Accurate on-wafer power and harmonic measurements of mm-wave amplifiers and devices

A novel integrated test system that accurately measures on-wafer S-parameters, power levels, load-pull contours and harmonics over 1 to 50 GHz is presented. The system measures power and S-parameters with single contact measurements and integrated hardware. There are two keys to this system: first, the network analyzer samplers are used as frequency-selective power meters with large dynamic ranges; second, all measurements are vector-corrected to the device under test reference planes. The capabilities and accuracy were demonstrated by measuring the power at the fundamental frequency and four harmonic frequencies of a 50-GHz traveling wave amplifier and the load-pull contours of a MODFET at 30 GH

Nuclear astrophysics: Recent results on CNO-cycle reactions and AGB nucleosynthesis

Nuclear astrophysics aims to measure nuclear-reaction cross sections of astrophysical interest to be included into models to study stellar evolution and nucleosynthesis. Low energies, < 100 keV, are requested for this is the window where these processes are more effective. Two effects have prevented to achieve a satisfactory knowledge of the relevant nuclear processes, namely the Coulomb barrier exponentially suppressing the cross section and the presence of atomic electrons. These difficulties have triggered theoretical and experimental investigations to extend our knowledge down to astrophysical energies. For instance, indirect techniques such as the Trojan Horse Method and new experimental facilities such as deep underground laboratories have been devised yielding new cutting-edge results

Design of a Lambda system for population transfer in superconducting nanocircuits

The implementation of a Lambda scheme in superconducting artificial atoms could allow detec- tion of stimulated Raman adiabatic passage (STIRAP) and other quantum manipulations in the microwave regime. However symmetries which on one hand protect the system against decoherence, yield selection rules which may cancel coupling to the pump external drive. The tradeoff between efficient coupling and decoherence due to broad-band colored Noise (BBCN), which is often the main source of decoherence is addressed, in the class of nanodevices based on the Cooper pair box (CPB) design. We study transfer efficiency by STIRAP, showing that substantial efficiency is achieved for off-symmetric bias only in the charge-phase regime. We find a number of results uniquely due to non-Markovianity of BBCN, namely: (a) the efficiency for STIRAP depends essentially on noise channels in the trapped subspace; (b) low-frequency fluctuations can be analyzed and represented as fictitious correlated fluctuations of the detunings of the external drives; (c) a simple figure of merit for design and operating prescriptions allowing the observation of STIRAP is proposed. The emerging physical picture also applies to other classes of coherent nanodevices subject to BBCN.Comment: 14 pages, 11 figure

Determining the 13C(α, n)16O absolute cross section through the concurrent application of ANC and THM and astrophysical consequences for the s-process in AGB-LMSs.

The 13 C( α , n) 16 O reaction is considered to be the most important neutron source for the s -process main component in low-mass asymptotic giant branch stars. No direct experimental data exist at very low energies and measurements performed through direct techniques show inconsistent results, mostly in their absolute values. In this context, we reversed the usual normalization procedure combining two indirect approaches, the asymptotic normalization coefficient and the Trojan Horse Method, to unambiguously determine the absolute value of the 13 C( α , n) 16 O astrophysical S ( E )-factor in the most relevant energy-region for astrophysics. Adopting the new reaction rate for the n-source in the NEWTON s -process nucleosynthesis code, astrophysical calculations show only limited variations, less than 1%, for those nuclei whose production is considered to be totally due to slow neutron captures

First time evidence of pronounced plateaus right above the Coulomb barrier in 8Li + 4He fusion

We investigate unprecedented experimental information on the fusion reaction induced by the radioactive projectile 8 Li on a 4 He gas target, at center-of-mass energies between 0.6 and 5 MeV. The main issue is the tendency of the dimensionless fusion cross section σfπƛ2 to form well visible plateaus alternated to steep rises. This finding is likely to be the most genuine consequence of the discrete nature of the intervening angular momenta observed so far in fusion reactions right above the Coulomb barrier. A partial-wave analysis, exclusively based on a pure quantal penetration fusion model and sensitive to the interaction potential, identifies a remarkably low-height barrier

Correlation of Wissler Human Thermal Model Blood Flow and Shiver Algorithms

The Wissler Human Thermal Model (WHTM) is a thermal math model of the human body that has been widely used to predict the human thermoregulatory response to a variety of cold and hot environments. The model has been shown to predict core temperature and skin temperatures higher and lower, respectively, than in tests of subjects in crew escape suit working in a controlled hot environments. Conversely the model predicts core temperature and skin temperatures lower and higher, respectively, than in tests of lightly clad subjects immersed in cold water conditions. The blood flow algorithms of the model has been investigated to allow for more and less flow, respectively, for the cold and hot case. These changes in the model have yielded better correlation of skin and core temperatures in the cold and hot cases. The algorithm for onset of shiver did not need to be modified to achieve good agreement in cold immersion simulation

Human Thermal Model Evaluation Using the JSC Human Thermal Database

The human thermal database developed at the Johnson Space Center (JSC) is used to evaluate a set of widely used human thermal models. This database will facilitate a more accurate evaluation of human thermoregulatory response using in a variety of situations, including those situations that might otherwise prove too dangerous for actual testing--such as extreme hot or cold splashdown conditions. This set includes the Wissler human thermal model, a model that has been widely used to predict the human thermoregulatory response to a variety of cold and hot environments. These models are statistically compared to the current database, which contains experiments of human subjects primarily in air from a literature survey ranging between 1953 and 2004 and from a suited experiment recently performed by the authors, for a quantitative study of relative strength and predictive quality of the models. Human thermal modeling has considerable long term utility to human space flight. Such models provide a tool to predict crew survivability in support of vehicle design and to evaluate crew response in untested environments. It is to the benefit of any such model not only to collect relevant experimental data to correlate it against, but also to maintain an experimental standard or benchmark for future development in a readily and rapidly searchable and software accessible format. The Human thermal database project is intended to do just so; to collect relevant data from literature and experimentation and to store the data in a database structure for immediate and future use as a benchmark to judge human thermal models against, in identifying model strengths and weakness, to support model development and improve correlation, and to statistically quantify a model s predictive quality

Big Bang nucleosynthesis revisited via Trojan Horse Method measurements

Nuclear reaction rates are among the most important input for understanding the primordial nucleosynthesis and therefore for a quantitative description of the early Universe. An up-to-date compilation of direct cross sections of 2H(d,p)3H, 2H(d,n)3He, 7Li(p,alpha)4He and 3He(d,p)4He reactions is given. These are among the most uncertain cross sections used and input for Big Bang nucleosynthesis calculations. Their measurements through the Trojan Horse Method (THM) are also reviewed and compared with direct data. The reaction rates and the corresponding recommended errors in this work were used as input for primordial nucleosynthesis calculations to evaluate their impact on the 2H, 3,4He and 7Li primordial abundances, which are then compared with observations.Comment: 22 pages, 7 figures, accepted for publication in The Astrophysical Journa

Genetics of Parkinson’s Disease: The Role of Copy Number Variations

Parkinson’s disease (PD), the second most common progressive neurodegenerative disorder, was long believed to be a non-genetic sporadic origin syndrome. The identification of distinct genetic loci responsible for rare Mendelian forms of PD has represented a revolutionary breakthrough, allowing to discover novel mechanisms underlying this debilitating still incurable condition. Along with single-nucleotide polymorphisms (SNPs), other kinds of DNA molecular defects have emerged as significant disease-causing mutations, including large chromosomic structural rearrangements and copy number variations (CNVs). Due to their size variability and to the different sensitivity and resolution of detection methodologies, CNVs constitute a particular challenge in genetic studies and the pathogenetic or susceptibility impact of specific CNVs on PD is currently under debate. In this chapter, we will review the current literature and bioinformatic data describing the involvement of CNVs on PD pathobiology. We will discuss the recently highlighted role of PARK2 heterozygous CNVs, the possible common founder effects of PD gene rearrangements and the importance to map genetic breakpoints. We will also add a summary about the current available molecular methods and bioinformatics web resources to detect and interpret CNVs. Assessing the global genome-wide burden of large CNVs and elucidating the role of de novo rare structural variants on PD may reveal new candidate genes and consequently ameliorate diagnosis and counselling of mutations carriers