Non-Valvuler Atriyal Fibrilasyonu Olan Hastalarda Kanama Risk Sınıflandırılmasında Platelet-Lenfosit Oranının Yeni Kullanımları: Pilot Çalışma

Objective: The primary aim of this study was to investigate the role of platelet-lymphocyte ratio (PLR) to predict bleeding risk in nonvalvular atrial fibrillation (NVAF). Secondary aim was to determine the possible relation between PLR and thromboembolic and bleeding risk scores. Tertiary aim was to evaluate the predictive value of PLR for the patients in the therapeutic international normalized ratio (INR) range. Method: PLR was calculated from the complete blood count of 228 patients who were under warfarin management for NVAF. The patients were called and it was questioned whether they had experienced the bleeding event within six months after measurement of the PLR values. Correspondence/Yazışma Adresi: Kahraman Cosansu, Deparment of Cardiology, Sakarya University, Education and Research Hospital Sakarya, Turkey, 54100 e-mail: [email protected] DOI: 10.5798/dicletip.705814 Results: Bleeding event was observed in 48 patients after the PLR was calculated. It was found significantly correlation between PLR and CHA2DVAS2C (p165,9 was determined significant indicator for bleeding (p 165,9 değeri kanama için önemli bir gösterge olarak belirlendi (p <0.001) ve 12 kattan fazla kanama riski olduğunu gösterdi (12.27, [5.74-26.21]). Sonuç: Bu çalışmanın sonuçları PLR'nin kanama riskini saptamak için yararlı bir parametre olabileceğini göstermektedir. Bildiğimiz kadarıyla, bu PLR'nin hem CHA2DS2-VASc hem de HAS-BLED risk skorları ile korelasyonunu gösteren ilk çalışmadır. PLR ayrıca terapötik INR aralığındaki hastaları da öngörebilir

Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: a novel finding

Background: Apelin is a novel endogenous peptide with inotropic and vasodilatory properties. Aim: To investigate the role of apelin in the prognosis of acute coronary syndromes (ACS) and to assess the relationship between apelin and other diagnostic and prognostic markers. Methods: Seventy-six patients with ACS (mean age 62.1 ± 10 years) were evaluated in terms of their plasma apelin-36 concentrations, ejection fraction (EF), high sensitivity C-reactive protein (hsCRP), creatine kinase (CK), CK-MB and troponin I levels. The study group consisted of 35 ST elevation myocardial infarction (STEMI) and 41 non-ST elevation (NSTE) ACS patients. Patients were followed up for one year for cardiovascular outcomes. Results: There was no significant relationship between apelin and TIMI, GRACE, GENSINI scores, hsCRP and EF in STEMI and NSTE-ACS groups (p > 0.05). Apelin showed positive correlations with CK, CK-MB and troponin I in patients with NSTE-ACS, but a negative correlation in patients with STEMI (p < 0.05). There were no statistically significant differences between patients reaching the composite end point at one year with regard to apelin levels. Conclusions: Apelin was positively correlated with cardiac biomarkers in patients with NSTE-ACS but negatively correlated in patients with STEMI. In STEMI, generally larger amounts of myocardial cells are subjected to infarction compared to NSTE-ACS, which may explain why apelin levels decrease with increasing CK, CK-MB and troponin levels in STEMI patients. Copyright © Polskie Towarzystwo Kardiologiczne

Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: A novel finding

Background: Apelin is a novel endogenous peptide with inotropic and vasodilatory properties. Aim: To investigate the role of apelin in the prognosis of acute coronary syndromes (ACS) and to assess the relationship between apelin and other diagnostic and prognostic markers. Methods: Seventy-six patients with ACS (mean age 62.1 ± 10 years) were evaluated in terms of their plasma apelin-36 concentrations, ejection fraction (EF), high sensitivity C-reactive protein (hsCRP), creatine kinase (CK), CK-MB and troponin I levels. The study group consisted of 35 ST elevation myocardial infarction (STEMI) and 41 non-ST elevation (NSTE) ACS patients. Patients were followed up for one year for cardiovascular outcomes. Results: There was no significant relationship between apelin and TIMI, GRACE, GENSINI scores, hsCRP and EF in STEMI and NSTE-ACS groups (p > 0.05). Apelin showed positive correlations with CK, CK-MB and troponin I in patients with NSTE-ACS, but a negative correlation in patients with STEMI (p < 0.05). There were no statistically significant differences between patients reaching the composite end point at one year with regard to apelin levels. Conclusions: Apelin was positively correlated with cardiac biomarkers in patients with NSTE-ACS but negatively correlated in patients with STEMI. In STEMI, generally larger amounts of myocardial cells are subjected to infarction compared to NSTE-ACS, which may explain why apelin levels decrease with increasing CK, CK-MB and troponin levels in STEMI patients. Copyright © Polskie Towarzystwo Kardiologiczne