Problem detection in legislative oversight:An analysis of legislative committee agendas in the U.K. and U.S.

This paper outlines a dynamic problem-detection model of legislative oversight where legislative committees engage in information-gathering to identify emerging policy problems. It is argued that activities of legislative committees are responsive to indicators of problem status across a range of policy domains. This enables committees to react to problems before, or at least simultaneously to, citizens. Our analyses use a new dataset on the policy agenda of UK Parliamentary Select Committees in combination with directly comparable data on US Congressional hearings. Aggregate measures of problem status (e.g. GDP, crime rates) and public opinion on the �most important problem� facing the country are used as independent variables. The comparison between a well-established and developing committee system offers insights into common dynamics across institutional contexts. The findings show that committee agendas in both the UK and US are responsive to problem status for the majority of issues

Genotoxic effect induced by hydrogen peroxide in human hepatoma cells using comet assay

Background: Hydrogen peroxide is a common reactive oxygen intermediate generated by variousforms of oxidative stress. Aims: The aim of this study was to investigate the DNA damage capacity ofH2O2 in HepG2 cells. Methods: Cells were treated with H2O2 at concentrations of 25 μM or 50 μM for5 min, 30 min, 40 min, 1 h or 24 h in parallel. The extent of DNA damage was assessed by the cometassay. Results: Compared to the control, DNA damage by 25 μM and 50 μM H2O2 increasedsignificantly with increasing incubation time up to 1 h, but it was not increased at 24 h. Conclusions:Our Findings confirm that H2O2 is a typical DNA damage inducing agent and thus is a good modelsystem to study the effects of oxidative stress. DNA damage in HepG2 cells increased significantlywith H2O2 concentration and time of incubation but later decreased likely due to DNA repairmechanisms and antioxidant enzyme

The agenda of British government: the speech from the throne, 1911-2008

This article considers how UK governments use the Speech from the Throne (also known as the Gracious Speech and the King's or the Queen's Speech) to define and articulate their executive and legislative agenda. The analysis uses the policy content coding system of the Policy Agendas Project to measure total executive and legislative attention to particular issues. This generates the longest known data series of the political agenda in the UK, from the date of the first Parliament Act in 1911 right up to the end of 2008, nearly a century of government agenda setting. Using these data, the article identifies long-run institutional and policy stability in this agenda-setting instrument, and variation in its length and executive–legislative content due to the focusing events of world wars and party control of government. It assesses the degree to which the policy content of the speech is persistent (autoregressive) over time and identifies long-term trends in the total number of topics mentioned in each speech (scope), and the dispersion of government attention across topics (entropy). It also identifies important variation over time that indicates change in the agenda-setting function of the speech and evolution of the agenda in response to policy challenges faced by modern British governments in the period since 1911. Overall, the analysis demonstrates the robustness of the speech as a measure of the policy agenda and executive priorities in the UK