Spatiotemporal Coordination Supports a Sense of Commitment in Human-Robot Interaction

In the current study, we presented participants with videos in which a humanoid robot (iCub) and a human agent were tidying up by moving toys from a table into a container. In the High Coordination condition, the two agents worked together in a coordinated manner, with the human picking up the toys and passing them to the robot. In the Low Coordination condition, they worked in parallel without coordinating. Participants were asked to imagine themselves in the position of the human agent and to respond to a battery of questions to probe the extent to which they felt committed to the joint action. While we did not observe a main effect of our coordination manipulation, the results do reveal that participants who perceived a higher degree of coordination also indicated a greater sense of commitment to the joint action. Moreover, the results show that participants’ sensitivity to the coordination manipulation was contingent on their prior attitudes towards the robot: participants in the High Coordination condition reported a greater sense of commitment than participants in the Low Coordination condition, except among those participants who were a priori least inclined to experience a close sense of relationship with the robot

Protein tyrosine kinases and protein tyrosine phosphatases are involved in abscisic acid-dependent processes in Arabidopsis seeds and suspension cells.

International audienceProtein tyrosine (Tyr) phosphorylation plays a central role in many signaling pathways leading to cell growth and differentiation in animals. Tyr phosphorylated proteins have been detected in higher plants, and the roles of protein Tyr phosphatases and protein Tyr kinases in some physiological responses have been shown. We investigated the involvement of Tyr phosphorylation events in abscisic acid (ABA) signaling using a pharmacological approach. Phenylarsine oxide, a specific inhibitor of protein Tyr phosphatase activity, abolished the ABA-dependent accumulation of RAB18 (responsive to ABA 18) transcripts. Protein Tyr kinase inhibitors like genistein, tyrphostin A23, and erbstatin blocked the RAB18 expression induced by ABA in Arabidopsis (Arabidopsis thaliana). Stomatal closure induced by ABA was also inhibited by phenylarsine oxide and genistein. We studied the changes in the Tyr phosphorylation levels of proteins in Arabidopsis seeds after ABA treatment. Proteins were separated by two-dimensional gel electrophoresis, and those phosphorylated on Tyr residues were detected using an anti-phosphotyrosine antibody by western blot. Changes were detected in the Tyr phosphorylation levels of 19 proteins after ABA treatment. Genistein inhibited the ABA-dependent Tyr phosphorylation of proteins. The 19 proteins were analyzed by matrix-assisted laser-desorption ionization time-of-flight/time-of-flight mass spectrometry. Among the proteins identified were storage proteins like cruciferins, enzymes involved in the mobilization of lipid reserves like aconitase, enolase, aldolase, and a lipoprotein, and enzymes necessary for seedling development like the large subunit of Rubisco. Additionally, the identification of three putative signaling proteins, a peptidyl-prolyl isomerase, an RNA-binding protein, and a small ubiquitin-like modifier-conjugating enzyme, enlightens how Tyr phosphorylation might regulate ABA transduction pathways in plants

Interpretation of suspect head and neck fixations seen on PET/CT in lung cancer.

International audienceSmoking is the major risk factor for lung and head and neck cancer. The purpose of the present study was to determine the clinical impact of serendipitously revealed head and neck fixation on PET/CT in patients undergoing investigation for lung cancer. The reports from PET/CT studies for patients with lung cancer from September 2005 and April 2012 were retrospectively reviewed. Head and neck incidentaloma was interpreted as suggestive of second primary malignancy. These incidental findings were compared with the final diagnosis obtained from clinical and histological investigation. Five hundred and ninety-two patients were investigated on PET/CT for lung cancer in the study period. PET/CT-positive head and neck lesions suggestive of second primary malignancy were found in 65 (11%) patients. Nasoendoscopy was performed in 23 patients and biopsy in 10. In 4 patients (17.4% of those explored), a second primary malignant lesion was proved on histology: 2 squamous cell carcinomas (larynx and oral cavity), 1 undifferentiated carcinoma (parotid), and 1 osteosarcoma (mandible). At a median 13 months' follow-up, 3 of the 4 patients with a second primary had died from disease-related causes and 1 was free of recurrence. Metastases from lung adenocarcinoma were found in 2 patients (0.34%). PET/CT detected incidental head and neck malignant tumors in at least 0.68% of lung cancer patients, but in 6.4% of those with suspect head and neck fixation

High-efficiency air conditioning - Improving comfort and reducing impact on fuel consumption

International audienceDue to its widespread diffusion, cars A/C systems will face two challenges: a better evaluation of perceived thermal comfort and the reduction of the impact on fuel consumption. In summer and during an urban cycle, the A/C system can increase fuel consumption up to 70%. In view of future regulations and of environmental concern, actions are needed to reduce A/C impact. This paper describes the development of an innovative climate control system accomplished by Fiat Research Center on a B Class Car. Significant results can be achieved thanks to externally controlled variable displacement compressors and to the integration of several control systems