Conjunto de viviendas - Barcelona – España

This article presents a preliminary study of a typical giant block from which conclusions and practical applications are drawn for many other cases. &#13; The many contrasts of the planform and façades endows the unit with great gracefulness and a most dynamic impression, avoiding the monotony that the repetition of a module usually implies. &#13; A great diversity of the types of housing and the possibility of easy variations have been achieved, with gardens nearby and a subterranean parking lot, with great capacity, under the walks for pedestrians.<br><br>Se presenta en este artículo el estudio de una supermanzana, de la cual se sacan conclusiones y aplicaciones prácticas para muchos casos. &#13; La gran movilidad de las plantas y alzados presta una gracia y una dinámica de gran efecto al conjunto, evitando la monotonía que habitualmente se deduce de la repetición de un módulo. &#13; Se ha conseguido una gran diversidad de tipos de viviendas y la posibilidad de fáciles variantes, con zonas verdes próximas a ellas y aparcamiento subterráneo, de gran capacidad, bajo las calles peatonales. Antes de entrar en la descripción del grupo de viviendas que se exponen en este artículo, se hace la exposición somera de una supermanzana tipo, con cuya construcción se está llevando a cabo investigaciones interesantes, a base de una trama urbana con calles en curva de gran circulación y calles rectas de longitud limitada, calles y plazas

Vivienda unifamiliar en Barcelona – España

This permanent residence was constructed on a lot with a large number of trees in the Bonanova «Ciudad Jardín». &#13; The different areas of the program are distributed on its three levels in a clearly differentiated manner. Thus, in the semibasement, the general installations are found; on the ground floor,, the living areas, bedrooms and servants' quarters, adequately communicated; and on the top leveí, overlooking the surrounding panorama, the master suite.&#13; In the architectural treatment, the large Windows of the ground floor stand out which, at the same time as they integrate the combination of the brick surface with the numerous bodies which project and jut inward brought about by the irregularity of the floor plans.&lt;br&gt;&lt;br&gt;En una parcela profusamente arbolada, de la Ciudad Jardín de Bonanova, se ha realizado esta vivienda. &#13; En sus tres niveles distribuye las distintas dependencias del programa de forma claramente diferenciada. Así, en el semisótano se encuentran las instalaciones generales; en la planta baja las zonas nobles, de dormitorios y de servicio, adecuadamente comunicadas entre sí; y en el nivel superior, dominando el panorama circundante, la suite del matrimonio. &#13; En el tratamiento arquitectónico sobresalen los grandes ventanales de la planta baja que, al tiempo que integran el ajardinamiento con las habitaciones, resaltan los numerosos cuerpos entrantes y salientes originados por la irregularidad de las plantas

Vivienda unifamiliar en Barcelona – España

This permanent residence was constructed on a lot with a large number of trees in the Bonanova «Ciudad Jardín». The different areas of the program are distributed on its three levels in a clearly differentiated manner. Thus, in the semibasement, the general installations are found; on the ground floor,, the living areas, bedrooms and servants' quarters, adequately communicated; and on the top leveí, overlooking the surrounding panorama, the master suite. In the architectural treatment, the large Windows of the ground floor stand out which, at the same time as they integrate the combination of the brick surface with the numerous bodies which project and jut inward brought about by the irregularity of the floor plans.En una parcela profusamente arbolada, de la Ciudad Jardín de Bonanova, se ha realizado esta vivienda. En sus tres niveles distribuye las distintas dependencias del programa de forma claramente diferenciada. Así, en el semisótano se encuentran las instalaciones generales; en la planta baja las zonas nobles, de dormitorios y de servicio, adecuadamente comunicadas entre sí; y en el nivel superior, dominando el panorama circundante, la suite del matrimonio. En el tratamiento arquitectónico sobresalen los grandes ventanales de la planta baja que, al tiempo que integran el ajardinamiento con las habitaciones, resaltan los numerosos cuerpos entrantes y salientes originados por la irregularidad de las plantas

Sede del Instituto Francés, 1972 Barcelona-España

Instead of linking with the building existing on the same lot, according to the project of City Hall, the headquarters of the French Institute has been carried out separately, even though area approved for building has been sacrificed way it was felt that this was the only way to provide it witch a nature in accordance with its functional purpose, without having to relate it in any way whatsoever to the other construction, which has a completely different use. It consists of: basement, for parking and facilities; ground floor with mezzanine, occupied by the administration, secretariat and living quarters for the concierge; six upper floors, with classrooms; and a top floor, offset, which houses the living quarters of the director. In its composition as regards the facade, the garden with the rooms, emphasize the narrow vertical empty spaces stands out, lending the building its marked personality.En lugar de enlazar con el edificio existente en el mismo solar, según el proyecto del Ayuntamiento, la sede del Instituto Francés se ha realizado exenta, aun perdiendo edificabilidad, por considerarse que era la única forma de conferirle un carácter acorde con su funcionalidad, sin tener que relacionarse de alguna manera con la otra construcción, de uso radicalmente distinto. Consta de: 2 sótanos, dedicados a garaje e instalaciones; planta baja con entreplanta, ocupadas por la administración, secretaría y vivienda del conserje; seis plantas superiores, con los locales de enseñanza; y una última planta, retranqueada, que aloja la vivienda del director. En su composición exterior sobresale la combinación de la plaqueta cerámica, con los estrechos huecos verticales, que otorga al edificio su marcada personalidad

Vivienda unifamiliar en Madrid – España

In this home are repeated once again characteristics which are common to the works of Coderch, such as the numerous variations in level and the irregularities of the floor plan, motivated in this case by an adaptation to the uneven surface of the land and the complexity of the program proposed by the owner. In the one-story home, the proper internal functioning stands out, as well as the creation of a pleasant atmosphere within the framework of a sobriety of lines.En esta vivienda se repiten, una vez más, características que son comunes en las obras de Coderch, como los numerosos escalonamientos y las irregularidades de la planta, motivados, en este caso, por la adaptación a los desniveles del terreno y por la complejidad del programa propuesto por la propiedad. En la vivienda, de una sola planta, destaca el correcto funcionamiento interior, así como la creación de agradables ambientes dentro de una sobriedad de líneas

Liposome formation with wool lipid extracts rich in ceramides

Internal wool lipids (IWLs) are rich in cholesterol, free fatty acids, cholesteryl sulfate, and, mainly, ceramides. The repairing effect of these lipids structured as liposomes was demonstrated by reinforcing the skin-barrier integrity and increasing the water-holding capacity when applied onto the skin. This work was focused on the formation of liposomes with IWLs rich in ceramides, obtained at pilot plant level with organic solvent extraction by using methanol and acetone. The lipid composition of the two extracts was quantitatively analyzed. IWL extracts containing different amounts of sterol sulfate were used to form liposomes at physiologic pH. Vesicle size distribution, polydispersity index, and zeta potential of all liposomes were determined to characterize them and to study their stability. The results obtained showed that IWL extract composition, which was different depending on the extraction methodologies used, greatly influences the characteristics of the liposomes formed. Vesicular size and polydispersity index liposomes were smaller when the extract composition contained a higher proportion of either free fatty acids or sterol sulfate. Moreover, liposome stability was improved when some amount of sterol sulfate was added to the composition of methanol and acetone extracts. This natural mixture with keratinaceous origin could have a special interest for cosmetic or dermopharmaceutical companies.We acknowledge Mr. G. von Knorring for his expert technical assistance. We are also indebted to the DGICYT Program (PPQ 2002-94136-C02-01 and C02-02) for financial support

Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a &#181;Hair Follicle 3D Model

The hair follicle (HF) is a dynamic \u201cmini-organ\u201d which undergoes bi-continuous cycles of growth, destruction and rest. The molecular mechanisms underlying the HF cycle are complex yet not fully understood. Anyhow, it is clear that the epithelial\u2013mesenchymal interactions, and in particular the cross-talk between dermal papilla fibroblast (DPF) and the keratinocytes of the outer root sheath (ORSK) play a pivotal role. Aim of this study is the evaluation of the biological activity of anisotropic osmolyte solutions on the HF cycle. As reported in recent studies, dermal papilla cells deeply modify their gene expression profile when cultured as monolayers, but their transcriptional pattern can be partially restored when they are cultured as 3-dimensional spheroids. This draws our attention to the discovery that the spatial distribution of cells in the growth medium is fundamental in order to produce a verisimilar model. Therefore, we used the hanging drop technology to produce a scaffold-free micro-tissue model applied to a DPF-ORSK co-culture in order to create a \u3bcHF 3-dimensional model. As a result, this system was capable of evaluating the efficacy of the anisotropic osmolyte solutions on the progressive increase of the follicle turnover and \u2018health\u2019. Moreover, an in silico model was used in order to screen the most promising combination of osmolyte molecules. In vivo objective evaluations were finally carried out on volunteers having hair disorders

Asymptotic Expansions for Stationary Distributions of Perturbed Semi-Markov Processes

New algorithms for computing of asymptotic expansions for stationary distributions of nonlinearly perturbed semi-Markov processes are presented. The algorithms are based on special techniques of sequential phase space reduction, which can be applied to processes with asymptotically coupled and uncoupled finite phase spaces.Comment: 83 page