The Westerville Naturals Baseball Team & Otterbein Health And Sport Sciences, Student Project

We had the privilege to give back to our community in the form of manual labor. The Westerville Naturals baseball team needed a hand moving gravel in order to store a shed behind their field. The team provided a gator to transport the gravel from the parking lot to the field. The objective was to scoop shovels full of gravel into the back of the gator. We took multiple trips to load the five tons of gravel and transport it to the new location. Once moved, the sheds needed a facelift so it was decided to paint the sheds. We were able to get in-touch with the coach and schedule a date and time that worked best with all of our schedules. We have also organized the opportunity for the Westerville Naturals’ players take the field with the Otterbein baseball players at a home game, while the national anthem was played. We are hoping this will be the start of a tradition/legacy that the kids look forward too for many years to come. The practice and game field conditions for the youth team will be much more efficient in setting up and tearing down each day. Now that equipment storage is in place, with a more sturdy foundation than before, the team has a tangible reminder about the work that are students were willing to do for them, in order to show support of their team. The entire project has proven to be successful, the only difficult thing being the scheduling. We had to make sure it worked with their team as well as our schedules before we could get started. In the future we would recommend having a few gators to transport the gravel, as it seemed we were standing around waiting for it to get back after being dumped. We would have also liked to have had a larger budget to provide the youth athletes with a piece of memorabilia to remind them of their experience with the Otterbein Baseball Team

Light thresholds for seagrasses of the GBRWHA: a synthesis and guiding document

[Extract]. Key Findings. This synthesis contains light thresholds for seagrass species in the Great Barrier Reef World Heritage Area (GBRWHA). The thresholds can be applied to ensure protection of seagrasses from activities that impact water quality and the light environment over the short-term, such as coastal and port developments. Thresholds for long-term maintenance of seagrasses are also proposed. •The synthesis provides clear and consistent guidance on light thresholds to apply in managing potential water quality impacts to seagrass. •All available information on biological light thresholds was tabulated and conservative management thresholds were identified to ensure seagrass protection. •Acute management thresholds are suited to compliance guidelines for managing short-term impacts and these and are the focus of this synthesis. Long-term thresholds are suited to the setting of water quality guidelines for catchment management. •The synthesis identified key areas where further information is required, including: ◦species for which almost no information on light thresholds exists; ◦location and population-specific thresholds particularly for the most at-risk species; ◦definitions of desired state to underpin the development of long-term light guidelines to meet them; ◦the effect of spectral quality on light thresholds; and, consideration of cumulative impacts (temperature, nutrients, sedimentary conditions) on acute and long-term light thresholds. •Light management thresholds for acute impacts are presented for twelve species. Colonising species are the most sensitive to light reduction (i.e. lowest thresholds) and have the shortest time to impact while larger, persistent species have higher light thresholds and a longer time to impact. •The recommended acute management thresholds are ready for application, as the conservative approach (higher light threshold, shortest time to impact) for species with low confidence should ensure protection to seagrass meadows at risk from acute light stress

Functions of Phenylalanine Residues within the β-Barrel Stem of the Anthrax Toxin Pore

Background: A key step of anthrax toxin action involves the formation of a protein-translocating pore within the endosomal membrane by the Protective Antigen (PA) moiety. Formation of this transmembrane pore by PA involves interaction of the seven 2b2–2b3 loops of the heptameric precursor to generate a 14-strand transmembrane b barrel. Methodology/Principal Findings: We examined the effects on pore formation, protein translocation, and cytotoxicity, of mutating two phenylalanines, F313 and F314, that lie at the tip the b barrel, and a third one, F324, that lies part way up the barrel. Conclusions/Significance: Our results show that the function of these phenylalanine residues is to mediate membrane insertion and formation of stable transmembrane channels. Unlike F427, a key luminal residue in the cap of the pore, F313, F314, and F324 do not directly affect protein translocation through the pore. Our findings add to our knowledge of structure-function relationships of a key virulence factor of the anthrax bacillus

TGF-β isoforms fail to modulate inositol phosphates and cAMP in normal and tumour-derived human oral keratinocytes

AbstractThis study examined inositol phosphate and cAMP regulation by TGF-β1, -β2 and -β3 in normal and tumour-derived human oral keratinocytes. Previous findings indicated that the cell lines expressed TGF-β cell surface receptors and had a range of response to exogenous TGF-β1, -β2 and -β3 from being refractory to the ligand to marked inhibition. Basal levels of inositol phosphates broadly reflected the differentiation status of the cells as demonstrated by involucrin expression, but did not correlate with responsiveness to TGF-β1, as measured previously by thymidine incorporation. Treatment of cells with bradykinin or serum caused up-regulation of inositol phosphate levels; by contrast, TGF-β1, -β2 and -β3 failed to modulate inositol phosphates. In two tumour-derived cell lines, the TGF-β isoforms had no effect on cAMP levels, despite a significant increase in cAMP using a potent agonist of adenylate cyclase (forskolin). Furthermore, the cAMP analogue, dibutyryl cAMP, failed to mimic the inhibitory or refractory responses of TGF-β in these cell lines. The results demonstrate that in normal and tumour-derived human oral keratinocytes, TGF-β signal transduction is not mediated by inositol phosphates or cAMP

WALLABY Early Science - I. The NGC 7162 Galaxy Group

We present Widefield ASKAP L-band Legacy All-sky Blind Survey (WALLABY) early science results from the Australian Square Kilometre Array Pathfinder (ASKAP) observations of the NGC 7162 galaxy group. We use archival HIPASS and Australia Telescope Compact Array (ATCA) observations of this group to validate the new ASKAP data and the data reduction pipeline ASKAPsoft. We detect six galaxies in the neutral hydrogen (HI) 21-cm line, expanding the NGC 7162 group membership from four to seven galaxies. Two of the new detections are also the first HI detections of the dwarf galaxies, AM 2159-434 and GALEXASC J220338.65-431128.7, for which we have measured velocities of $cz=2558$ and $cz=2727$ km s$^{-1}$, respectively. We confirm that there is extended HI emission around NGC 7162 possibly due to past interactions in the group as indicated by the $40^{\circ}$ offset between the kinematic and morphological major axes for NGC 7162A, and its HI richness. Taking advantage of the increased resolution (factor of $\sim1.5$) of the ASKAP data over archival ATCA observations, we fit a tilted ring model and use envelope tracing to determine the galaxies' rotation curves. Using these we estimate the dynamical masses and find, as expected, high dark matter fractions of $f_{\mathrm{DM}}\sim0.81-0.95$ for all group members. The ASKAP data are publicly available.Comment: 20 pages, 11 figures, accepted for publication in MNRA

SPECULOOS exoplanet search and its prototype on TRAPPIST

One of the most significant goals of modern science is establishing whether life exists around other suns. The most direct path towards its achievement is the detection and atmospheric characterization of terrestrial exoplanets with potentially habitable surface conditions. The nearest ultracool dwarfs (UCDs), i.e. very-low-mass stars and brown dwarfs with effective temperatures lower than 2700 K, represent a unique opportunity to reach this goal within the next decade. The potential of the transit method for detecting potentially habitable Earth-sized planets around these objects is drastically increased compared to Earth-Sun analogs. Furthermore, only a terrestrial planet transiting a nearby UCD would be amenable for a thorough atmospheric characterization, including the search for possible biosignatures, with near-future facilities such as the James Webb Space Telescope. In this chapter, we first describe the physical properties of UCDs as well as the unique potential they offer for the detection of potentially habitable Earth-sized planets suitable for atmospheric characterization. Then, we present the SPECULOOS ground-based transit survey, that will search for Earth-sized planets transiting the nearest UCDs, as well as its prototype survey on the TRAPPIST telescopes. We conclude by discussing the prospects offered by the recent detection by this prototype survey of a system of seven temperate Earth-sized planets transiting a nearby UCD, TRAPPIST-1.Comment: Submitted as a chapter in the "Handbook of Exoplanets" (editors: H. Deeg & J.A. Belmonte; Section Editor: N. Narita). 16 pages, 4 figure

International Coercion, Emulation and Policy Diffusion: Market-Oriented Infrastructure Reforms, 1977-1999

Why do some countries adopt market-oriented reforms such as deregulation, privatization and liberalization of competition in their infrastructure industries while others do not? Why did the pace of adoption accelerate in the 1990s? Building on neo-institutional theory in sociology, we argue that the domestic adoption of market-oriented reforms is strongly influenced by international pressures of coercion and emulation. We find robust support for these arguments with an event-history analysis of the determinants of reform in the telecommunications and electricity sectors of as many as 205 countries and territories between 1977 and 1999. Our results also suggest that the coercive effect of multilateral lending from the IMF, the World Bank or Regional Development Banks is increasing over time, a finding that is consistent with anecdotal evidence that multilateral organizations have broadened the scope of the “conditionality” terms specifying market-oriented reforms imposed on borrowing countries. We discuss the possibility that, by pressuring countries into policy reform, cross-national coercion and emulation may not produce ideal outcomes.http://deepblue.lib.umich.edu/bitstream/2027.42/40099/3/wp713.pd