Analysis of the Power Quality Impact of Multiple Directed Energy Loads on an Electric Ship Power System

The electrical power system of an all-electric ship has been modeled in Simulink for the case of a ship supporting several high power directed energy loads, among which are a Free Electron Laser (FEL), an Active Denial System (ADS), and a Laser Weapon System (LaWS). Starting from a load centered approach, and a physical description of the components of the various loads, individual models of each load plus a combined model for a system supporting simultaneously one instance of all loads have been developed. Sample case studies are presented corresponding to expected operational scenarios for a US Navy ship and to potential emergency conditions. The models have been designed to be interactive, allowing the operator to change key settings dynamically while the simulation is running, thus mimicking an actual operation of the power system on a ship in real time. A preliminary graphical user interface has also been developed to demonstrate the ability of these models to be converted into top-level training tools for Navy personnel supported by a realistic representation of the ship power system

A stochastic quantum Krylov protocol with double factorized Hamiltonians

We propose a class of randomized quantum Krylov diagonalization (rQKD) algorithms capable of solving the eigenstate estimation problem with modest quantum resource requirements. Compared to previous real-time evolution quantum Krylov subspace methods, our approach expresses the time evolution operator, $e^{-i\hat{H} \tau}$, as a linear combination of unitaries and subsequently uses a stochastic sampling procedure to reduce circuit depth requirements. While our methodology applies to any Hamiltonian with fast-forwardable subcomponents, we focus on its application to the explicitly double-factorized electronic-structure Hamiltonian. To demonstrate the potential of the proposed rQKD algorithm, we provide numerical benchmarks for a variety of molecular systems with circuit-based statevector simulators, achieving ground state energy errors of less than 1~kcal~mol$^{-1}$ with circuit depths orders of magnitude shallower than those required for low-rank deterministic Trotter-Suzuki decompositions

Association of a Workplace Sales Ban on Sugar-Sweetened Beverages With Employee Consumption of Sugar-Sweetened Beverages and Health.

ImportanceReductions in sugar-sweetened beverage (SSB) intake can improve health, but are difficult for individuals to achieve on their own.ObjectivesTo evaluate whether a workplace SSB sales ban was associated with SSB intake and cardiometabolic health among employees and whether a brief motivational intervention provides added benefits to the sales ban.Design, setting, and participantsThis before-after study and additional randomized trial conducted from July 28, 2015, to October 16, 2016, at a Northern California university and hospital assessed SSB intake, anthropometrics, and cardiometabolic biomarkers among 214 full-time English-speaking employees who were frequent SSB consumers (≥360 mL [≥12 fl oz] per day) before and 10 months after implementation of an SSB sales ban in a large workplace, with half the employees randomized to receive a brief motivational intervention targeting SSB reduction.InterventionsThe employer stopped selling SSBs in all workplace venues, and half the sample was randomized to receive a brief motivational intervention and the other half was a control group that did not receive the intervention. This intervention was modeled on standard brief motivational interventions for alcohol used in the workplace that promote health knowledge and goal setting.Main outcomes and measuresOutcomes included changes in SSB intake, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and measures of abdominal adiposity. The primary associations tested were the correlation between changes in SSB intake and changes in HOMA-IR.ResultsAmong the 214 study participants, 124 (57.9%) were women, with a mean (SD) age of 41.2 (11.0) years and a baseline mean (SD) body mass index of 29.4 (6.5). They reported a mean daily intake of 1050 mL (35 fl oz) of SSBs at baseline and 540 mL (18 fl oz) at follow-up-a 510-mL (17-fl oz) (48.6%) decrease (P < .001). Reductions in SSB intake correlated with improvements in HOMA-IR (r = 0.16; P = .03). Those not randomized to receive the brief intervention reduced their SSB intake by a mean (SD) of 246.0 (84.0) mL (8.2 [2.8] fl oz), while those also receiving the brief intervention reduced SSB intake by 762.0 (84.0) mL (25.4 [2.8] fl oz). From baseline to follow-up, there were significant reductions in mean (SE) waist circumference (2.1 [2.8] cm; P < .001).Conclusions and relevanceThis study's findings suggest that the workplace sales ban was associated with a reduction in SSB intake and a significant reduction in waist circumference among employees within 10 months. The randomized clinical trial portion of this study found that targeting those at high risk with a brief motivational intervention led to additional improvements. Workplace sales bans may offer a promising new private-sector strategy for reducing the health harms of SSB intake.Trial registrationClinicalTrials.gov identifier: NCT02585336

Thermodynamics and collapse of self-gravitating Brownian particles in D dimensions

We address the thermodynamics (equilibrium density profiles, phase diagram, instability analysis...) and the collapse of a self-gravitating gas of Brownian particles in D dimensions, in both canonical and microcanonical ensembles. In the canonical ensemble, we derive the analytic form of the density scaling profile which decays as f(x)=x^{-\alpha}, with alpha=2. In the microcanonical ensemble, we show that f decays as f(x)=x^{-\alpha_{max}}, where \alpha_{max} is a non-trivial exponent. We derive exact expansions for alpha_{max} and f in the limit of large D. Finally, we solve the problem in D=2, which displays rather rich and peculiar features

Thermodynamics of self-gravitating systems

Self-gravitating systems are expected to reach a statistical equilibrium state either through collisional relaxation or violent collisionless relaxation. However, a maximum entropy state does not always exist and the system may undergo a ``gravothermal catastrophe'': it can achieve ever increasing values of entropy by developing a dense and hot ``core'' surrounded by a low density ``halo''. In this paper, we study the phase transition between ``equilibrium'' states and ``collapsed'' states with the aid of a simple relaxation equation [Chavanis, Sommeria and Robert, Astrophys. J. 471, 385 (1996)] constructed so as to increase entropy with an optimal rate while conserving mass and energy. With this numerical algorithm, we can cover the whole bifurcation diagram in parameter space and check, by an independent method, the stability limits of Katz [Mon. Not. R. astr. Soc. 183, 765 (1978)] and Padmanabhan [Astrophys. J. Supp. 71, 651 (1989)]. When no equilibrium state exists, our relaxation equation develops a self-similar collapse leading to a finite time singularity.Comment: 54 pages. 25 figures. Submitted to Phys. Rev.

Lenvatinib Plus Pembrolizumab in Patients With Advanced Endometrial Cancer.

PURPOSE: Patients with advanced endometrial carcinoma have limited treatment options. We report final primary efficacy analysis results for a patient cohort with advanced endometrial carcinoma receiving lenvatinib plus pembrolizumab in an ongoing phase Ib/II study of selected solid tumors. METHODS: Patients took lenvatinib 20 mg once daily orally plus pembrolizumab 200 mg intravenously once every 3 weeks, in 3-week cycles. The primary end point was objective response rate (ORR) at 24 weeks (ORR RESULTS: At data cutoff, 108 patients with previously treated endometrial carcinoma were enrolled, with a median follow-up of 18.7 months. The ORR CONCLUSION: Lenvatinib plus pembrolizumab showed promising antitumor activity in patients with advanced endometrial carcinoma who have experienced disease progression after prior systemic therapy, regardless of tumor MSI status. The combination therapy had a manageable toxicity profile