Cognition simulation and learning

The purpose of this paper is to describe new computer software that has been specifically developed to aid experiential learning in groups and with individuals. The software is designed to conduct a pseudosimula- tion involving ramifications and interaction of qualitative ideas, beliefs, attitudes, and values. It has been developed over the past four years through a continual interaction between the state of theory and software, and has been used with a variety of decision-making groups

Negotiation in strategy making teams : group support systems and the process of cognitive change

This paper reports on the use of a Group Support System (GSS) to explore at a micro level some of the processes manifested when a group is negotiating strategy-processes of social and psychological negotiation. It is based on data from a series of interventions with senior management teams of three operating companies comprising a multi-national organization, and with a joint meeting subsequently involving all of the previous participants. The meetings were concerned with negotiating a new strategy for the global organization. The research involved the analysis of detailed time series data logs that exist as a result of using a GSS that is a reflection of cognitive theory

Contrasting GDSS\u27s and GSS\u27s in the context of strategic change-implications for facilitation

The focus of this paper is on a comparison made between two series of computer supported strategy workshops. Each of the series of five one-day workshops was designed within the context of a project aimed at planning and implementing major strategic change within the organization and the project reported involved over fifty senior managers during a two year period. The subjects of the research had to deal with the reality of an organisational history, and, even more importantly, the knowledge that their contributions to the meetings would influence their future as a managerial group. The project enabled a number of exceptional opportunities to be tapped including i) a researcher as observer throughout the process, and ii) videotaping of each one day meeting. The first series of workshops was designed to generate and structure the strategic issues and context that were to be worked upon during the second series of workshops. Thus the first workshops used a group support system designed toprovide high levels of participation in raising strategic issues, and the second series, a group decision support system designed to enable decisions to be made and implementation plans to be created. These design objectives closely correspond to the tasks set out by McGrath (1984) where a GSS was defined as a support system to primarily aid creativity/idea generating tasks and a GDSS was to support planning/evaluation tasks. The workshops were each embedded within the Strategic Options Development and Analysis methodology (SODA) (Eden and Ackermann, 1992) and, involved a number of different support technologies. In these workshops the usual facilitated procedure was used in tandem with a multiple workstation system which allowed participants to interact with the modelling process, and with a number of manual techniques which were designed to interface with the approach. Thus manual group support (MAGS) was used alongside, and interacting with, both facilitator driven single user group support (SUGS) and multi-user group support (MUGS). To achieve this interweaving of modes the software COPE was used directly in both the SUGS and MUGS modes of support and the underlying concepts used during the MAGS mode mirrors the COPE software. The difference between the two series of workshops comprised i) the purposes behind the usage of each mode of working, and ii) the combinations adopted, i.e. the choice of using particular modes in a particular order which both have implications for facilitation. As a result of the comparison a set of implications which differentiate the role of a facilitator using group support systems (GSS) to the use of group decision support systems (GDSS) has been produced. The implications may be taken firstly as a contribution to the future design and facilitation of each type of meeting, and secondly to the effective design of the each of the systems (GSS and GDSS). The paper begins by considering some of the issues around the research method adopted, provides details of both of the workshop series, lists the characteristics which emerged as a result of the workshops and have implications for facilitation, and then briefly touches on the conclusions

Communities of Practice in Landscapes of Practice

The original formulation of communities of practice primarily focused on describing how learning, meaning, and identity within a community can translate into a sustained practice. Wenger-Trayner et al. elaborated the concept of landscapes of practice to describe how different communities of practice may interact, and belong to broader landscapes of practice, rather than rely exclusively on their own local situated practices. In this conceptual article, we apply the perspective of landscapes of practice to organizations. The first part of our argument is descriptive, and is aimed at developing a model of landscapes of practice in organizations. With regard to this model, we propose that practices can be seen as multilevel, including local situated practices, generic practices, and cultural fields. This, in turn, helps to clarify and organize a number of central concepts within the practice literature. The second part of our argument is prescriptive, as we suggest that landscapes of practice call for triple-legitimization of situated learning, meaning that legitimization is not only needed at the level of community and organization, but also by attending to the dynamically changing epistemic texture of the landscapes

Exploring GSS negotiation – the use of a GSS log

Group Decision Support Systems (GSS) have been used extensively to support groups in working together in organizations. This paper focuses on the particular type of GSS, called Group Explorer, which during the course of facilitated sessions generates data logs in the form of Excel spreadsheets. Data logs can be of high interest to researchers and GSS facilitators because they may possibly contain rich and valuable data such as about the detailed time of entry and the authorship of all contributions, or the results of voting activities conducted by participants. However, data logs may at first look complicated and difficult to read and follow. Thus the purpose of this paper is to provide a number of instructions and explanations for anyone interested in making good use of data logs, and to popularize similar analysis as a good opportunity to bet-ter understand the outcomes of GSS sessions

Knowledge Acquisition Using Group Support Systems

This paper reports on a project in which a group support system (GSS) equipped with a causal mapping facility was used to acquire knowledge from experts in seven European cities in order to understand the systemicity of risks which cities may face. The practical constraints demanded that participants’ experience and wisdom about the city risk environment was collected in a short period of time: three 1-day workshops. The acquisition of knowledge posed a number of important epistemological challenges which are explored in our discussion. The GSS was faced with the need to (1) facilitate sharing of knowledge with others, (2) manage the complexity of expert knowledge, (3) acknowledge the time demands on experts, (4) manage and merge multiple perspectives, and (5) acknowledge the subjectivity of knowledge in this domain. By discussing how the GSS process attended directly to these epistemological issues and to methodological considerations that linked to these issues, the paper contributes to a better understanding of the application of GSS for knowledge acquisition, particularly in comparison with other possible methods

Behavioral considerations in group support

This chapter highlights a series of inter-related issues that significantly affect the success and failure of group support for decision and negotiation. The issues are derived from the GDN experience of the author, accumulated over 40 years and hundreds GDN interventions. While they refer to some of the well-established literature on the topic, they are not based on formal empirical analysis. The items in the lists all raise issues that involve behavioral considerations. In particular it will be suggested that, notwithstanding a recent focus on microanalysis in GDN, these topics are still worthy of greater research and debate within the GDN research community

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase

l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism. The mechanisms of therapeutic failure with l-asparaginase remain speculative. Here, we now report that 2 lysosomal cysteine proteases present in lymphoblasts are able to degrade l-asparaginase. Cathepsin B (CTSB), which is produced constitutively by normal and leukemic cells, degraded asparaginase produced by Escherichia coli (ASNase) and Erwinia chrysanthemi. Asparaginyl endopeptidase (AEP), which is overexpressed predominantly in high-risk subsets of ALL, specifically degraded ASNase. AEP thereby destroys ASNase activity and may also potentiate antigen processing, leading to allergic reactions. Using AEP-mediated cleavage sequences, we modeled the effects of the protease on ASNase and created a number of recombinant ASNase products. The N24 residue on the flexible active loop was identified as the primary AEP cleavage site. Sole modification at this site rendered ASNase resistant to AEP cleavage and suggested a key role for the flexible active loop in determining ASNase activity. We therefore propose what we believe to be a novel mechanism of drug resistance to ASNase. Our results may help to identify alternative therapeutic strategies with the potential of further improving outcome in childhood ALL

Definição de problemas entre o cliente e o consultor

Inexistent

Group support systems : concepts to practice

Group support systems have been in existence for 40 years and have been applied widely since their inception. One particular realm is using group support systems(GSSs) for assisting managers who must negotiate the resolution of messy, complex, and/or strategic problems in order to achieve an agreed outcome. Taking cognizance of concepts such as procedural justice and boundary objects,as well as the underlying features of GSS, an intervention involving social and psychological negotiation is presented and examined. The case intervention deals with two organizations needing to move from adversarial modus operandi to a more productive and collaborative mode in order for both to operate more effectively. The intervention is presented in a chronological manner allowing particular phases to be explored, considered alongside research into the nature of failed decisions, group behaviors, and social and psychological negotiation, and a number of salient elements and their implications for facilitators are provided