Acute cardiac effects of marathon running

We sought to clarify the significance of cardiac dysfunction and to assess its relationship with elevated biomarkers by using cardiovascular magnetic resonance imaging in healthy, middle-aged subjects immediately after they ran 26.2 miles. Cardiac dysfunction and elevated blood markers of myocardial injury have been reported after prolonged strenuous exercise. From 425 volunteers, 13 women and 12 men were randomly selected, provided medical and training history, and underwent baseline cardiopulmonary exercise testing to exhaustion. Blood biomarkers, cardiovascular magnetic resonance imaging, and 24-h ambulatory electrocardiography were performed 4 wk before and immediately after the race. Participants were 38.7 ± 9.0 yr old, had baseline peak oxygen consumption of 52.9 ± 5.6 ml·kg−1·min−1, and completed the marathon in 256.2 ± 43.5 min. Cardiac troponin I and B-type natriuretic peptide increased following the race ( P = 0.001 and P &lt; 0.0001, respectively). Cardiovascular magnetic resonance-determined pre- and postmarathon left ventricular ejection fractions were comparable, 57.7 ± 4.1% and 58.7 ± 4.3%, respectively ( P = 0.32). Right atrial volume index increased from 46.7 ± 14.4 to 57.0 ± 14.5 ml/m2( P &lt; 0.0001). Similarly, right ventricular end-systolic volume index increased from 47.4 ± 11.2 to 57.0 ± 14.6 ml/m2( P &lt; 0.0001) whereas the right ventricular ejection fraction dropped from 53.6 ± 7.1 to 45.5 ± 8.5% ( P &lt; 0.0001). There were no morphological changes observed in the left atrium or ventricle or evidence of ischemic injury to any chamber by late gadolinium enhancement. There were no significant arrhythmias. Marathon running causes dilation of the right atrium and right ventricle, reduction of right ventricular ejection fraction, and release of cardiac troponin I and B-type natriuretic peptide but does not appear to result in ischemic injury to any chamber.</jats:p

Red de municipios contra el síndrome metabólico

This paper is a proposal for intervention from the municipalities, the prevention and control of Metabolic Syndrome (SM), the detection of which uses national and international criteria; For its approach, the essential axes of Primary Health Care are adopted. Likewise, progress is made in intergovernmental, intersectoral and inter-institutional coordination, among which the constitution of the Network stands out, initially made up of Xalapa, Coatzacoalcos, Minatitlan, Jáltipan, Agua Dulce and Moloacán, municipalities where an Inter-institutional Table was established. This initiative has been joined by government institutions, non-governmental organizations, legislative representatives, professional societies and civil associations.Keywords: Municipalities; Metabolic Syndrome; Network; Primary Health CareResumen: El presente artículo presenta una propuesta de intervención desde los municipios, la prevención y control del Síndrome Metabólico (SM), cuya detección utilizan criterios nacionales e internacionales; para su abordaje se adoptan los ejes esenciales de la Atención Primaria de Salud. Asimismo, se presentan avances en materia de coordinación intergubernamental, intersectorial e interinstitucional, entre los que destaca la constitución de la Red integrada, inicialmente, por Xalapa, Coatzacoalcos, Minatitlán, Jáltipan, Agua Dulce y Moloacán, municipios donde se estableció una Mesa Interinstitucional. A esta iniciativa, se han sumado instituciones gubernamentales, organizaciones no gubernamentales, representantes legislativos, sociedades de profesionistas y asociaciones civiles

Red de Municipios Contra el Síndrome Metabólico

Resumen: El presente artículo presenta una propuesta de intervención desde los municipios, la prevención y control del Síndrome Metabólico (SM), cuya detección utilizan criterios nacionales e internacionales; para su abordaje se adoptan los ejes esenciales de la Atención Primaria de Salud. Asimismo, se presentan avances en materia de coordinación intergubernamental, intersectorial e interinstitucional, entre los que destaca la constitución de la Red integrada, inicialmente, por Xalapa, Coatzacoalcos, Minatitlán, Jáltipan, Agua Dulce y Moloacán, municipios donde se estableció una Mesa Interinstitucional. A esta iniciativa, se han sumado instituciones gubernamentales, organizaciones no gubernamentales, representantes legislativos, sociedades de profesionistas y asociaciones civiles.Palabras clave: Municipios, Síndrome, Metabólico, Red, Atención, Primaria AbstractThis paper is a proposal for intervention from the municipalities, the prevention and control of Metabolic Syndrome (SM), the detection of which uses national and international criteria; For its approach, the essential axes of Primary Health Care are adopted. Likewise, progress is made in intergovernmental, intersectoral and inter-institutional coordination, among which the constitution of the Network stands out, initially made up of Xalapa, Coatzacoalcos, Minatitlan, Jáltipan, Agua Dulce and Moloacán, municipalities where an Inter-institutional Table was established. This initiative has been joined by government institutions, non-governmental organizations, legislative representatives, professional societies and civil associations.Keywords: Municipalities; Metabolic Syndrome; Network; Primary Health Care</jats:p

Red de Municipios Contra el Síndrome Metabólico

Resumen: El presente artículo presenta una propuesta de intervención desde los municipios, la prevención y control del Síndrome Metabólico (SM), cuya detección utilizan criterios nacionales e internacionales; para su abordaje se adoptan los ejes esenciales de la Atención Primaria de Salud. Asimismo, se presentan avances en materia de coordinación intergubernamental, intersectorial e interinstitucional, entre los que destaca la constitución de la Red integrada, inicialmente, por Xalapa, Coatzacoalcos, Minatitlán, Jáltipan, Agua Dulce y Moloacán, municipios donde se estableció una Mesa Interinstitucional. A esta iniciativa, se han sumado instituciones gubernamentales, organizaciones no gubernamentales, representantes legislativos, sociedades de profesionistas y asociaciones civiles.Palabras clave: Municipios, Síndrome, Metabólico, Red, Atención, Primaria AbstractThis paper is a proposal for intervention from the municipalities, the prevention and control of Metabolic Syndrome (SM), the detection of which uses national and international criteria; For its approach, the essential axes of Primary Health Care are adopted. Likewise, progress is made in intergovernmental, intersectoral and inter-institutional coordination, among which the constitution of the Network stands out, initially made up of Xalapa, Coatzacoalcos, Minatitlan, Jáltipan, Agua Dulce and Moloacán, municipalities where an Inter-institutional Table was established. This initiative has been joined by government institutions, non-governmental organizations, legislative representatives, professional societies and civil associations.Keywords: Municipalities; Metabolic Syndrome; Network; Primary Health Care</jats:p

Degradation of textile dyes using immobilized lignin peroxidase-like metalloporphines under mild experimental conditions

<p>Abstract</p> <p>Background</p> <p>Synthetic dyes represent a broad and heterogeneous class of durable pollutants, that are released in large amounts by the textile industry. The ability of two immobilized metalloporphines (structurally emulating the ligninolytic peroxidases) to bleach six chosen dyes (alizarin red S, phenosafranine, xylenol orange, methylene blue, methyl green, and methyl orange) was compared to enzymatic catalysts. To achieve a green and sustainable process, very mild conditions were chosen.</p> <p>Results</p> <p>IPS/MnTSPP was the most promising biomimetic catalyst as it was able to effectively and quickly bleach all tested dyes. Biomimetic catalysis was fully characterized: maximum activity was centered at neutral pH, in the absence of any organic solvent, using hydrogen peroxide as the oxidant. The immobilized metalloporphine kept a large part of its activity during multi-cycle use; however, well-known redox mediators were not able to increase its catalytic activity. IPS/MnTSPP was also more promising for use in industrial applications than its enzymatic counterparts (lignin peroxidase, laccase, manganese peroxidase, and horseradish peroxidase).</p> <p>Conclusions</p> <p>On the whole, the conditions were very mild (standard pressure, room temperature and neutral pH, using no organic solvents, and the most environmental-friendly oxidant) and a significant bleaching and partial mineralization of the dyes was achieved in approximately 1 h. Therefore, the process was consistent with large-scale applications. The biomimetic catalyst also had more promising features than the enzymatic catalysts.</p