Correlation Scales of the Turbulent Cascade at 1 au

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Turbulence-driven ion beams in the magnetospheric Kelvin-Helmholtz instability

The description of the local turbulent energy transfer via a heuristic proxy derived from the third-order moment scaling law, and the high-resolution ion distributions measured by the Magnetospheric Multiscale mission, together provide a formidable tool to explore the cross-scale connection between the fluid-scale energy cascade and plasma processes at sub-ion scales. Using magnetospheric boundary layers measurements, we show that when the small-scale energy transfer is dominated by Alfvénic, correlated velocity and magnetic field fluctuations, beams of accelerated particles are more likely observed. Here, for the first time we report observations suggesting the nonlinear wave-particle interaction as one possible mechanism for the energy dissipation in space plasmas

Energy Transfer in Incompressible Magnetohydrodynamics: The Filtered Approach

We develop incompressible magnetohydrodynamic (IMHD) energy budget equations with a spatial filtering kernel and estimate the scaling of the structure functions. The Politano-Pouquet law is recovered as an upper bound on the scale-to-scale energy transfer. The primary result of this work is the relation of the scaling of IMHD invariants. It can be produced by hypothesizing a scale-independent energy transfer rate. These results have relevance in plasma regimes where the approximations of IMHD are justified. We measure structure functions with solar wind data and find support for the relations

Tumor Suppressor Function of the Plasma Glutathione Peroxidase Gpx3 in Colitis-Associated Carcinoma

The glutathione peroxidases, a family of selenocysteine-containing redox enzymes, play pivotal roles in balancing the signaling, immunomodulatory and deleterious effects of reactive oxygen species (ROS). The glutathione peroxidase GPX3 is the only extracellular member of this family, suggesting it may defend cells against ROS in the extracellular environment. Notably, GPX3 hypermethylation and underexpression occurs commonly in prostate, gastric, cervical, thyroid and colon cancers. We took a reverse genetics approach to investigate whether GPX3 would augment inflammatory colonic tumorigenesis, a process characterized by oxidative stress and inflammation, comparing Gpx3(−/−) mice established two-stage model of inflammatory colon carcinogenesis. Gpx3-deficient mice exhibited an increased tumor number, though not size, along with a higher degree of dysplasia. Additionally, they exhibited increased inflammation with redistribution towards pro-tumorigenic M2 macrophage subsets, increased proliferation, hyperactive WNT signaling, and increased DNA damage. To determine the impact of acute gene loss in an established colon cancer line, we silenced GPX3 in human Caco2 cells, resulting in increased ROS production, DNA damage and apoptosis in response to oxidative stress, combined with decreased contact-independent growth. Taken together, our results suggested an immunomodulatory role for GPX3 that limits the development of colitis-associated carcinoma