The Influence of Native-Language Phonology on Lexical Access: Exemplar-Based Versus Abstract Lexical Entries

International audienc

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics

Lexical Acces in Speech Production: The Bilingüal Case

En este artículo se revisan modelos de acceso léxico en producción de lenguaje en hablantes bilingües. Nos centramos en dos aspectos fundamentales del acceso léxico: a) cómo se alcanza la selección léxica , y b) si el acceso léxico implica estadios de procesamiento discretos o en cascada. Comenzamos considerando supuestos importantes sobre el funcionamiento del acceso léxico en monolingües, para después discutirlos en el contexto de los hablantes bilingües. Se describen los modelos teóricos y la evidencia empírica reciente acorde a estos supuestos

Getting to the source : a questionnaire on the learning and use of arithmetical operations

Some current models of mathematical cognition (Dehaene, 1992; Campbell & Clark, 1992) make strong claims about the code in which arithmetical operations are solved, basing themselves on how these operations were originally acquired or are most frequently employed. However, data on acquisition and use are often derived from anecdotic reports and no systematic figures have ever been collected. In this study a questionnaire was devised to investigate how participants learned multiplication tables, as well as the code in which one-digit and multi-digit operations are usually solved. The questionnaire was administered to two groups of university students, one Spanish (Study 1) and the other Belgian (Study 2). The results show that multiplication tables are mainly learnt by oral rehearsal, but adults solve multiplications more frequently by visualizing Arabic digits. This is also their preferred code for calculating additions, subtractions, and divisions. The preference for the Arabic code increases when subjects have to solve multidigit operations. (Contains 1 figure, 5 tables and 7 footnotes.

Cognitiva

Resúmen basado en el del autor. Resúmen en castellano y en inglésSe investigan el desarrollo temporal de la codificación fonológica en la producción del lenguaje mediante cinco experimentos. En el Experimento 1 se utilizan una tarea de preparación de la respuesta y observamos que la producción de las palabras bisílabas podía ser facilitada tanto si los hablantes conocían con anterioridad la primera como la segunda sílaba. Los resultados del Experimento 2 se confirma que este efecto estaba sucediendo durante la producción. En los Experimentos 3 y 4, los participantes realizaron una tarea de detección de fonemas sobre palabras elicitadas a partir de la presentación de un dibujo. Los resultados de ambos experimentos mostraron que el fonema inicial de las palabras se detectaba más rápidamente que el resto de posiciones consonánticas, las cuales no diferieron entre sí. El Experimento 5 se utilizó como un control en que los participantes realizaron la tarea estándar de detección de fonemas sobre palabras presentadas auditativamente y que correspondían a los nombres de los dibujos empleados en el experimento 4. Como resultado, se obtuvo un aumento del tiempo de resupesta a medida que la posición del fonema dentro de la palabra se desplazaba hacia la derecha. Se considera conjuntamente, estos resultados ponen en entredicho el presupuesto de que la codificación fonológica es un proceso estrictamente serial.MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

Abnormal error monitoring in math-anxious individuals: evidence from error-related brain potentials.

This study used event-related brain potentials to investigate whether math anxiety is related to abnormal error monitoring processing. Seventeen high math-anxious (HMA) and seventeen low math-anxious (LMA) individuals were presented with a numerical and a classical Stroop task. Groups did not differ in terms of trait or state anxiety. We found enhanced error-related negativity (ERN) in the HMA group when subjects committed an error on the numerical Stroop task, but not on the classical Stroop task. Groups did not differ in terms of the correct-related negativity component (CRN), the error positivity component (Pe), classical behavioral measures or post-error measures. The amplitude of the ERN was negatively related to participants' math anxiety scores, showing a more negative amplitude as the score increased. Moreover, using standardized low resolution electromagnetic tomography (sLORETA) we found greater activation of the insula in errors on a numerical task as compared to errors in a non-numerical task only for the HMA group. The results were interpreted according to the motivational significance theory of the ERN

COVID-19 in hospitalized HIV-positive and HIV-negative patients : A matched study

CatedresObjectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization