Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules.

Covalent post-translational modification (PTM) of proteins with acyl groups of various carbon chain-lengths regulates diverse biological processes ranging from chromatin dynamics to subcellular localization. While the YEATS domain has been found to be a prominent reader of acetylation and other short acyl modifications, whether additional acyl-lysine reader domains exist, particularly for longer carbon chains, is unclear. Here, we employed a quantitative proteomic approach using various modified peptide baits to identify reader proteins of various acyl modifications. We discovered that proteins harboring HEAT and ARM repeats bind to lysine myristoylated peptides. Recombinant HEAT and ARM repeats bind to myristoylated peptides independent of the peptide sequence or the position of the myristoyl group. Indeed, HEAT and ARM repeats bind directly to medium- and long-chain free fatty acids (MCFA and LCFA). Lipidomic experiments suggest that MCFAs and LCFAs interact with HEAT and ARM repeat proteins in mammalian cells. Finally, treatment of cells with exogenous MCFAs and inhibitors of MCFA-CoA synthases increase the transactivation activity of the ARM repeat protein β-catenin. Taken together, our results suggest an unappreciated role for fatty acids in the regulation of proteins harboring HEAT or ARM repeats

An Evaluation of the Calderdale Warm Spaces 2022/23 Provision

The cost-of-living crisis has led to many people across the UK struggling to pay for essentials such as heating or eating. For those who were already living in poverty, increasing costs have brought additional challenges. Calderdale Council recognised the added challenges local people are facing and implemented a number of initiatives to support them. One initiative funded Voluntary, Community and Social Enterprise (VCSE) organisations to provide Warm Spaces. Warm Spaces, or warm hubs, are safe and friendly places where someone can go to keep warm during the day, throughout the winter months

Photon polarization in radiative B decays

We study decay distributions in B -> K pi pi gamma, combining contributions from several overlapping resonances in a K pi pi mass range near 1400 MeV, (1^+) K_1(1400), (2^+) K^*_2(1430) and (1^-) K^*(1410). A method is proposed for using these distributions to determine a photon polarization parameter in the effective radiative weak Hamiltonian. This parameter is measured through an up-down asymmetry of the photon direction relative to the K pi pi decay plane. We calculate a dominant up-down asymmetry of 0.33 +- 0.05 from the K1(1400) resonance, which can be measured with about 10^8 B B-bar pairs, thus providing a new test for the Standard Model and a probe for some of its extensions.Comment: 22 pages, 3 figures, version to appear in Phys. Rev.

Form factors of heavy-to-light B decays at large recoil

General relations between the form factors of B decays to light mesons are derived using the heavy quark and large recoil expansion. On their basis the complete account of contributions of second order in the ratio of the light meson mass to the large recoil energy is performed. Both ground and excited final meson states are considered. It is shown that most of the known form factor relations remain valid after the inclusion of quadratic mass corrections. The validity of some of such relations requires additional equalities for the helicity amplitudes. It is found that all these relations and equalities are fulfilled in the relativistic quark model based on the quasipotential approach in quantum field theory. The contribution of 1/m_b corrections to the branching fraction of the rare radiative B decay is discussed.Comment: 23 pages, revte

An Optimal Self-Stabilizing Firing Squad

Consider a fully connected network where up to $t$ processes may crash, and all processes start in an arbitrary memory state. The self-stabilizing firing squad problem consists of eventually guaranteeing simultaneous response to an external input. This is modeled by requiring that the non-crashed processes "fire" simultaneously if some correct process received an external "GO" input, and that they only fire as a response to some process receiving such an input. This paper presents FireAlg, the first self-stabilizing firing squad algorithm. The FireAlg algorithm is optimal in two respects: (a) Once the algorithm is in a safe state, it fires in response to a GO input as fast as any other algorithm does, and (b) Starting from an arbitrary state, it converges to a safe state as fast as any other algorithm does.Comment: Shorter version to appear in SSS0

Executive Summary of Evaluation of the Calderdale Warm Spaces 2022/23 Provision

The cost-of-living crisis has led to many people across the UK struggling to pay for essentials such as heating or eating. For those who were already living in poverty, increasing costs have brought additional challenges. Calderdale Council recognised the added challenges local people are facing and implemented a number of initiatives to support them. One initiative funded Voluntary, Community and Social Enterprise (VCSE) organisations to provide Warm Spaces. Warm Spaces, or warm hubs, are safe and friendly places where someone can go to keep warm during the day, throughout the winter months

Possible Supersymmetric Effects on Angular Distributions in B→K∗(→Kπ)ℓ+ℓ−B \to K^* (\to K \pi) \ell^+ \ell^- Decays

We investigate the angular distributions of the rare B decay, $B \to K^* (\to K \pi) \ell^+ \ell^-$, in general supersymmetric extensions of the standard model. We consider the new physics contributions from the operators $O_{7,8,9,10}$ in small invariant mass region of lepton pair. We show that the azimuthal angle distribution of the decay can tell us the new physics effects clearly from the behavior of the distribution, even if new physics does not change the decay rate substantially from the standard model prediction

Measuring the Photon Helicity in Radiative B Decays

We propose a way of measuring the photon polarization in radiative B decays into K resonance states decaying to K\pi\pi, which can test the Standard Model and probe new physics. The photon polarization is shown to be measured by the up-down asymmetry of the photon direction relative to the K\pi\pi decay plane in the K resonance rest frame. The integrated asymmetry in K_1(1400)\to K\pi\pi, calculated to be 0.34\pm 0.05 in the Standard Model, is measurable at currently operating B factories.Comment: 4 pages, final version to appear in Physical Review Letter

1/m_Q Corrections to the Heavy-to-Light-Vector Transitions in the HQET

Within the HQET, the heavy to light vector meson transitions are systematically analyzed to the order of 1/m_Q. Besides the four universal functions at the leading order, there are twenty-two independent universal form factors at the order of 1/m_Q. Both the semileptonic decay B->\rho which is relevant to the |V_{ub}| extraction, and the penguin induced decay B -> K^* which is important to new physics discovering, depend on these form factors. Phenomenological implications are discussed.Comment: RevTeX, 9 pages, no figure