Microwave diode amplifiers with low intermodulation distortion

Distortions can be greatly reduced in narrow-band applications by using the second harmonic. The ac behavior of simplified diode amplifier has negative resistance depending on slope of equivalent I-V curve

On the Red-Green-Blue Model

We experimentally study the red-green-blue model, which is a sytem of loops obtained by superimposing three dimer coverings on offset hexagonal lattices. We find that when the boundary conditions are ``flat'', the red-green-blue loops are closely related to SLE_4 and double-dimer loops, which are the loops formed by superimposing two dimer coverings of the cartesian lattice. But we also find that the red-green-blue loops are more tightly nested than the double-dimer loops. We also investigate the 2D minimum spanning tree, and find that it is not conformally invariant.Comment: 4 pages, 7 figure

Acute complete heart block in dogs

A study has been conducted immediately and up to 18 days after the surgical production of complete heart block in dogs. Immediately after surgery cardiac output, coronary flow, and mean arterial pressure were reduced in rough proportion to the degree of bradycardia. In time, these measures began to return toward preoperative levels. Paralleling the diminished left ventricular work was a diminished left ventricular oxygen consumption with little consequent change in myocardial efficiency. Small rises were detected in central venous pressure. At autopsy, the only unequivocal abnormality was myocardial hypertrophy which became measurable between 2 and 18 days after operation

The Effects of Massive Substructures on Image Multiplicities in Gravitati onal Lenses

Surveys for gravitational lens systems have typically found a significantly larger fraction of lenses with four (or more) images than are predicted by standard ellipsoidal lens models (50% versus 25-30%). We show that including the effects of smaller satellite galaxies, with an abundance normalized by the observations, significantly increases the expected number of systems with more than two images and largely explains the discrepancy. The effect is dominated by satellites with ~20% the luminosity of the primary lens, in rough agreement with the typical luminosities of the observed satellites. We find that the lens systems with satellites cannot, however, be dropped from estimates of the cosmological model based on gravitational lens statistics without significantly biasing the results.Comment: 23 pages, 7 figures, more discussion of sis vs sie and inclusion of uncorrelated contribution

Hole Localization in Underdoped Superconducting Cuprates Near 1/8th Doping

Measurements of thermal conductivity versus temperature over a broad range of doping in YBa$_2$Cu$_3$O$_{6+x}$ and HgBa$_2$Ca$_{n-1}$Cu$_n$O$_{2n+2+\delta}$ ($n$=1,2,3) suggest that small domains of localized holes develop for hole concentrations near $p$=1/8. The data imply a mechanism for localization that is intrinsic to the CuO$_2$-planes and is enhanced via pinning associated with oxygen-vacancy clusters.Comment: 4 pages, 4 eps fig.'s, to be published, Phys. Rev.

Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinuation study.

BackgroundCabozantinib, an orally bioavailable inhibitor of tyrosine kinases including MET, AXL, and VEGF receptors, was assessed in patients with hepatocellular carcinoma (HCC) as part of a phase 2 randomized discontinuation trial with nine tumor-type cohorts.Patients and methodsEligible patients had Child-Pugh A liver function and ≤1 prior systemic anticancer regimen, completed ≥4 weeks before study entry. The cabozantinib starting dose was 100 mg daily. After an initial 12-week cabozantinib treatment period, patients with stable disease (SD) per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.0 were randomized to cabozantinib or placebo. The primary endpoint of the lead-in stage was objective response rate (ORR) at week 12, and the primary endpoint of the randomized stage was progression-free survival (PFS).ResultsAmong the 41 HCC patients enrolled, the week 12 ORR was 5%, with 2 patients achieving a confirmed partial response (PR). The week 12 disease control rate (PR or SD) was 66% (Asian subgroup: 73%). Of patients with ≥1 post-baseline scan, 78% had tumor regression, with no apparent relationship to prior sorafenib therapy. Alpha-fetoprotein (AFP) response (>50% reduction from baseline) occurred in 9 of the 26 (35%) patients with elevated baseline AFP and ≥1 post-baseline measurement. Twenty-two patients with SD at week 12 were randomized. Median PFS after randomization was 2.5 months with cabozantinib and 1.4 months with placebo, although this difference was not statistically significant. Median PFS and overall survival from Day 1 in all patients were 5.2 and 11.5 months, respectively. The most common grade 3/4 adverse events, regardless of attribution, were diarrhea (20%), hand-foot syndrome (15%), and thrombocytopenia (15%). Dose reductions were utilized in 59% of patients.ConclusionsCabozantinib has clinical activity in HCC patients, including objective tumor responses, disease stabilization, and reductions in AFP. Adverse events were managed with dose reductions.Trial registration numberNCT00940225

Faint X-ray Sources in the Globular Cluster Terzan 5

We report our analysis of a Chandra X-ray observation of the rich globular cluster Terzan 5, in which we detect 50 sources to a limiting 1.0-6 keV X-ray luminosity of 3*10^{31} ergs/s within the half-mass radius of the cluster. Thirty-three of these have L_X>10^{32} ergs/s, the largest number yet seen in any globular cluster. In addition to the quiescent low-mass X-ray binary (LMXB, identified by Wijnands et al.), another 12 relatively soft sources may be quiescent LMXBs. We compare the X-ray colors of the harder sources in Terzan 5 to the Galactic Center sources studied by Muno and collaborators, and find the Galactic Center sources to have harder X-ray colors, indicating a possible difference in the populations. We cannot clearly identify a metallicity dependence in the production of low-luminosity X-ray binaries in Galactic globular clusters, but a metallicity dependence of the form suggested by Jordan et al. for extragalactic LMXBs is consistent with our data.Comment: 15 pages, 10 figures (3 color). Resubmitted to ApJ after incorporating referee comments. v2: Added references to introductio

A simple proof of the Markoff conjecture for prime powers

We give a simple and independent proof of the result of Jack Button and Paul Schmutz that the Markoff conjecture on the uniqueness of the Markoff triples (a,b,c), where a, b, and c are in increasing order, holds whenever $c$ is a prime power.Comment: 5 pages, no figure