19 research outputs found

    The Use of Sulfasalazine in Atrophie Blanche

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    Atrophie blanche can be a chronic condition for which there is no satisfactory treatment. Two patients with atrophie blanche who had not responded to various therapeutic modalities were given a trial of sulfasalazine 1 g three times daily. The ulcers healed within 3 months in both cases. In view of these positive results, patients should be treated with sulfasalazine to determine the efficacy of this drug in atrophie blanche.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65527/1/j.1365-4362.1990.tb02594.x.pd

    PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER

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    BACKGROUND: Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE isoform with 40- to 100-fold greater affinity for cAMP than PDE4. Thus, we postulated that PDE8 is an important regulator of Teff cell functions. METHODOLOGY/PRINCIPAL FINDINGS: We found that Teff cells express PDE8 in vivo. Inhibition of PDE8 by the PDE inhibitor dipyridamole (DP) activates cAMP signaling and suppresses two major integrins involved in Teff cell adhesion. Accordingly, DP as well as the novel PDE8-selective inhibitor PF-4957325-00 suppress firm attachment of Teff cells to endothelial cells. Analysis of downstream signaling shows that DP suppresses proliferation and cytokine expression of Teff cells from Crem-/- mice lacking the inducible cAMP early repressor (ICER). Importantly, endothelial cells also express PDE8. DP treatment decreases vascular adhesion molecule and chemokine expression, while upregulating the tight junction molecule claudin-5. In vivo, DP reduces CXCL12 gene expression as determined by in situ probing of the mouse microvasculature by cell-selective laser-capture microdissection. CONCLUSION/SIGNIFICANCE: Collectively, our data identify PDE8 as a novel target for suppression of Teff cell functions, including adhesion to endothelial cells

    Retrograde Elektrostimulation des Magens mittels Schrittmacher zur Gewichtsreduktion?:Eine tierexperimentelle Studie am Schwein

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    Die morbide Adipositas ist nur durch chirurgische Maßnahmen wirkungsvoll zu behandeln. Hier wird eine chirurgische Technik zur Therapie der morbiden Adipositas im Tierexperiment an sechs Schweinen vorgestellt: Die retrograde Elektrostimulation am Magen mittels Schrittmacher. Sechs Tiere der Studiengruppe wurden mit jeweils einem Magenschrittmacher versehen. Sie wurden zusammen mit sechs weiteren scheinoperierten Schweinen (Kontrollgruppe) unter ad libitum- Fütterung über einem Zeitraum von 3 Monaten beobachtet. Studiengruppe: in der Phase des ausgeschalteten Schrittmachers (OFF) nahmen alle Schweine zwischen 3,7% und 19,52% an Gewicht zu. In der Phase des Angeschalteten Schrittmachers (ON): Gewichtsabnahme zwischen 2,82% und 5,85%. Kontrollgruppe: kontinuierliche Körpergewichtszunahme über den gesamten Versuchszeitraum Futterkonsum: Studiengruppe: sank in ON ab, während es in OFF wieder anstieg; Kontrollgruppe: Futterkonsumanstieg. Die Ergebnisse sind signifikant (p< 0,05)

    Lymphocyte Membrane Modifications induced by Acetylsalicylic Acid and Dipyridamole

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    Dipyridamole

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    Mittelgesichtsdistraktion mittels externen Gestells ohne Maxillaosteotomie

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