Typologie de L’insertion Professionnelle des Personnes Diplomees de L’Universite

The objectives of this paper are a) to delimit the notion of vocational integration, b) to formulate a vocational integration typology for university graduates, taking into account both the «traditional» method of integration (integration at the end of bachelor's degree and rapid stabilization on the labour market), and other methods where integration occurs in phases and stabilization on the labour market follows later, c) to demonstrate the empirical relevance of the typology. The data analysis was based on a data bank on the progression through school and labour market entry of all persons who received undergraduate degrees from Université Laval in 1986. This analysis was not conducted in order to generalize the results for the Quebec population as a whole but rather to demonstrate the typology's relevance and empirical usefulness.Les objectifs de l'article sont a) de circonscrire la notion d'insertion professionnelle, b) d'élaborer une typologie de l'insertion professionnelle des personnes diplômées universitaires qui tienne compte à la fois des modes d'insertion dits «traditionnels» (insertion au terme des études de premier cycle seulement et stabilisation rapide sur le marché de l'emploi) et d'autres modes d'insertion impliquant un échelonnement de l'insertion dans le temps et une stabilisation plus tardive et c) de démontrer la pertinence de cette typologie au plan empirique. L'analyse des données a été effectuée à partir de la banque de données sur les cheminements scolaires et l'entrée sur le marché du travail des personnes diplômées du premier cycle de l'Université Laval en 1986. L'analyse n'a pas été conduite à des fins de généralisation des résultats à l'ensemble du Québec mais dans le but de démontrer la pertinence théorique de la typologie et son utilité au plan empiriqu

Social Anxiety and Non-Medical Prescription Stimulant Use Among College Students

Current evidence suggests that non-medical prescription stimulant (NMPS) use is on the rise, particularly among college students. Identifying individuals at risk for regular and problematic use is a critical step towards the development of effective intervention efforts. A growing body of work has noted that individuals with elevated levels of social anxiety (SA) or social anxiety disorder are at an enhanced risk for developing substance use problems, including NMPS use disorder. Despite the relevance of SA and NMPS use among college students, no studies have attempted to examine subclinical SA or the relation between SA and NMPS use among college students specifically. Thus, the present study sought to extend this area by testing the relation of SA symptoms and NMPS use frequency among college students. A large online study of college students was conducted (N=1604) to identify 252 NMPS users (18-25 years; 68.3% female). A hierarchical linear regression was used to test the moderation of positive prescription stimulant expectancies on SA symptoms in predicting past year NMPS use frequency. A subsample of 15 participants was also brought into the lab to assess subjective (State Anxiety) and physiological (salivary cortisol) responding to a social stressor task. Overall, the current study did not provide evidence that SA, via retrospective self-report or real-time responding was related to past year NMPS use frequency. Additional research is needed to resolve the discrepancies between the present findings and prior work

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

L'insertion professionnelle des finissantes et des finissants du Conservatoire de musique du Québec

Although the Conservatoire de musique du Québec (CMQ) has existed for half a century, to date very little information has been compiled on the origins of its students or on how its graduates have fared. We have thus produced a data bank on this clientele, covering students who graduated from the CMQ between 1988 and 1991, and used it to determine how their careers have progressed since this time. In order to better comprehend the factors influencing the students' integration into the labour market, which is the aim of the article, we have taken into account gender, family background, age at which musical training began, levels of schooling completed, main area of study, and the grades obtained from the institution. It would be interesting to determine whether a large proportion of these individuals pursued their musical training after graduating from the CMQ. We do know, however, that over 80% of employed CMQ graduates found jobs in a field related to their studies.Bien que le Conservatoire de musique du Québec (CMQ) ait franchi le demi-siècle d'histoire, peu de renseignements concernant les origines et les devenirs de ses finissantes et ses finissants ont été produits jusqu'à ce jour. Ainsi, nous avons constitué une banque de données portant sur cette clientèle, à partir des promotions des années 1988 à 1991, et c'est à l'aide de ces données que nous avons cherché à comprendre ce qu'il advient des individus qui ont complété une formation au CMQ. Afin de mieux saisir les facteurs d'influence de l'insertion professionnelle de cette clientèle - sujet au centre de cet article -, nous avons tenu compte du sexe, de l'origine familiale, de l'âge du début des apprentissages musicaux, de l'ordre d'enseignement complété, de la discipline principale étudiée ainsi que de la note décernée par l'Institution. Il serait intéressant de vérifier avec attention si une proportion importante de ces individus poursuivent leur formation musicale après le CMQ. Toutefois, nous savons que parmi celles et ceux qui occupent des emplois à la suite de ces études, plus de 80% le font dans des domaines correspondant à leur formation musicale

Creation and implementation of SAMPRO™: A school-based asthma management program

Clinicians who care for children with asthma have an obligation to coordinate asthma care with the schools. Aside from routine clinical care of asthmatic children, providers must educate the family and child about the need for an asthma treatment plan in school and support the school nurse meeting the needs of the student requiring school-based asthma care. The following article was developed by multiple stakeholders to address this need. It describes the 4 components of the School-based Asthma Management Program (SAMPRO™). SAMPRO™ details elements necessary for the education of children, families, clinicians, and school-based personnel based on a “circle of support” that would enhance multidirectional communication and promote better care for children with asthma within the school setting

Indirect Associations of Anxiety Sensitivity with Tobacco, Alcohol, and Other Drug Use Problems Through Emotional Disorder Symptoms in Adolescents.

Theoretically, anxiety sensitivity-fear of anxiety symptoms-enhances perception of and emotional reactivity to autonomic arousal and mental distress, thereby increasing negative affect and motivation to use substances for negative reinforcement. Because no prior study of adolescents has tested if anxiety sensitivity is indirectly associated with substance use problems through symptoms of emotional disorders (i.e., disorders involving high levels of negative affect), the current cross-sectional study examined this theoretical pathway. Participants included ninth-grade students from 10 different high schools in the Los Angeles metropolitan area (N = 3005; 54.3% female). Self-report measures of anxiety sensitivity, emotional disorder symptoms, tobacco dependence, and alcohol and other drug problems were administered. Controlling for sex, race/ethnicity, parental education, school, and impulsiveness, we tested the associations of anxiety sensitivity with tobacco, alcohol, and other drug use problems as well as the indirect effects of anxiety sensitivity on each domain of substance use problems through emotional disorder symptoms. Anxiety sensitivity was associated with more severe tobacco dependence and greater alcohol problems and other drug problems, and anxiety sensitivity further was indirectly associated with all three domains of substance use problems through emotional disorder symptoms. Current findings suggest that adolescents high in anxiety sensitivity tend to experience emotional disorder symptoms, which may increase risk for substance use problems. Interventions that target anxiety sensitivity and enhance negative-affect coping skills may assist in preventing and reducing adolescent substance use problems

LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated 1 ovarian cancers

Objective: Endometrioid (ENOC) and clear cell ovarian carcinoma (CCOC) share a common precursor lesion, endometriosis, hence the designation endometriosis associated ovarian cancers (EAOC). Long interspersed nuclear element 1 (LINE-1 or L1), is a family of mobile genetic elements activated in many cancers capable of moving neighboring DNA through 3’ transductions. Here we investigated the involvement of specific L1-mediated transductions in EAOCs. Methods: Through whole genome sequencing, we identified active L1-mediated transductions originating within the TTC28 gene in 34% (10/29) of ENOC and 31% (11/35) of CCOC cases. We used PCR and capillary sequencing to assess the presence of specific TTC28-L1 transductions in formalin-fixed paraffin-embedded (FFPE) blocks from six different anatomical sites (five tumors and one normal control) for four ENOC and three CCOC cases, and compared the results to the presence of single nucleotide variations (SNVs)/frame shift (fs) mutations detected using multiplex PCR and next generation sequencing. Results: TTC28-L1 mediated transductions were identified in at least three tumor samplings in all cases, and were present in all five tumor samplings in 5/7 (71%) cases. In these cases, KRAS, PIK3CA, CTNNB1, ARID1A, and PTEN mutations were found across all tumor sites whilst other selected SNV/fs mutations of unknown significance were present at varying allelic frequencies. Conclusion: The TTC28-L1 transductions along with classical driver mutations were near ubiquitous across the tumors, suggesting that L1 activation likely occurred early in the development of EAOCs. TTC28-L1 transductions could potentially be used to determine clonal relationships and to track ovarian cancer progression.Medicine, Faculty ofNon UBCObstetrics and Gynaecology, Department ofPathology and Laboratory Medicine, Department ofReviewedFacultyResearche

Distinct cellular origins for endometrioid and clear cell cancers

Endometrial epithelium is the presumed tissue of origin for both eutopic and endometriosis-derived clear cell and endometrioid carcinomas. We had previously hypothesized that the morphological, biological and clinical differences between these cancers are due to subtype-restricted underlying mutations. Although some mutations and genomic landscape features are more likely to be found in one of these histotypes, we were not able to identify a single class of mutations that was exclusively present in one histotype and not the other. This lack of genomic differences led us to an alternative hypothesis that these cancers arise from distinct cells of origin within endometrial tissue, and it is the cellular context that accounts for their differences. In a proteomics screen, we have identified CTH as a marker for clear cell carcinoma differentiation, as it is expressed at high levels in clear cell carcinomas of the ovary and endometrium. We analyzed normal Müllerian tissues and found CTH was expressed in ciliated cells of endometrium (both eutopic endometrium and endometriosis) and fallopian tube. We have since determined that other ciliated cell markers are expressed in clear cell carcinomas whereas endometrial secretory cell markers are expressed in endometrioid carcinomas. To determine whether the ciliated endometrial cells are uterine derived we developed a 3D organoid culture system, which reliably produced both ciliated and secretory cells. Clear cell carcinoma is an IL-6 driven tumour and lineage experiments on bronchial epithelium have shown that IL-6 is an essential pathway in maintaining the population of ciliated cells. Taken together we hypothesize that endometrioid carcinomas are derived from cells of secretory cell lineage whereas clear cell carcinomas are derived from cells of endometrial origin that share features with a ciliated cell lineage.Medicine, Faculty ofNon UBCObstetrics and Gynaecology, Department ofPathology and Laboratory Medicine, Department ofUnreviewedFacultyPostdoctora