Alien Registration- Cliche, Philippe (Lewiston, Androscoggin County)

https://digitalmaine.com/alien_docs/29628/thumbnail.jp

Limits on the ultra-bright Fast Radio Burst population from the CHIME Pathfinder

We present results from a new incoherent-beam Fast Radio Burst (FRB) search on the Canadian Hydrogen Intensity Mapping Experiment (CHIME) Pathfinder. Its large instantaneous field of view (FoV) and relative thermal insensitivity allow us to probe the ultra-bright tail of the FRB distribution, and to test a recent claim that this distribution's slope, $\alpha\equiv-\frac{\partial \log N}{\partial \log S}$, is quite small. A 256-input incoherent beamformer was deployed on the CHIME Pathfinder for this purpose. If the FRB distribution were described by a single power-law with $\alpha=0.7$, we would expect an FRB detection every few days, making this the fastest survey on sky at present. We collected 1268 hours of data, amounting to one of the largest exposures of any FRB survey, with over 2.4\,$\times$\,10$^5$\,deg$^2$\,hrs. Having seen no bursts, we have constrained the rate of extremely bright events to $<\!13$\,sky$^{-1}$\,day$^{-1}$ above $\sim$\,220$\sqrt{(\tau/\rm ms)}$ Jy\,ms for $\tau$ between 1.3 and 100\,ms, at 400--800\,MHz. The non-detection also allows us to rule out $\alpha\lesssim0.9$ with 95$\%$ confidence, after marginalizing over uncertainties in the GBT rate at 700--900\,MHz, though we show that for a cosmological population and a large dynamic range in flux density, $\alpha$ is brightness-dependent. Since FRBs now extend to large enough distances that non-Euclidean effects are significant, there is still expected to be a dearth of faint events and relative excess of bright events. Nevertheless we have constrained the allowed number of ultra-intense FRBs. While this does not have significant implications for deeper, large-FoV surveys like full CHIME and APERTIF, it does have important consequences for other wide-field, small dish experiments

Alien Registration- Cliche, Philippe (Lewiston, Androscoggin County)

https://digitalmaine.com/alien_docs/29628/thumbnail.jp

Phenotyping the Responses to Systemic Corticosteroids in the Management of Asthma Attacks (PRISMA): protocol for an observational and translational pilot study

Abstract: Introduction Asthma and its associated exacerbation are heterogeneous. Although severe asthma attacks are systematically prescribed corticosteroids and often antibiotics, little is known about the variability of response to these therapies. Blood eosinophils and fractional exhaled nitric oxide (FeNO) are type 2 inflammation biomarkers that have established mechanistic, prognostic and theragnostic values in chronic asthma, but their utility in acute asthma is unclear. We speculate that the clinical and biological response to those treatments varies according to inflammometry and microbiological test results. Methods and analysis An observational longitudinal pilot study with multimodal clinical and translational assessments will be performed on 50 physician-diagnosed ≥12-year-old asthmatics presenting with an asthma attack and 12 healthy controls, including blood eosinophil count (venous and point-of-care (POC) capillary blood), FeNO and testing for airway infection (sputum cultures and POC nasopharyngeal swabs). People with asthma will be assessed on day 0 and after a 7-day corticosteroid course, with home monitoring performed in between. The primary analysis will be the change in the forced expiratory volume in 1 s according to type 2 inflammatory status (blood eosinophils ≥0.15×109 /L and/or FeNO ≥25 ppb) after treatment. Key secondary analyses will compare changes in symptom scores and the proportion of patients achieving a minimal clinically important difference. Exploratory analyses will assess the relationship between clinical, lung function, inflammatory and microbiome parameters; satisfaction plus reliability indices of POC tests; and sex– gender variability in treatment response. Ultimately, this pilot study will serve to plan a larger trial comparing the clinical and biological response to systemic corticosteroids according to inflammatory biomarkers, offering valuable guidance for more personalised therapeutic strategies in asthma attacks. Ethics and dissemination The protocol has been approved by the Research Ethics Committee of the CIUSSS de l'Estrie–CHUS, Sherbrooke, Quebec, Canada (#2023- 4687). Results will be communicated in an international meeting and submitted to a peer-reviewed journal

Phenotyping the Responses to Systemic Corticosteroids in the Management of Asthma Attacks (PRISMA): protocol for an observational and translational pilot study

Introduction Asthma and its associated exacerbation are heterogeneous. Although severe asthma attacks are systematically prescribed corticosteroids and often antibiotics, little is known about the variability of response to these therapies. Blood eosinophils and fractional exhaled nitric oxide (FeNO) are type 2 inflammation biomarkers that have established mechanistic, prognostic and theragnostic values in chronic asthma, but their utility in acute asthma is unclear. We speculate that the clinical and biological response to those treatments varies according to inflammometry and microbiological test results.Methods and analysis An observational longitudinal pilot study with multimodal clinical and translational assessments will be performed on 50 physician-diagnosed ≥12-year-old asthmatics presenting with an asthma attack and 12 healthy controls, including blood eosinophil count (venous and point-of-care (POC) capillary blood), FeNO and testing for airway infection (sputum cultures and POC nasopharyngeal swabs). People with asthma will be assessed on day 0 and after a 7-day corticosteroid course, with home monitoring performed in between. The primary analysis will be the change in the forced expiratory volume in 1 s according to type 2 inflammatory status (blood eosinophils ≥0.15×109/L and/or FeNO ≥25 ppb) after treatment. Key secondary analyses will compare changes in symptom scores and the proportion of patients achieving a minimal clinically important difference. Exploratory analyses will assess the relationship between clinical, lung function, inflammatory and microbiome parameters; satisfaction plus reliability indices of POC tests; and sex–gender variability in treatment response. Ultimately, this pilot study will serve to plan a larger trial comparing the clinical and biological response to systemic corticosteroids according to inflammatory biomarkers, offering valuable guidance for more personalised therapeutic strategies in asthma attacks.Ethics and dissemination The protocol has been approved by the Research Ethics Committee of the CIUSSS de l'Estrie–CHUS, Sherbrooke, Quebec, Canada (#2023-4687). Results will be communicated in an international meeting and submitted to a peer-reviewed journal.Trial registration number ClinicalTrials.gov Registry (NCT05870215)

Thermokinetic Modelling of High-Temperature Evolution of Primary Nb(C,N) in Austenite Applied to Recrystallization of 316Nb Austenitic Stainless Steel

International audienceThe size evolution of niobium carbonitrides Nb(C,N) and the evolution of the composition of an austenitic matrix in 316Nb stainless steel were simulated using DICTRA software. For the first time, the complete nine-element composition of steel was taken into account during isothermal and even anisothermal heat treatments. A reduced model was then proposed to optimize the calculation time for complex heat treatments. The change in the mean Nb content in austenite due to Nb(C,N) evolution during different heat treatments was studied. It qualitatively agrees with experimental data as obtained by electron probe microanalysis. Furthermore, the model was successfully applied to explain the effect of heat treatments on the recrystallization behavior of 316Nb steel during hot torsion tests. Moreover, the effect of the thermodynamic database and the number of alloying elements chosen was discussed. We showed that taking into account seven or even nine elements greatly improves the accuracy compared to usual simplified compositions. The proposed method can be useful in designing heat treatments promoting or conversely hindering recrystallization for a wide variety of Nb-bearing steels

Pour une histoire du risque

L’histoire du risque que propose ce livre déborde largement les notions de statistique, de calcul probabilitaire et de traitement assurantiel des dangers. Si, en effet, le risque a une histoire, le risque est aussi histoire, car il concerne le rapport des sociétés au temps. Tout rapport au risque tente, à partir de l’expérience passée, de saisir un avenir probable pour agir dans le présent. Chaque contexte, chaque époque, chaque territoire, chaque communauté appréhende les dangers selon ses ressources culturelles d’une part, et selon les enjeux politiques, sociaux et économiques qui la traversent d’autre part. Le risque est un fait de culture, reflétant la façon dont la société se représente elle-même, envisage les phénomènes qui la menacent et définit l’altérité qui la borne. Des historiens de tous horizons ont recours, dans ces pages, au concept de risque pour comprendre le passé, pour examiner leur objet de recherche sous un angle différent, qu’il s’agisse d’histoire des sciences et techniques ou du droit, ou d’histoire environnementale, sociale ou politique. Cette démarche commune dévoile des convergences insoupçonnées et permet aux auteurs de renouer avec un problème d’une intelligibilité historique globale, problème crucial qui a pourtant été abandonné par la très grande majorité des historiens au cours des dernières décennies