Chagas' disease and ageing: the coexistence of other chronic diseases with Chagas' disease in elderly patients Doença de Chagas e envelhecimento: a associação de outras enfermidades crônicas em pacientes idosos chagásicos

This study aimed to identify the main comorbidities in elderly chagasic patients treated in a reference service and identify possible associations between the clinical form of Chagas' disease and chronic diseases. Ninety patients aged 60 years-old or over were interviewed and their clinical diagnoses recorded. The study population profile was: women (55.6%); median age (67 years); married (51.1%); retired (73.3%); up to four years' education (64.4%); and earning less than two minimum wages (67.8%). The predominant forms of Chagas' disease were the cardiac (46.7%) and mixed forms (30%). There was a greater proportion of mild cardiac dysfunction (84.1%), frequently in association with megaesophagus. The mean number of concurrent diseases was 2.856 ± 1.845, and 33% of the patients had four or more comorbidities. The most frequent were systemic arterial hypertension (56.7%), osteoporosis (23.3%), osteoarthritis (21.2%) and dyslipidemia (20%). Positive correlations were verified between sex and comorbidities and between age group and comorbidities.<br>Este trabalho objetivou avaliar o perfil sociodemográfico e identificar as principais co-morbidades de idosos chagásicos, buscando associação entre forma clínica da doença de Chagas e enfermidades crônicas. Foi realizada entrevista e levantamento dos diagnósticos clínicos de 90 chagásicos com idade > 60 anos. Encontrou-se: mulheres (55,6%), mediana de 67 anos, casados (51,1%) e renda mensal inferior a dois salários-mínimos (67,8%). A forma clínica predominante foi a cardíaca (46,7%), seguida da mista (30%). Houve maior proporção de cardiopatia leve (84,1%), sendo frequente a associação com megaesôfago. Trinta e três por cento apresentavam quatro ou mais co-morbidades, dentre elas: hipertensão arterial (56,7%), osteoporose (23,3%), osteoartrite (21,2%) e dislipidemia (20%). Obteve-se correlação positiva entre gênero e co-morbidades, faixa etária e co-morbidades

Measurement of the cross section for tt‾ \mathrm{t}\overline{\mathrm{t}} production with additional jets and b jets in pp collisions at s \sqrt{s} = 13 TeV

Measurements of the cross section for the production of top quark pairs in association with a pair of jets from bottom quarks $$\left({\sigma}_{\mathrm{t}\overline{\mathrm{t}}\mathrm{b}\overline{\mathrm{b}}}\right)$$and in association with a pair of jets from quarks of any flavor or gluons $$\left({\sigma}_{\mathrm{t}\overline{\mathrm{t}}\mathrm{jj}}\right)$$and their ratio are presented. The data were collected in proton-proton collisions at a center-of-mass energy of 13 TeV by the CMS experiment at the LHC in 2016 and correspond to an integrated luminosity of 35.9 fb−1. The measurements are performed in a fiducial phase space and extrapolated to the full phase space, separately for the dilepton and lepton+jets channels, where lepton corresponds to either an electron or a muon. The results of the measurements in the fiducial phase space for the dilepton and lepton+jets channels, respectively, are $${\sigma}_{\mathrm{t}\overline{\mathrm{t}}\mathrm{jj}}$$= 2.36±0.02 (stat)±0.20 (syst) pb and 31.0±0.2 (stat)±2.9 (syst) pb, and for the cross section ratio 0.017 ± 0.001 (stat) ± 0.001 (syst) and 0.020 ± 0.001 (stat) ± 0.001 (syst). The values of $${\sigma}_{\mathrm{t}\overline{\mathrm{t}}\mathrm{b}\overline{\mathrm{b}}}$$are determined from the product of the $${\sigma}_{\mathrm{t}\overline{\mathrm{t}}\mathrm{jj}}$$and the cross section ratio, obtaining, respectively, 0.040±0.002 (stat)±0.005 (syst) pb and 0.62±0.03 (stat)±0.07 (syst) pb. These measurements are the most precise to date and are consistent, within the uncertainties, with the standard model expectations obtained using a matrix element calculation at next-to-leading order in quantum chromodynamics matched to a parton shower