Estimating Preferences For Water Quality Improvements Using A Citizens' Jury And Choice Modelling: A Case Study On The Bremer River Catchment, South East Queensland

This paper describes a study undertaken on the Bremer River catchment in south east Queensland. The study informed members of the community about water quality issues in the catchment through a citizens' jury and then solicited their opinion about whether more resources should be devoted towards improving water quality and how much they thought the community should pay. A choice modelling survey was conducted prior to and at the conclusion of the citizens' jury. The jury accepted that more resources should be devoted to improving water quality in the catchment, making a number of pertinent recommendations about how and where additional resources should be directed. In addition, the jury indicated that, in terms of willingness to pay, riparian vegetation was an important ecosystem attribute. Although the preliminary and final models derived for the choice modelling exercise indicate that the models were not equivalent, there was no statistical difference in the implicit prices between the two models. Nevertheless, the confidence interval of the implicit prices narrowed following the provision of information in the citizens' jury and there was an improvement in the statistical reliability of the model

Modal dependent type theory and dependent right adjoints

In recent years we have seen several new models of dependent type theory extended with some form of modal necessity operator, including nominal type theory, guarded and clocked type theory, and spatial and cohesive type theory. In this paper we study modal dependent type theory: dependent type theory with an operator satisfying (a dependent version of) the K-axiom of modal logic. We investigate both semantics and syntax. For the semantics, we introduce categories with families with a dependent right adjoint (CwDRA) and show that the examples above can be presented as such. Indeed, we show that any finite limit category with an adjunction of endofunctors gives rise to a CwDRA via the local universe construction. For the syntax, we introduce a dependently typed extension of Fitch-style modal lambda-calculus, show that it can be interpreted in any CwDRA, and build a term model. We extend the syntax and semantics with universes

On site 2 : Bruce Armstrong, Paul Boston, Alison Clouston, Susan Norrie

On site 2 : Bruce Armstrong, Paul Boston, Alison Clouston, Susan Norrie Catalogue of exhibition held at the Centre for the Arts Gallery, Oct. 17-31, 1986. Works by Bruce Armstrong, Paul Boston, Alison Clouston, Susan Norri

Two Asymmetries between Clitic Left and Clitic Right Dislocation in Bulgarian

The paper discusses some subtle points of the syntax of clitic left dislocation and clitic right dislocation in Bulgarian

Genome-Wide Copy Number Analysis in Esophageal Adenocarcinoma Using High-Density Single-Nucleotide Polymorphism Arrays

We applied whole-genome single-nucleotide polymorphism arrays to define a comprehensive genetic profile of 23 esophageal adenocarcinoma (EAC) primary tumor biopsies based on loss of heterozygosity (LOH) and DNA copy number changes. Alterations were common, averaging 97 (range, 23-208) per tumor. LOH and gains averaged 33 (range, 3-83) and 31 (range, 11-73) per tumor, respectively. Copy neutral LOH events averaged 27 (range, 7-57) per EAC. We noted 126 homozygous deletions (HD) across the EAC panel (range, 0-11 in individual tumors). Frequent HDs within FHIT (17 of 23), WWOX (8 of 23), and DMD (6 of 23) suggest a role for common fragile sites or genomic instability in EAC etiology. HDs were also noted for known tumor suppressor genes (TSG), including CDKN2A, CDKN2B, SMAD4, and GALR1, and identified PDE4D and MGC48628 as potentially novel TSGs. All tumors showed LOH for most of chromosome 17p, suggesting that TSGs other than TP53 may be targeted. Frequent gains were noted around MYC (13 of 23), BCL9 (12 of 23), CTAGE1 (14 of 23), and ZNF217 (12 of 23). Thus, we have confirmed previous reports indicating frequent changes to FHIT, CDKN2A, TP53, and MYC in EAC and identified additional genes of interest. Meta-analysis of previous genome-wide EAC studies together with the data presented here highlighted consistent regions of gain on 8q, 18q, and 20q and multiple LOH regions on 4q, 5q, 17p, and 18q, suggesting that more than one gene may be targeted on each of these chromosome arms. The focal gains and deletions documented here are a step toward identifying the key genes involved in EAC development

The variability of the sediment plume and ocean circulation features of the Nass River Estuary, British Columbia

The Nass River discharges into Nass Bay and Iceberg Bay, which are adjoining tidal inlets located within the northern inland waters of British Columbia, Canada. After the Skeena River, the Nass River is the second longest river within northern British Columbia, which discharges directly into Canadian waters of the Pacific Ocean. It is also supports one of the most productive salmon fisheries in northern British Columbia. The Nass River discharges into the eastern end of Nass Bay. Nass Bay, in turn feeds into Portland Canal and the fresh surface waters then flows westward to the Pacific Ocean via Dixon Entrance. The tides in Northern British Columbia are very large with a tidal height range of just over 7 m. Nass Bay is a shallow inlet of less than 10 km in length with typical water depths of than 10 m or less. The existing knowledge of oceanographic processes in Nass and Iceberg Bays was rudimentary until three years ago, when the first modern oceanographic measurements were obtained. In this study, the seasonal and tidal variability of the lateral extent of the Nass River surface plume is mapped from analyses of Landsat satellite data spanning the period from 2008 to 2015. A high resolution coupled three dimensional (3D) hydrodynamic model was developed and implemented, within the widely used and accepted Delft3D modeling framework, which was forced and validated using recent 2013-2016 in-situ oceanographic measurements. The combined satellite and numerical modeling methods are used to study the physical oceanographic and sediment transport regime of Nass and Iceberg Bays and the adjoining waters of Portland Inlet and Observatory Inlet. The ocean circulation of Nass and Iceberg Bays was found to be dominated by tidal currents, and by the highly seasonal and variable Nass River freshwater discharges. Complex lateral spatial patterns in the tidal currents occur due to the opening of the southwestern side of Nass Bay onto the deeper adjoining waters of Iceberg Bay. Surface winds are limited to a secondary role in the circulation variability. The sediment dynamics of the Nass Bay system features a very prominent surface sediment plume present from the time of freshet in mid-spring through to large rainfall runoff events in the fall. The time-varying turbidity distribution and transport paths of the Nass River sediment discharges in the study area were characterized using the model results combined with an analysis of several high-resolution multi-year Landsat satellite data sets

Coordinated analysis of age, sex, and education effects on change in MMSE scores

Objectives. We describe and compare the expected performance trajectories of older adults on the Mini-Mental Status Examination (MMSE) across six independent studies from four countries in the context of a collaborative network of longitudinal studies of aging. A coordinated analysis approach is used to compare patterns of change conditional on sample composition differences related to age, sex, and education. Such coordination accelerates evaluation of particular hypotheses. In particular, we focus on the effect of educational attainment on cognitive decline.Method. Regular and Tobit mixed models were fit to MMSE scores from each study separately. The effects of age, sex, and education were examined based on more than one centering point.Results. Findings were relatively consistent across studies. On average, MMSE scores were lower for older individuals and declined over time. Education predicted MMSE score, but, with two exceptions, was not associated with decline in MMSE over time.Conclusion. A straightforward association between educational attainment and rate of cognitive decline was not supported. Thoughtful consideration is needed when synthesizing evidence across studies, as methodologies adopted and sample characteristics, such as educational attainment, invariably differ. © 2012 The Author

InForm software: A semi-Automated research tool to identify presumptive human hepatic progenitor cells, and other histological features of pathological significance

Hepatic progenitor cells (HPCs) play an important regenerative role in acute and chronic liver pathologies. Liver disease research often necessitates the grading of disease severity, and pathologists' reports are the current gold-standard for assessment. However, it is often impractical to recruit pathologists in large cohort studies. In this study we utilise PerkinElmer's "InForm" software package to semi-Automate the scoring of patient liver biopsies, and compare outputs to a pathologist's assessment. We examined a cohort of eleven acute hepatitis samples and three non-Alcoholic fatty liver disease (NAFLD) samples, stained with HPC markers (GCTM-5 and Pan Cytokeratin), an inflammatory marker (CD45), Sirius Red to detect collagen and haematoxylin/eosin for general histology. InForm was configured to identify presumptive HPCs, CD45 +ve inflammatory cells, areas of necrosis, fat and collagen deposition (p < 0.0001). Hepatitis samples were then evaluated both by a pathologist using the Ishak-Knodell scoring system, and by InForm through customised algorithms. Necroinflammation as evaluated by a pathologist, correlated with InForm outputs (r 2 = 0.8192, p < 0.05). This study demonstrates that the InForm software package provides a useful tool for liver disease research, allowing rapid, and objective quantification of the presumptive HPCs and identifies histological features that assist with assessing liver disease severity, and potentially can facilitate diagnosis

Whole genome expression array profiling highlights differences in mucosal defense genes in Barrett's esophagus and esophageal adenocarcinoma

Extent: 15p.Esophageal adenocarcinoma (EAC) has become a major concern in Western countries due to rapid rises in incidence coupled with very poor survival rates. One of the key risk factors for the development of this cancer is the presence of Barrett's esophagus (BE), which is believed to form in response to repeated gastro-esophageal reflux. In this study we performed comparative, genome-wide expression profiling (using Illumina whole-genome Beadarrays) on total RNA extracted from esophageal biopsy tissues from individuals with EAC, BE (in the absence of EAC) and those with normal squamous epithelium. We combined these data with publically accessible raw data from three similar studies to investigate key gene and ontology differences between these three tissue states. The results support the deduction that BE is a tissue with enhanced glycoprotein synthesis machinery (DPP4, ATP2A3, AGR2) designed to provide strong mucosal defenses aimed at resisting gastro-esophageal reflux. EAC exhibits the enhanced extracellular matrix remodeling (collagens, IGFBP7, PLAU) effects expected in an aggressive form of cancer, as well as evidence of reduced expression of genes associated with mucosal (MUC6, CA2, TFF1) and xenobiotic (AKR1C2, AKR1B10) defenses. When our results are compared to previous whole-genome expression profiling studies keratin, mucin, annexin and trefoil factor gene groups are the most frequently represented differentially expressed gene families. Eleven genes identified here are also represented in at least 3 other profiling studies. We used these genes to discriminate between squamous epithelium, BE and EAC within the two largest cohorts using a support vector machine leave one out cross validation (LOOCV) analysis. While this method was satisfactory for discriminating squamous epithelium and BE, it demonstrates the need for more detailed investigations into profiling changes between BE and EAC.Derek J. Nancarrow, Andrew D. Clouston, B. Mark Smithers, David C. Gotley, Paul A. Drew, David I. Watson, Sonika Tyagi, Nicholas K. Hayward, David C. Whiteman, for the Australian Cancer Study and the Study of Digestive Healt