Spirituality, Spiritual Care Perceptions and Moral Sensitivity of Senior Nursing Students: A Multicenter and Cross-Sectional Study

Aim: The objective of this study was to investigate the perception of spiritual care and moral sensitivity of senior nursing students receiving education in five different regions of Turkiye. Method: This study used a multicenter, descriptive and cross-sectional survey design.Data were collected with the Spirituality and Spiritual Care Rating Scale and the Moral Sensitivity Questionnaire in the research. A total of 590 senior nursing students, studying in five different universities in five different regions of Turkiye, participated in this research. Results: The mean total score of students on the Spirituality and Spiritual Care Rating Scale was 4.06±0.70 and Moral Sensitivity Questionnaire was 5.44±1.12. There was a significant relationship between the mean total scores on the Spirituality and Spiritual Care Rating Scale and the Moral Sensitivity Questionnaire (p<0.05). Conclusion:It is recommended to benefit from different and innovative educational practices related to spirituality and moral sensitivity in nursing education, and to conduct interventional and longitudinal studies on these issues

Antioxidant and anti-inflammatory activities of a commercial noni juice revealed by carrageenan-induced paw edema

This study aimed to investigate antioxidant and anti-inflammatory activities of a commercial product of noni (Morinda citrifolia) juice. Carrageenan-induced rat paw edema was employed as inflammatory model. One control and three experimental groups were formed. Experimental groups were administered noni juice alone, noni juice+carrageenan, and carrageenan alone. Oxidant and antioxidant capacity were determined by d-ROMs test and BAP test, respectively. Plasma concentrations of endothelin-1 and leptin were measured by ELISA. Measurements were performed at zero time and 2nd hour of inflammation. Oxidant capacity decreased in noni-received groups at 2nd hour (p=0.019). Antioxidant capacity of the group which received noni alone was found to be higher at 2nd hour (p=0.036). Plasma concentrations of endothelin-1 and leptin were notably lower in noni-received groups (p=0.001 and p=0.021, respectively). The results show that the commercial noni juice investigated has pronounced antioxidant and anti-inflammatory activities

Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases

Background: Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative analysis of human clinical data and animal studies have contributed to a better understanding of the molecular and cellular pathways involved in the progression of NDDs. Previously, we have reported that the combined metabolic activators (CMA), which include the precursors of nicotinamide adenine dinucleotide and glutathione can be utilized to alleviate metabolic disorders by activating mitochondrial metabolism. Methods: We first analysed the brain transcriptomics data from AD patients and controls using a brain-specific genome-scale metabolic model (GEM). Then, we investigated the effect of CMA administration in animal models of AD and PD. We evaluated pathological and immunohistochemical findings of brain and liver tissues. Moreover, PD rats were tested for locomotor activity and apomorphine-induced rotation. Findings: Analysis of transcriptomics data with GEM revealed that mitochondrial dysfunction is involved in the underlying molecular pathways of AD. In animal models of AD and PD, we showed significant damage in the high-fat diet groups' brain and liver tissues compared to the chow diet. The histological analyses revealed that hyperemia, degeneration and necrosis in neurons were improved by CMA administration in both AD and PD animal models. These findings were supported by immunohistochemical evidence of decreased immunoreactivity in neurons. In parallel to the improvement in the brain, we also observed dramatic metabolic improvement in the liver tissue. CMA administration also showed a beneficial effect on behavioural functions in PD rats. Interpretation: Overall, we showed that CMA administration significantly improved behavioural scores in parallel with the neurohistological outcomes in the AD and PD animal models and is a promising treatment for improving the metabolic parameters and brain functions in NDDs.PoLiMeR Innovative Training Network ; SNIC ; ScandiBio Therapeutics ; ScandiBio Therapeutics and Knut ; Knut och Alice Wallenbergs Stiftels

Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: A randomised, double-blinded, placebo-controlled phase-II trial

Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed that CMA improves the AD-associated histological parameters in the animals. CMA promotes mitochondrial fatty acid uptake from the cytosol, facilitates fatty acid oxidation in the mitochondria, and alleviates oxidative stress. Methods: Here, we designed a randomised, double-blinded, placebo-controlled phase-II clinical trial and studied the effect of CMA administration on the global metabolism of AD patients. One-dose CMA included 12.35 g L-serine (61.75%), 1 g nicotinamide riboside (5%), 2.55 g N-acetyl-L-cysteine (12.75%), and 3.73 g L-carnitine tartrate (18.65%). AD patients received one dose of CMA or placebo daily during the first 28 days and twice daily between day 28 and day 84. The primary endpoint was the difference in the cognitive function and daily living activity scores between the placebo and the treatment arms. The secondary aim of this study was to evaluate the safety and tolerability of CMA. A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efficacy of the CMA in AD patients. Results: We showed a significant decrease of AD Assessment Scale-cognitive subscale (ADAS-Cog) score on day 84 vs day 0 (P = 0.00001, 29% improvement) in the CMA group. Moreover, there was a significant decline (P = 0.0073) in ADAS-Cog scores (improvement of cognitive functions) in the CMA compared to the placebo group in patients with higher ADAS-Cog scores. Improved cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging analysis. Moreover, the plasma levels of proteins and metabolites associated with NAD + and glutathione metabolism were significantly improved after CMA treatment. Conclusion: Our results indicate that treatment of AD patients with CMA can lead to enhanced cognitive functions and improved clinical parameters associated with phenomics, metabolomics, proteomics and imaging analysis. Trial registration ClinicalTrials.gov NCT04044131 Registered 17 July 2019, https://clinicaltrials.gov/ct2/show/NCT04044131

The effects of the rifampicin on the neuroregeneration in in vitro axotomy

Rifampisin, Nocardia meditterranei fermantasyon ürünü olan geniş spektrumlu antibiyotik sınıfı rifamisinlerin yarı sentetik bir türevidir. En yüksek serum konsantrasyonuna ağızdan alındıktan 1-4 saat sonra ulaşır ve plazma yarı ömrü 2-5 saattir. Son zamanlarda üzerinde durulan önemli özelliklerinden birisi anti-oksidan ve nöroprotektif etkinliğidir. Yapılan pek çok çalışma rifampisinin mitokondriyal oksidatif stresin bastırılması ve serbest radikal süpürücü etkisi ile nöroproteksiyon sağladığı sonucuna varmıştır. Serbest radikal süpürme kabiliyetinin yanı sıra, rifampisin'in çeşitli pro ve anti apoptotik proteinler aracılığıyla apoptozu engelleyebileceği gösterilmiştir. Pro-apoptotik Bax'ın ekspresyonunu azalttığı ve Bcl2, Bcl-XL, XIAP, cIAP2, FLIPs gibi anti-apoptotik gen ürünlerinin ekspresyonunu arttırdığı gösterilmiştir. Rifampisinin etkinliğini vurgulayan çalışmalar ışığında bu projede akson hasarı sonrasında meydana gelen dejeneratif değişikliklere karşın rifampisinin nöroprotektif, serbest radikal süpürücü ve antiapoptotik etkilerinin, in vitro aksotomi modelinde nörorejenerasyona etkisinin araştırılması planlandı. Çalışma kapsamında 0-1 günlük yenidoğan farelerden çıkartılan kortikal nöronlar primer hücre kültüründe yaşatıldı. Ardından in vitro hücre kültürlerine 1, 10 ve 100 µM rifampisin eklendi. Laser aksotomi protokolüyle aksonal hasar verildi. Dejenerasyona verilen aksonal yanıt mikroskopik görüntüleme ve propidium iyodür (PI) boyaması ile izlendi. PI boyama sonrasında yapılan analizlerde tüm RİF gruplarında hücresel canlılık aksotomi kontrol grubuyla kıyaslandığında artış gösterdi; ancak, bu etki RİF dozundan bağımsızdı.Rifampicin is a semisynthetic derivative of the rifamycins, a class of broad-spectrum antibiotics that are fermentation products of Nocardia meditterranei. Rifampicin reaches maximal serum concentration in 1–4 h after application and its plasma halflife is 2–5 h. One of the important features that have recently been reported is the antioxidant and neuroprotective activity of rifampicin. Many studies have concluded that rifampicin provides neuroprotection by suppressing mitochondrial oxidative stress and free radical scavenging effect. In addition to the effect of free radical scavenging, rifampicin has been shown to downregulate the expression of pro-apoptotic Bax and upregulate the expression of anti-apoptotic gene products such as Bcl-2, Bcl-XL, XIAP, cIAP2, FLIPs. The effects of neuroprotective, free radical scavenging and antiapoptotic effects on neuroregeneration in in vitro axotomy model were planned to investigate the effects of rifampicin. In our study, we aim to remove cortical neurons from 0-1 day old newborn mice in order to provide a live primary neuronal cell culture. After 1-10 and 100 µM rifampicin applied to the in vitro cell cultures, instructed the axonal damage via predefined laser axotomy protocol, and the axonal response to axotomy driven degeneration monitored by microscopic imaging and Propidium iodide staining. After PI staining, cell viability in all RIF groups increased compared to the axotomy control group, but this increase was not continued in a dose dependent manner

İstanbul’ da hadis/sünnet kültürü araştırmaları

TEZ ÖZETİİslâm toplumlarını gerek derûnî (inanç) gerekse günlük yaşantı(amel) yönünden dokuyan ve donatan Kitap-Sünnet ikilisidir. Birincisi(Kitap) ilke, ikincisi (Sünnet) uygulama ağırlıklı olarak toplumu inşa eder.İslâmî ilimler, söz konusu yapılanmanın kendi alanlarında nasıl cereyan ettiği, etmesi gerektiği ile ilgilidir. Zira İslâm hayat dinidir. Din ise, amel/uygulama ile toplumsal varlığını ispat ve ızhar eder. Bu açıdan bakıldığında din, tam anlamıyla sosyolojik bir fenomen/varlık ve gerçektir.İslâm toplumlarındaki sosyolojik olguları, İslâm kültürü emek olan Sünnet yönlendiregelmiştir. İslâm'ın bir toplumdaki izlerini, aynı zamanda Sünnet'in topluma kazandırdıkları olarak algılamak asla yanlış ya da abartı değildir.Köken olarak Hz. Peygamber'in mirası demek olan Sünnet'i, bize taşıyan ve tanıtan ise Hadis dediğimiz, belli forma sahip yazılı metinlerdir. Bu metinleri tetkik alanı olarak seçmiş olan bilim dalı Hadis İlmi'dir.Ülkemiz gibi belli bir süredir hızlı bir sosyolojik ve kültürel değişimi yaşayan coğrafyada Hadis ilmi alanında gerçekleştirilen bilimsel araştırmaların bu sosyolojik olguyu görmezden gelmesi, ona ilgisiz kalması ve hatta sosyolojinin yöntemlerinden yararlanmaması düşünülemezdi. Bilimsel disiplinlerarası yardımlaşma bu alanda daha fazla ihmal edilemezdi.Biz, bu tespit ve düşüncelerle yüksek lisans tez konumuzu "İstanbul'da Hadis/Sünnet Kültürü Araştırmaları; Eyüp İlçesi Örneği" diye belirledik ve anket yöntemiyle böyle bir çalışmayı gerçekleştirme yoluna gittik. Çalışmamız bu çerçevesiyle Hadis Anabilim Dalı'nda bir ilkti; dolayısiyle de ilk olmanın olumlu/olumsuz tüm özellik ve koşullarını taşıması pek tabiîdirBir anlamda belli bir esareti de temsil eden bu çalışmayı giriş ve iki bölüm olarak planladık. Girişte, araştırmanın konusu,amacı, sınırları ve yöntemi'ni işledik. Birinci Bölümde, "Hadis İlminde Sosyo-Kültürel Değişim Araştırmaları İhtiyacı"nı ve kültür değişmeleri olgusu karşısında Eyüp İlçesinin durumunu belirlemeye çalıştık. İkinci Bölüm'de ise, "Eyüp İlçesi'nde Hadis/Sünnet Kültürü (Anket ve Değerlendirme) başlığıyle durumu tespite gayret ettik.Aynı bölümün son kısmında karşılaştırmalı tablolarla bazı bulguların karşılıklı etkişemini göstermeye çalıştıABSTRACTWhat is dominant in ismamic sacieties beliefs and daily lives are thı Haly Book and sunnah. Haly Book contstitutes the saciety with its principles while sunnah with practices of the principles.Islamic studies are interested in haw this canshtution works or how is essentially must work within itself, as islam is a rligion of life Religion proves its existance with the practices. From this pint of view, religion is tatally a saciologcal phenamena.Sunneh, which means Islamic calture, directs the saciologic fact in Islamic sacieties. It's not an exaggration tu perceive the sign of the islam, as the contribution of sunnah to the saciety.The root of sunnah is the haditsh which are wnitten texts with pecular form. Hadith studies investigates than texts.In a geography like our country in which a rapid saciolagic and cultural changes have taken place for a while, there wauld certainly no room for ignorance and indifference of the scientific reseanches in the field of Hadith studies. Moreover, inevitably they made use of even saciolagical methods. Therefore they could have not neglected the scientific interdicipline chanty in this field.Thus, under the influence of these thaughts and approaches, we determined our master thesis subject as the "Hadith, Sunnah Cultural researches in Istanbul and Eyup district" and we fulfilled the study with the fuestionare tethod. From this point, our study is pioneer in Hadith ANABİLİM DALI (major study bnanch). Therefore it is natural that it invalves bath fasitive and negative sides of being a pioneer.We planned this study which represeents a certain courage as an intraduction and two parts in the intnacluction, we analysized the subjec, aim, boundanies and methods of the reseorch. In the first chapter, we try to determine "The Necessity of sacia-cultural transformation researches in the Hadith Study" and the situation under the title of Hadith and Sunnah rulture (questionare and evaluction) we tried to show mutual interaction of some findin with the comperative table in the last part of the same section.We attached the questionary questions to the and of the study

İstanbul’ da hadis/sünnet kültürü araştırmaları

TEZ İ İslâm toplumlarını gerek derûnî (inanç) gerekse günlük yaşantı(amel) yönünden dokuyan ve donatan Kitap-Sünnet ikilisidir. Birincisi(Kitap) ilke, ikincisi (Sünnet) uygulama ağırlıklı olarak toplumu inşa eder. İslâmî ilimler, söz konusu yapılanmanın kendi alanlarında nasıl cereyan ettiği, etmesi gerektiği ile ilgilidir. Zira İslâm hayat dinidir. Din ise, amel/uygulama ile toplumsal varlığını ispat ve ızhar eder. Bu açıdan bakıldığında din, tam anlamıyla sosyolojik bir fenomen/varlık ve gerçektir. İslâm toplumlarındaki sosyolojik olguları, İslâm kültürü emek olan Sünnet yönlendiregelmiştir. İslâm'ın bir toplumdaki izlerini, aynı zamanda Sünnet'in topluma kazandırdıkları olarak algılamak asla yanlış ya da abartı değildir. Köken olarak Hz. Peygamber'in mirası demek olan Sünnet'i, bize taşıyan ve tanıtan ise Hadis dediğimiz, belli forma sahip yazılı metinlerdir. Bu metinleri tetkik alanı olarak seçmiş olan bilim dalı Hadis İlmi'dir. Ülkemiz gibi belli bir süredir hızlı bir sosyolojik ve kültürel değişimi yaşayan coğrafyada Hadis ilmi alanında gerçekleştirilen bilimsel araştırmaların bu sosyolojik olguyu görmezden gelmesi, ona ilgisiz kalması ve hatta sosyolojinin yöntemlerinden yararlanmaması düşünülemezdi. Bilimsel disiplinlerarası yardımlaşma bu alanda daha fazla ihmal edilemezdi. Biz, bu tespit ve düşüncelerle yüksek lisans tez konumuzu "İstanbul'da Hadis/Sünnet Kültürü Araştırmaları; Eyüp İlçesi Örneği" diye belirledik ve anket yöntemiyle böyle bir çalışmayı gerçekleştirme yoluna gittik. Çalışmamız bu çerçevesiyle Hadis Anabilim Dalı'nda bir ilkti; dolayısiyle de ilk olmanın olumlu/olumsuz tüm özellik ve koşullarını taşıması pek tabiîdir Bir anlamda belli bir esareti de temsil eden bu çalışmayı giriş ve iki bölüm olarak planladık. Girişte, araştırmanın konusu,amacı, sınırları ve yöntemi'ni işledik. Birinci Bölümde, "Hadis İlminde Sosyo-Kültürel Değişim Araştırmaları İhtiyacı"nı ve kültür değişmeleri olgusu karşısında Eyüp İlçesinin durumunu belirlemeye çalıştık. İkinci Bölüm'de ise, "Eyüp İlçesi'nde Hadis/Sünnet Kültürü (Anket ve Değerlendirme) başlığıyle durumu tespite gayret ettik.Aynı bölümün son kısmında karşılaştırmalı tablolarla bazı bulguların karşılıklı etkişemini göstermeye çalıştı ABSTRACT What is dominant in ismamic sacieties beliefs and daily lives are thı Haly Book and sunnah. Haly Book contstitutes the saciety with its principles while sunnah with practices of the principles. Islamic studies are interested in haw this canshtution works or how is essentially must work within itself, as islam is a rligion of life Religion proves its existance with the practices. From this pint of view, religion is tatally a saciologcal phenamena. Sunneh, which means Islamic calture, directs the saciologic fact in Islamic sacieties. It's not an exaggration tu perceive the sign of the islam, as the contribution of sunnah to the saciety. The root of sunnah is the haditsh which are wnitten texts with pecular form. Hadith studies investigates than texts. In a geography like our country in which a rapid saciolagic and cultural changes have taken place for a while, there wauld certainly no room for ignorance and indifference of the scientific reseanches in the field of Hadith studies. Moreover, inevitably they made use of even saciolagical methods. Therefore they could have not neglected the scientific interdicipline chanty in this field. Thus, under the influence of these thaughts and approaches, we determined our master thesis subject as the "Hadith, Sunnah Cultural researches in Istanbul and Eyup district" and we fulfilled the study with the fuestionare tethod. From this point, our study is pioneer in Hadith ANABİLİM DALI (major study bnanch). Therefore it is natural that it invalves bath fasitive and negative sides of being a pioneer. We planned this study which represeents a certain courage as an intraduction and two parts in the intnacluction, we analysized the subjec, aim, boundanies and methods of the reseorch. In the first chapter, we try to determine "The Necessity of sacia-cultural transformation researches in the Hadith Study" and the situation under the title of Hadith and Sunnah rulture (questionare and evaluction) we tried to show mutual interaction of some findin with the comperative table in the last part of the same section. We attached the questionary questions to the and of the study

Effect of the addition of different spices on some characteristics of boza during stora

The purpose of this study is to investigate the effect of cinnamon, sage, lemon and clove on some properties of boza during storage. Crude boza s with spices was fermented for 1 day, and they were stored in the refrigerator for 5 days (the end of fermentation was the first day of storage). Both a decrease in the amount of total sugar (%), pH and viscosity, and a steady increase in ethyl alcohol (%) and acidity (%) values of all boza were observed during storage. Properties in lemon boza changed most. The highest reduction of total mezophilic aerobic bacteria and lacticacid bacteria counts was obtained in clove boza and sage boza, respectively. However, the highest reduction of yeast count was detected in clove, cinnamon and sage boza. In this study, coliform bacteria, mould and Staphylococcus aureus were not found. According to the sensory analysis, on the first day of storage, the highest score was in lemon boza in terms of appearance, in cinnamon boza in terms of flavors and in sage boza in terms of consistency. On the fourth day, the highest score was in plain boza in terms of appearance, in cinnamon boza in terms of flavor sand consistency. There was a positive impact of adding spices on the shelf life and aroma of boza. Modifications are not enough in boza studies. Therefore, this study is important in terms of contributing to studies in this direction. © 2014, National Centre for Agrarian Sciences. All rights reserved

The effect of the Turkish bath on women’s vital signs and oxygen saturation

531-534The purpose of this study was to investigate the effect of bathing in the Turkish bath, which is a source of high temperature and moisture, on Turkish women’s vital signs and oxygen saturation. The quantitative study was conducted on 275 women using the Turkish bath. The women’s blood pressure, pulse and respiratory rate, body temperature and oxygen saturation were measured before and after using the Turkish bath. The difference between vital signs and oxygen saturation before and after bathing was found to be statistically significant. It was determined that while mean blood pressures and mean oxygen saturation of women participants decreased after bathing, their mean pulse rate, mean breathing rate and mean body temperature increased after bathing. Nurses should advise taking precautions against risks that might develop as a result of using the Turkish bath