
The different triplet sequences in high molecular weight aromatic copolyimides comprising pyromellitimide units ("I") flanked by either ether-ketone ("K") or ether-sulfone residues ("S") show different binding strengths for pyrene-based tweezer-molecules. Such molecules bind primarily to the diimide unit through complementary π-π-stacking and hydrogen bonding. However, as shown by the magnitudes of 1H NMR complexation shifts and tweezer-polymer binding constants, the triplet "SIS" binds tweezer-molecules more strongly than "KIS" which in turn bind such molecules more strongly than "KIK". Computational models for tweezer-polymer binding, together with single-crystal X-ray analyses of tweezer-complexes with macrocyclic ether-imides, reveal that the variations in binding strength between the different triplet sequences arise from the different conformational preferences of aromatic rings at diarylketone and diarylsulfone linkages. These preferences determine whether or not chain-folding and secondary π−π-stacking occurs between the arms of the tweezermolecule and the 4,4'-biphenylene units which flank the central diimide residue
Υ and Υ′ leptonic widths, abμ, and mb from full lattice QCD
We determine the decay rate to leptons of the ground-state ϒ meson and its first radial excitation in lattice
QCD for the first time. We use radiatively improved nonrelativistic QCD for the b quarks and include u, d,
s and c quarks in the sea with u=d masses down to their physical values. We find Γðϒ → eþe−Þ ¼
1.19ð11Þ keV and Γðϒ0 → eþe−Þ ¼ 0.69ð9Þ keV, both in good agreement with experimental results. The
decay constants we obtain are included in a summary plot of meson decay constants from lattice QCD
given in the Conclusions. We also test time moments of the vector current-current correlator against values
determined from the b-quark contribution to σðeþe− → hadronsÞ and calculate the b-quark piece of the
hadronic vacuum polarization contribution to the anomalous magnetic moment of the muon,
ab
μ ¼ 0.271ð37Þ × 10−10. Finally we determine the b-quark mass, obtaining in the MS scheme, ¯
m¯ bðm¯ b; nf ¼ 5Þ ¼ 4.196ð23Þ GeV, the most accurate result from lattice QCD to date
Ion-channel-like behavior in lipid bilayer membranes at the melting transition
It is well known that at the gel-liquid phase transition temperature a lipid
bilayer membrane exhibits an increased ion permeability. We analyze the
quantized currents in which the increased permeability presents itself. The
open time histogram shows a "-3/2" power law which implies an open-closed
transition rate that decreases like as time evolves. We
propose a "pore freezing" model to explain the observations. We discuss how
this model also leads to the noise that is commonly observed in
currents across biological and artificial membranes.Comment: 5 pages, 4 figure
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Synthesis, x-ray structure and anion binding properties of a cryptand-like hybrid calixpyrrole
The novel cryptand in/out-3, containing two tripyrrolemethane units briged by three 1,3- diisopropylidenbenzene arms was readily synthesized by a convergent three-step synthesis. It binds fluoride by inclusion with excellent selectivity with respect to a number of other tested anions. The structure of the free receptor and that of its fluoride complex were investigated in solution by NMR spectroscopy. The solid state X-ray structure of the free cryptand 3 was also determined
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