249 research outputs found
Magnetic field tuning of coplanar waveguide resonators
We describe measurements on microwave coplanar resonators designed for
quantum bit experiments. Resonators have been patterned onto sapphire and
silicon substrates, and quality factors in excess of a million have been
observed. The resonant frequency shows a high sensitivity to magnetic field
applied perpendicular to the plane of the film, with a quadratic dependence for
the fundamental, second and third harmonics. Frequency shift of hundreds of
linewidths can be obtained.Comment: Accepted for publication in AP
On the properties of superconducting planar resonators at mK temperatures
Planar superconducting resonators are now being increasingly used at mK
temperatures in a number of novel applications. They are also interesting
devices in their own right since they allow us to probe the properties of both
the superconductor and its environment. We have experimentally investigated
three types of niobium resonators - including a lumped element design -
fabricated on sapphire and SiO_2/Si substrates. They all exhibit a non-trivial
temperature dependence of their centre frequency and quality factor. Our
results shed new light on the interaction between the electromagnetic waves in
the resonator and two-level fluctuators in the substrate.Comment: V2 includes some minor corrections/changes. Submitted to PR
Circuit QED with a Flux Qubit Strongly Coupled to a Coplanar Transmission Line Resonator
We propose a scheme for circuit quantum electrodynamics with a
superconducting flux-qubit coupled to a high-Q coplanar resonator. Assuming
realistic circuit parameters we predict that it is possible to reach the strong
coupling regime. Routes to metrological applications, such as single photon
generation and quantum non-demolition measurements are discussed.Comment: 8 pages, 5 figure
A Year in the Life of a Passive House with Solar Energy Store:International Conference on Sustainable Energy Storage, Belfast, Northern Ireland 21 to 23 February 2011
Meeting Residual Heat Loads in a Passivhaus Using Solar Energy and a Seasonal Store:CIBSE ASHRAE Technical Symposium, Imperial College, London 18th 19th April 2012
Improved genetic testing for monogenic diabetes using targeted next-generation sequencing
addresses: Institute for Biomedical and Clinical Science, University of Exeter Medical School, Barrack Road, Exeter EX2 5DW, UK. [email protected]: PMCID: PMC3737433types: Journal Article; Research Support, Non-U.S. Gov'tOpen Access ArticleCurrent genetic tests for diagnosing monogenic diabetes rely on selection of the appropriate gene for analysis according to the patient's phenotype. Next-generation sequencing enables the simultaneous analysis of multiple genes in a single test. Our aim was to develop a targeted next-generation sequencing assay to detect mutations in all known MODY and neonatal diabetes genes
Key features of palliative care service delivery to Indigenous peoples in Australia, New Zealand, Canada and the United States: A comprehensive review
Background: Indigenous peoples in developed countries have reduced life expectancies, particularly from chronic diseases. The lack of access to and take up of palliative care services of Indigenous peoples is an ongoing concern.
Objectives: To examine and learn from published studies on provision of culturally safe palliative care service delivery to Indigenous people in Australia, New Zealand (NZ), Canada and the United States of America (USA); and to compare Indigenous peoples’ preferences, needs, opportunities and barriers to palliative care.
Methods: A comprehensive search of multiple databases was undertaken. Articles were included if they were published in English from 2000 onwards and related to palliative care service delivery for Indigenous populations; papers could use quantitative or qualitative approaches. Common themes were identified using thematic synthesis. Studies were evaluated using Daly’s hierarchy of evidence-for-practice in qualitative research.
Results: Of 522 articles screened, 39 were eligible for inclusion. Despite diversity in Indigenous peoples’ experiences across countries, some commonalities were noted in the preferences for palliative care of Indigenous people: to die close to or at home; involvement of family; and the integration of cultural practices. Barriers identified included inaccessibility, affordability, lack of awareness of services, perceptions of palliative care, and inappropriate services. Identified models attempted to address these gaps by adopting the following strategies: community engagement and ownership; flexibility in approach; continuing education and training; a whole-of-service approach; and local partnerships among multiple agencies. Better engagement with Indigenous clients, an increase in number of palliative care patients, improved outcomes, and understanding about palliative care by patients and their families were identified as positive achievements.
Conclusions: The results provide a comprehensive overview of identified effective practices with regards to palliative care delivered to Indigenous populations to guide future program developments in this field. Further research is required to explore the palliative care needs and experiences of Indigenous people living in urban areas
Systematic population screening, using biomarkers and genetic testing, identifies 2.5% of the U.K. pediatric diabetes population with monogenic diabetes
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.OBJECTIVE: Monogenic diabetes is rare but is an important diagnosis in pediatric diabetes clinics. These patients are often not identified as this relies on the recognition of key clinical features by an alert clinician. Biomarkers (islet autoantibodies and C-peptide) can assist in the exclusion of patients with type 1 diabetes and allow systematic testing that does not rely on clinical recognition. Our study aimed to establish the prevalence of monogenic diabetes in U.K. pediatric clinics using a systematic approach of biomarker screening and targeted genetic testing. RESEARCH DESIGN AND METHODS: We studied 808 patients (79.5% of the eligible population) <20 years of age with diabetes who were attending six pediatric clinics in South West England and Tayside, Scotland. Endogenous insulin production was measured using the urinary C-peptide creatinine ratio (UCPCR). C-peptide-positive patients (UCPCR ≥0.2 nmol/mmol) underwent islet autoantibody (GAD and IA2) testing, with patients who were autoantibody negative undergoing genetic testing for all 29 identified causes of monogenic diabetes. RESULTS: A total of 2.5% of patients (20 of 808 patients) (95% CI 1.6-3.9%) had monogenic diabetes (8 GCK, 5 HNF1A, 4 HNF4A, 1 HNF1B, 1 ABCC8, 1 INSR). The majority (17 of 20 patients) were managed without insulin treatment. A similar proportion of the population had type 2 diabetes (3.3%, 27 of 808 patients). CONCLUSIONS: This large systematic study confirms a prevalence of 2.5% of patients with monogenic diabetes who were <20 years of age in six U.K. clinics. This figure suggests that ∼50% of the estimated 875 U.K. pediatric patients with monogenic diabetes have still not received a genetic diagnosis. This biomarker screening pathway is a practical approach that can be used to identify pediatric patients who are most appropriate for genetic testing.This work presents independent research
commissioned by the Health Innovation
Challenge Fund, a parallel funding partnership
between the Wellcome Trust and the Department
of Health (grant HICF-1009-041); and was
supported by the National Institute for Health
Research (NIHR) Exeter Clinical Research Facility
and the South West Peninsula Diabetes Research
Network. M.S. is supported by the NIHR Exeter
Clinical Research Facility. T.J.M. is funded by an
NIHR CSO Fellowship. S.E. and A.T.H. are both
Wellcome Trust Senior Investigators. E.R.P. is a
Wellcome Trust New Investigator. A.T.H. is an
NIHR Senior Investigator
Using digital technologies to facilitate social inclusion during the COVID-19 pandemic: Experiences of co-resident and non-co-resident family carers of people with dementia from DETERMIND-C19
Background
The COVID-19 pandemic triggered rapid and unprecedented changes in the use of digital technologies to support people's social inclusion. We examined whether and how co-resident and non-co-resident family carers of people with dementia engaged with digital technologies during this period.
Methods
Throughout November 2020-February 2021, we interviewed 42 family carers of people with dementia from our DETERMIND-C19 cohort. Preliminary analysis was conducted through Framework analysis, followed by an inductive thematic analysis.
Findings
Digital technologies served as a Facilitator for social inclusion by enabling carers to counter the effects of the differing restrictions imposed on them so they could remain socially connected and form a sense of solidarity, access resources and information, engage in social and cultural activities and provide support and independence in their caring role. However, these experiences were not universal as carers discussed some Challenges for tech inclusion, which included preferences for face-to-face contact, lack of technological literacy and issues associated with the accessibility of the technology.
Conclusion
Many of the carers engaged with Information and Communication Technologies, and to a lesser extent Assistive Technologies, during the pandemic. Whilst carers experienced different challenges due to where they lived, broadly the use of these devices helped them realise important facets of social inclusion as well as facilitated the support they provided to the person with dementia. However, to reduce the ‘digital divide’ and support the social inclusion of all dementia carers, our findings suggest it is essential that services are attuned to their preferences, needs and technological abilities
Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes
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