Substituting Data Annotation with Balanced Updates and Collective Loss in Multi-label Text Classification

Multi-label text classification (MLTC) is the task of assigning multiple labels to a given text, and has a wide range of application domains. Most existing approaches require an enormous amount of annotated data to learn a classifier and/or a set of well-defined constraints on the label space structure, such as hierarchical relations which may be complicated to provide as the number of labels increases. In this paper, we study the MLTC problem in annotation-free and scarce-annotation settings in which the magnitude of available supervision signals is linear to the number of labels. Our method follows three steps, (1) mapping input text into a set of preliminary label likelihoods by natural language inference using a pre-trained language model, (2) calculating a signed label dependency graph by label descriptions, and (3) updating the preliminary label likelihoods with message passing along the label dependency graph, driven with a collective loss function that injects the information of expected label frequency and average multi-label cardinality of predictions. The experiments show that the proposed framework achieves effective performance under low supervision settings with almost imperceptible computational and memory overheads added to the usage of pre-trained language model outperforming its initial performance by 70\% in terms of example-based F1 score.Comment: Proc. Conf. Lifelong Learning Agents (CoLLAs), 202

Common Ravens Disrupt Greater Sage-grouse Lekking Behavior in the Great Basin, USA

Expansion of human enterprise has contributed to increased abundance and distribution of common ravens (Corvus corax; ravens) across sagebrush (Artemisia spp.) ecosystems within western North America. Ravens are highly effective nest predators of greater sage-grouse (Centrocercus urophasianus; sage-grouse), a species of high conservation concern. Sage-grouse population trends are estimated using count survey data of males attending traditional breeding grounds, known as leks. We sought to investigate associations of ravens to sage-grouse lek sites and document interactions between the sage-grouse and ravens as well as those between sage-grouse and other animals observed around leks. First, we used extensive raven point counts and sage-grouse lek observation data collected across Nevada and California, USA, from 2009–2019 to evaluate spatial associations between sage-grouse and ravens while accounting for other environmental covariates. We found that ravens were more likely to be observed closer to lek sites, especially as leks increased in size. Second, we used a subset of the lek dataset from 2006–2019 to describe behavioral changes of male sage-grouse in the presence of ravens and other predators. Our analysis indicated that ravens are attracted to lek sites and were associated with disrupting lekking sage-grouse by causing flushes or ceasing displaying behaviors. These results suggest that adult and yearling sage-grouse perceive ravens as a reason to alter breeding activity, and ravens may adversely influence their reproduction during the lekking stage. Additionally, standardized techniques to count sage-grouse on leks for population trend analyses could be biased low if raven presence during surveys is not accounted for

Effects of Common Ravens on Greater Sage-Grouse in the Great Basin, Region, USA

Anthropogenic modification to ecosystems can result in the redistribution of species at higher trophic levels. Humans have re-organized predator-prey dynamics, namely by removing top predators and subsidizing more generalist mesocarnivore species. As a result, some mid-level predator species have increased in abundance and distribution, often to the detriment of lower-level species that are not adapted to increased predation rates. One example of a native avian predator that has experienced population increase following increased anthropogenic subsidization is the common raven (Corvus corax; hereafter, raven).The raven is an ubiquitous predator within sagebrush ecosystems in the western U.S.,and may contribute to suppressed population growth in greater sage-grouse (Centrocercus urophasianus) through disruptions to lekking behavior and top-down influences on nest success and recruitment. Ravens have expanded in distribution and abundance, in large part due to increased resource subsidies from human infrastructure and land use activities. Concurrently, some sage-grouse populations appear to be in decline where habitat conditions should be promoting species persistence. Using long-term monitoring data on sage-grouse and ravens in the northern Great Basin region, we show that ravens disrupt sage-grouse lekking behavior, increased raven density is associated with reduced sage-grouse nest success, and that negative trends in lek counts may be related to elevated raven occurrence and density. Taken together, these results suggest the need to address a growing problem, as ravens continue to expand their distribution, facilitated by anthropogenic subsidies. These findings are preliminary and provided to meet the need for timely best science

Fine Selmer Groups and Isogeny Invariance

We investigate fine Selmer groups for elliptic curves and for Galois representations over a number field. More specifically, we discuss Conjecture A, which states that the fine Selmer group of an elliptic curve over the cyclotomic extension is a finitely generated $\mathbb{Z}_p$-module. The relationship between this conjecture and Iwasawa's classical $\mu=0$ conjecture is clarified. We also present some partial results towards the question whether Conjecture A is invariant under isogenies.Comment: 20 page

A new intracellular serine protease inhibitor expressed in the rat pituitary gland complexes with granzyme B

AbstractWe have cloned a novel serpin (raPIT5a) from a rat pituitary cDNA library which is structurally related to members of the ovalbumin subfamily of serine protease inhibitors. This new cDNA encodes a 374-amino acid protein, designated raPIT5a. raPIT5a was expressed in specific cells in the intermediate and anterior lobes of the pituitary. Recombinant raPIT5a was not secreted suggesting raPIT5a functions to inhibit intracellular proteases. Recombinant raPIT5a formed an SDS-stable complex with human granzyme B, a serine protease which induces apoptosis by activating members of the caspase enzyme family. These data suggest raPIT5a may have a role in regulating granzyme B or related enzymes and apoptosis in the pituitary gland

Gender differences in perceptions of psoriatic arthritis disease impact, management, and physician interactions: results from a global patient survey

Introduction: We evaluated the impact of gender on disease severity, health-related quality of life (HRQoL), treatment management, and patient–healthcare professional (HCP) interactions from the perspectives of patients with psoriatic arthritis (PsA). Methods: Data were collected from a global online patient survey conducted by The Harris Poll (November 2, 2017 to March 12, 2018). Eligible patients were aged ≥ 18 years, with a self-reported diagnosis of PsA for > 1 year, had visited a rheumatologist/dermatologist in the past 12 months, and had reported previously using ≥ 1 conventional synthetic or biologic disease-modifying antirheumatic drug. Data were stratified by gender and analyzed descriptively, inferentially by binomial (chi-square) tests, and by multivariate logistic regression models. Results: Data from 1286 patients who participated were included: 52% were female, 48% were male. Varying perceptions of disease severity between males and females were indicated by differences in symptoms leading to a diagnosis of PsA, and in symptoms reported despite treatment; more females than males reported joint tenderness, skin patches/plaques, and enthesitis. More females than males reported a major/moderate impact of PsA on their physical activity and emotional/mental well-being. Reasons for switching medication differed between genders, with more females switching because they perceived their medication to not be effective enough related to their joint symptoms. More females than males were very satisfied with their communication with their rheumatologist and were more likely to discuss the impact of PsA on their daily lives, their treatment satisfaction, and treatment goals with their rheumatologist. Conclusions:Patients’ perceptions of the impact of PsA on HRQoL, treatment management, and interactions with HCPs varied between males and females. More females than males reported major/moderate physical and emotional impacts of PsA. When treating patients, it is important for HCPs to consider the potential impact of gender on patients’ experience of PsA and its symptoms. Graphical plain language summary available for this article

Performance of composite measures used in a trial of etanercept and methotrexate as monotherapy or in combination in psoriatic arthritis

Objectives: To examine which composite measures are most sensitive to change when measuring psoriatic arthritis (PsA) disease activity, analyses compared the responsiveness of composite measures used in a 48-week randomized, controlled trial of MTX and etanercept in patients with PsA. Methods: The trial randomised 851 patients to receive weekly: MTX (20 mg/week), etanercept (50 mg/week) or MTX plus etanercept. Dichotomous composite measures examined included ACR 20/50/70 responses, minimal disease activity (MDA) and very low disease activity (VLDA). Continuous composite measures examined included Disease Activity Score (28 joints) using CRP (DAS28-CRP), Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI), Disease Activity for Psoriatic Arthritis (DAPSA) and Psoriatic Arthritis Disease Activity Score (PASDAS). Results: At week 24, etanercept-treated groups were significantly more effective than MTX monotherapy to achieve ACR 20 (primary end point) and MDA (key secondary end point). When examining score changes from baseline at week 24 across the five continuous composite measures, PASDAS demonstrated relatively greater changes in the etanercept-treated groups compared with MTX monotherapy and had the largest effect size and standardized response. Joint count changes drove overall score changes at week 24 from baseline in all the continuous composite measures except for PASDAS, which was driven by the Physician and Patient Global Assessments. Conclusion: PASDAS was the most sensitive continuous composite measure examined with results that mirrored the protocol-defined primary and key secondary outcomes. Composite measures with multiple domains, such as PASDAS, may better quantify change in PsA disease burden. Trail registration: https://ClinicalTrials.gov, number NCT02376790

Electro-acupuncture and Chinese herbs for treatment of cervical intervertebral disk disease in a dog

A non-ambulatory dog with tetraparesis following a pain episode that had evolved over 2 months was submitted for medical treatment and diagnosed with intervertebral disk disease at C3-C4 and dorsal extradural compression at C1-C2 and C3-C4 using myelography and computed tomography. The dog experienced ambulation recovery after 15 days of treatment with only electroacupuncture and Chinese herbal medicine, with marked improvement occurring after only 10 treatments. Six months of follow-up demonstrated that the dog was stable and had no recurrence of symptoms. Therefore, it was concluded that the combination of electroacupuncture and Chinese herbal medicine was responsible for motor rehabilitation