157 research outputs found
Coping Strategies Used by Female Victims of the Colombian Armed Conflict: The Women in the Colombian Conflict (MUCOCO) Program
The effects of armed conflict on women in post-conflict situations are an area of analysis for social disciplines. This study
will analyze the situation in Colombia, currently involved in a peace restoration process. The aim is to verify the efficacy of a
coping and emotion regulation program analyzing victimization as well as the coping strategies employed in response to these
violent acts. The program focuses on 62 women contacted through the Ruta PacÃfica de las Mujeres, a nongovernmental
organization. The program had a positive effect on women, reporting lower levels of posttraumatic stress, more functional
coping strategies, and less use of dysfunctional strategies. All emotional cognitive and social indicators improved. Women
felt emotionally better, perceiving greater social support and more trust in institutions. Survivors had more self-confidence
to achieve their goals and solve their problems. The implications in a context of peace reconstruction and search for social
cohesion are discussed.project (Proyectos CUD 2017) funded by the Oficina de Cooperación al Desarrollo (Development Cooperation Office) of the Universidad del PaÃs Vasco/Euskal Herriko Unibertsitatea (University of the Basque Country, Spain) and the University of Burgos funding for the research group SIQoL (Y133GI)
Transient elastography for predicting esophageal/gastric varices in children with biliary atresia
Obstructive Sleep Apnea Is Associated with Liver Damage and Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease
We assessed whether obstructive sleep apnea (OSA) and nocturnal hypoxemia are associated with severity of liver fibrosis and carotid atherosclerosis in patients with biopsy-proven NAFLD and low prevalence of morbid obesity. Secondary aim was to explore the association of OSA and hypoxemia with NASH and severity of liver pathological changes
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs
Backgrounds & Aims
Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening.
Methods
We combined new and existing genotype data for 10,516 cases and 20,772 controls from 5 European and 2 East Asian cohorts.
Results
We identified 56 genome-wide significant loci (20 novel) including 46 in European, 13 in Asian, and 41 in combined cohorts; and a 57th genome-wide significant locus (also novel) in conditional analysis of the European cohorts. Candidate genes at newly identified loci include FCRL3, INAVA, PRDM1, IRF7, CCR6, CD226, and IL12RB1, which each play key roles in immunity. Pathway analysis reiterated the likely importance of pattern recognition receptor and TNF signalling, JAK-STAT signalling, and differentiation of T helper (TH)1 and TH17 cells in the pathogenesis of this disease. Drug efficacy screening identified several medications predicted to be therapeutic in PBC, some of which are well-established in the treatment of other autoimmune disorders.
Conclusions
This study has identified additional risk loci for PBC, provided a hierarchy of agents that could be trialled in this condition, and emphasised the value of genetic and genomic approaches to drug discovery in complex disorders.
Lay summary
Primary biliary cholangitis (PBC) is a chronic liver disease that eventually leads to cirrhosis. In this study, we analysed genetic information from 10,516 people with PBC and 20,772 healthy individuals recruited in Canada, China, Italy, Japan, the UK, or the USA. We identified several genetic regions associated with PBC. Each of these regions contains several genes. For each region, we used diverse sources of evidence to help us choose the gene most likely to be involved in causing PBC. We used these ‘candidate genes’ to help us identify medications that are currently used for treatment of other conditions, which might also be useful for treatment of PBC
Absence of hepatitis B virus DNA in patients with hepatitis C and non-A-E hepatitis in the State of São Paulo, Brazil
Angiopoietin-like protein as a novel marker for liver fibrosis in chronic hepatitis B patients with normal to minimally raised ALT
Evaluation of the nonalcoholic fat liver disease fibrosis score for patients undergoing bariatric surgery
Using the present to interpret the past: the role of ethnographic studies in Andean archaeology
Within Andean research it is common to use ethnographic analogies to aid the interpretation of archaeological remains, and ethnographers and archaeologists have developed shared research in technology, material culture and material practice. Although most of this research does not follow the detailed recording methods of spatial patterning envisioned in earlier formulations of ethnoarchaeology, it has had a profound effect on how archaeology in the region has been interpreted. This paper uses examples from the study of pottery production to address earlier debates about the use of ethnographic analogy, discusses the dangers of imposing an idealised or uniform vision of traditional Andean societies onto earlier periods (‘Lo Andino’) but stresses the benefits of combining ethnographic and archaeological research to explore continuities and changes in cultural practice and regional variations
The Precarious State of the Liver After a Fontan Operation: Summary of a Multidisciplinary Symposium
Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study
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