15 research outputs found
Arteriovenous malformation presenting with trigeminal neuralgia and treated with endovascular coiling
Mononuclear cell infiltrate, HLA-Dr expression and proliferation in 37 acoustic schwannomas
Frozen sections from 37 schwannomas
of the V111 nerve were reacted with a panel of
monoclonal antibodies to macrophage, lymphocyte,
I-ILA-Dr invariant chain and nuclear proliferation
antigens. A moderate number of rnacrophages was
demonstrated in 96% of tumours. CD8- and CD4-
lymphocytes were detected in slightly smaller numbers
in up to 87% and 23% of tumours respectively.
B-lyrnphocytes were present in only 2/32 cases
and NK-cells were absent from all 16 cases tested.
HLA-Dr antigen was expressed by macrophages in most
cases and by tumour cells in 13/24 tumours. These
findings may represent evidence for a degree of cellular
immune response. Occasional cells featuring nuclear
proliferation were detected in 15/27 cases
lmmunohistological signposts in central nervous system tumours with neuronal differentiation
25 neuronal tumours with a panel of
antibodies were studied and it was found that vimentin
was present in 15 tumours. It was also found in a few cells
within rosettes. PGP 9.5 showed a somatic pattern of
staining with nuclear and perinuclear positivity in 23.
Neurofilament reactivity was found in 14. Retina1
S-antigen was detected only in one medulloblastoma,
314 pineal tumours and 212 retinoblastomas. Reactivity.
for synaptophysin was present in 215 medulloblastomas,
3/10 neuroblastomas and 212 retinoblastomas. GFAP
was demonstrated in scattered tumour cells in 415
medulloblastomas. Two of these were the only tumours
featuring bipolar differentiation whilst it was unipolar in
the remainder. The significance of these findings in
relation to the ontogeny of these tumours is discussed
Haemangioblastoma, Histological and immunohistological study of an enigmatic cerebellar tumour
Paraffin-embedded blocks of 36 cerebellar
haemangioblastomas were reacted with a panel of
antibodies including glial fibrillary acidic protein,
vimentin, epithelial membrane antigen, cytokeratin,
Factor VIII, a neuroendocrine marker and with Ulex
europaeus. agglutinin The main histological features,
apart from the characteristic large abnormal vessels,
were a prominent reticulin network, a cystic architecture
and cellular and nuclear polymorphism. Two cell types
were identified: endothelial and stromal. Twenty
tumours were positive for glial fibrillary acidic protein
because of included or reactive astrocytes as well as
positive stromal cells. Vimentin was positive in all
tumours with a diffuse distribution and a somatic
pattern; blood vessels, stromal cells and reactive
astrocytes were strongly positive. Factor V111 and Ulex
europaeus agglutinin reactivity were present in a similar
pattern of staining in endothelium and in five cases there
were stromal cells that were positive with the latter.
We were not able to ascertain the histogenesis of the
stromal cell, which remains enigmatic