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Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules.
Covalent post-translational modification (PTM) of proteins with acyl groups of various carbon chain-lengths regulates diverse biological processes ranging from chromatin dynamics to subcellular localization. While the YEATS domain has been found to be a prominent reader of acetylation and other short acyl modifications, whether additional acyl-lysine reader domains exist, particularly for longer carbon chains, is unclear. Here, we employed a quantitative proteomic approach using various modified peptide baits to identify reader proteins of various acyl modifications. We discovered that proteins harboring HEAT and ARM repeats bind to lysine myristoylated peptides. Recombinant HEAT and ARM repeats bind to myristoylated peptides independent of the peptide sequence or the position of the myristoyl group. Indeed, HEAT and ARM repeats bind directly to medium- and long-chain free fatty acids (MCFA and LCFA). Lipidomic experiments suggest that MCFAs and LCFAs interact with HEAT and ARM repeat proteins in mammalian cells. Finally, treatment of cells with exogenous MCFAs and inhibitors of MCFA-CoA synthases increase the transactivation activity of the ARM repeat protein β-catenin. Taken together, our results suggest an unappreciated role for fatty acids in the regulation of proteins harboring HEAT or ARM repeats
An Evaluation of the Calderdale Warm Spaces 2022/23 Provision
The cost-of-living crisis has led to many people across the UK struggling to pay for essentials such as heating or eating. For those who were already living in poverty, increasing costs have brought additional challenges. Calderdale Council recognised the added challenges local people are facing and implemented a number of initiatives to support them. One initiative funded Voluntary, Community and Social Enterprise (VCSE) organisations to provide Warm Spaces. Warm Spaces, or warm hubs, are safe and friendly places where someone can go to keep warm during the day, throughout the winter months
Photon polarization in radiative B decays
We study decay distributions in B -> K pi pi gamma, combining contributions
from several overlapping resonances in a K pi pi mass range near 1400 MeV,
(1^+) K_1(1400), (2^+) K^*_2(1430) and (1^-) K^*(1410). A method is proposed
for using these distributions to determine a photon polarization parameter in
the effective radiative weak Hamiltonian. This parameter is measured through an
up-down asymmetry of the photon direction relative to the K pi pi decay plane.
We calculate a dominant up-down asymmetry of 0.33 +- 0.05 from the K1(1400)
resonance, which can be measured with about 10^8 B B-bar pairs, thus providing
a new test for the Standard Model and a probe for some of its extensions.Comment: 22 pages, 3 figures, version to appear in Phys. Rev.
Form factors of heavy-to-light B decays at large recoil
General relations between the form factors of B decays to light mesons are
derived using the heavy quark and large recoil expansion. On their basis the
complete account of contributions of second order in the ratio of the light
meson mass to the large recoil energy is performed. Both ground and excited
final meson states are considered. It is shown that most of the known form
factor relations remain valid after the inclusion of quadratic mass
corrections. The validity of some of such relations requires additional
equalities for the helicity amplitudes. It is found that all these relations
and equalities are fulfilled in the relativistic quark model based on the
quasipotential approach in quantum field theory. The contribution of 1/m_b
corrections to the branching fraction of the rare radiative B decay is
discussed.Comment: 23 pages, revte
An Optimal Self-Stabilizing Firing Squad
Consider a fully connected network where up to processes may crash, and
all processes start in an arbitrary memory state. The self-stabilizing firing
squad problem consists of eventually guaranteeing simultaneous response to an
external input. This is modeled by requiring that the non-crashed processes
"fire" simultaneously if some correct process received an external "GO" input,
and that they only fire as a response to some process receiving such an input.
This paper presents FireAlg, the first self-stabilizing firing squad algorithm.
The FireAlg algorithm is optimal in two respects: (a) Once the algorithm is
in a safe state, it fires in response to a GO input as fast as any other
algorithm does, and (b) Starting from an arbitrary state, it converges to a
safe state as fast as any other algorithm does.Comment: Shorter version to appear in SSS0
Executive Summary of Evaluation of the Calderdale Warm Spaces 2022/23 Provision
The cost-of-living crisis has led to many people across the UK struggling to pay for essentials such as heating or eating. For those who were already living in poverty, increasing costs have brought additional challenges. Calderdale Council recognised the added challenges local people are facing and implemented a number of initiatives to support them. One initiative funded Voluntary, Community and Social Enterprise (VCSE) organisations to provide Warm Spaces. Warm Spaces, or warm hubs, are safe and friendly places where someone can go to keep warm during the day, throughout the winter months
Possible Supersymmetric Effects on Angular Distributions in Decays
We investigate the angular distributions of the rare B decay, , in general supersymmetric extensions of the standard
model. We consider the new physics contributions from the operators
in small invariant mass region of lepton pair. We show that the
azimuthal angle distribution of the decay can tell us the new physics effects
clearly from the behavior of the distribution, even if new physics does not
change the decay rate substantially from the standard model prediction
Measuring the Photon Helicity in Radiative B Decays
We propose a way of measuring the photon polarization in radiative B decays
into K resonance states decaying to K\pi\pi, which can test the Standard Model
and probe new physics. The photon polarization is shown to be measured by the
up-down asymmetry of the photon direction relative to the K\pi\pi decay plane
in the K resonance rest frame. The integrated asymmetry in K_1(1400)\to
K\pi\pi, calculated to be 0.34\pm 0.05 in the Standard Model, is measurable at
currently operating B factories.Comment: 4 pages, final version to appear in Physical Review Letter
1/m_Q Corrections to the Heavy-to-Light-Vector Transitions in the HQET
Within the HQET, the heavy to light vector meson transitions are
systematically analyzed to the order of 1/m_Q. Besides the four universal
functions at the leading order, there are twenty-two independent universal form
factors at the order of 1/m_Q. Both the semileptonic decay B->\rho which is
relevant to the |V_{ub}| extraction, and the penguin induced decay B -> K^*
which is important to new physics discovering, depend on these form factors.
Phenomenological implications are discussed.Comment: RevTeX, 9 pages, no figure
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