Analyzing trauma in Toni Morrison’s "Beloved"

Trabajo de fin de Grado. Grado en Estudios Ingleses. Curso académico 2016-2017[EN]During cеnturiеs sеvеral pеoplе wеrе opprеssеd by othеr culturеs, thе rеpеrcussion of this influеncе and thе consеquеncеs such as trauma arе thе main topic of thе following tеxt whеrе it will bе еxplorе through thе quеstion of what is thе sciеncе of trauma and how this is showеd in Bеlovеd. This novеl is prеsеntеd as a paradigmatic еxamplе of thе еmеrging gеnrе of trauma fiction what makеs it an intеrеsting subjеct of study, еspеcially rеgarding thе charactеrs who will bе analyzеd in ordеr to find a bеttеr undеrstanding of trauma, how it affеcts thе individuals and how it hеals. [ES]Durantе siglos varios puеblos fuеron oprimidos por otras culturas, la rеpеrcusión dе еsta influеncia y las consеcuеncias como trauma son еl tеma principal dеl siguiеntе tеxto dondе sе еxplorará a través dе la cuеstión dе qué еs la ciеncia dеl trauma y como еsto еs rеprеsеntado еn Bеlovеd. Еsta novеla еs prеsеntada como un еjеmplo paradigmático dеl gеnеro еmеrgеntе quе еs la litеratura dеl trauma, lo quе lo conviеrtе еn un intеrеsantе sujеto dе еstudio, еspеcialmеntе еn rеlación con los pеrsonajеs los quе sеrán analizados para еncontrar una mеjor comprеnsión dе lo quе еs еl trauma, cómo afеcta a los individuos y como sana

La vida de las mujeres en las ciudades. Narcea, Madrid (1998). Chris Booth.Jane Darkey Susan Veandie (Coord.)

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El silencio administrativo: nuevo tratamiento legal (Ley 30/1992).

Sin resume

Smart Mesoporous Nanomaterials for Antitumor Therapy

The use of nanomaterials for the treatment of solid tumours is receiving increasing attention by the scientific community. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique features that make them suitable nanocarriers to host, transport and protect drug molecules until the target is reached. It is possible to incorporate different targeting ligands to the outermost surface of MSNs to selectively drive the drugs to the tumour tissues. To prevent the premature release of the cargo entrapped in the mesopores, it is feasible to cap the pore entrances using stimuli-responsive nanogates. Therefore, upon exposure to internal (pH, enzymes, glutathione, etc.) or external (temperature, light, magnetic field, etc.) stimuli, the pore opening takes place and the release of the entrapped cargo occurs. These smart MSNs are capable of selectively reaching and accumulating at the target tissue and releasing the entrapped drug in a specific and controlled fashion, constituting a promising alternative to conventional chemotherapy, which is typically associated with undesired side effects. In this review, we overview the recent advances reported by the scientific community in developing MSNs for antitumor therapy. We highlight the possibility to design multifunctional nanosystems using different therapeutic approaches aimed at increasing the efficacy of the antitumor treatment

Zwitterionic ceramics for biomedical applications

Bioceramics for bone tissue regeneration, local drug delivery and nanomedicine, are receiving growing attention by the biomaterials scientific community. The design of bioceramics with improved surface properties able to overcome clinical issues is a great scientific challenge. Zwitterionization of surfaces has arisen as a powerful alternative in the design of biocompatible bioceramics capable to inhibit bacterial and non-specific protein adsorption, which opens up new insights into the biomedical applications of these materials. This manuscript reviews the different approaches reported up to date for the synthesis and characterization of zwitterionic bioceramics with potential clinical applications. Statement of Significance Zwitterionic bioceramics are receiving growing attention by the biomaterials scientific community due to their great potential in bone tissue regeneration, local drug delivery and nanomedicines. Herein, the different strategies developed so far to synthesize and characterize zwitterionic bioceramics with potential clinical applications are summarized. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved

Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer

Introduction: Nanocarriers have emerged as a powerful alternative for cancer therapy.Indeed, they are promising candidates to tackle the acquired resistance of surviving cells against antiproliferative drugs – the so-called multidrug resistance (MDR) phenomenon – which has arisen as one of the major clinical issues of chemotherapy. Among nanocarriers, this review focuses on the recent approaches based on tailored mesoporous silica nanoparticles (MSNs) that could overcome this problem. Areas covered: Herein we summarize the current efforts developed to provide MSNbased nanosystems of enhanced dual therapeutic action against diseased cells. This can be accomplished by three main approaches: i) increasing nanosystems’ killing capability towards particular cells by enhancing both recognition and specificity; ii)increasing the apoptotic effect throughout co-delivery of several drugs; or iii)combining drug delivery with apoptosis induced by physical methods. Expert Opinion: The development of multifunctional nanosystems able to exert the optimal therapeutic action through the minimal administration constitutes a major challenge in nanomedicine. Recent developments in advanced MSN-based platforms for drug delivery represent promising avenues in the management of MDR associated with cancer therapy. All strategies discussed in this manuscript demonstrate improvements against difficult-to-treat tumors

Sensores basados en materiales híbridos organo-inorgánicos controlados por Inteligencia Artificial: aplicación al análisis de líquidos complejos

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Química Inorgánica. Fecha de lectura: 21-10-200

El silencio administrativo: nuevo tratamiento legal (Ley 30/1992).

Sin resume

Recent advances in mesoporous silica nanoparticles for antitumor therapy: our contribution

Since 2001, when our research group proposed for the first time MCM-41 as a drug release system, the scientific community has demonstrated a growing interest in mesoporous silica nanoparticles (MSNs) for their revolutionary potential in nanomedicine. Among the diverse pathologies that can be treated with MSNs, cancer has received increasing attention. MSNs can be loaded with large amounts of therapeutic cargoes and once intravenously administrated preferentially accumulate in solid tumours via the enhanced permeation and retention (EPR) effect. Herein we report the recent developments achieved by our research group as a pioneer in this field, highlighting: the design of sophisticated MSNs as stimuli-responsive drug delivery systems to release the entrapped cargo upon exposure to a given stimulus while preventing the premature release of highly cytotoxic drugs before reaching the target; transporting non-toxic prodrugs and the enzyme responsible for its conversion into cytotoxic agents into the same MSNs; improving the selectivity and cellular uptake by cancer cells by active targeting of MSNs; increasing the penetration of MSNs within the tumour mass, which is one of the major challenges in the use of NPs to treat solid tumours