11 research outputs found
Effect of Abiotic Environmental Factors on Growth and Essential Oil Characteristics of Perovskia abrotanoides
Student Surrogation in Behavioural Business Research: A Review and Decision Process Model
Are Motor Control and Regulation Problems Part of the ASD Motor Profile? A Handwriting Study
Fluid flow in pachuca (air-agitated) tanks: Part I. Laboratory-scale experimental measurements
Effectiveness of exogenous salicylic acid on root and shoot growth attributes, productivity, and water use efficiency of water-deprived fennel genotypes
No Sustained Effect of Aerobic or Resistance Training on Insulin Sensitivity in Nonobese, Healthy Older Women
A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study.
A family history of coronary artery disease (CAD), especially when the disease occurs at a young age, is a potent risk factor for CAD. DNA collection in families in which two or more siblings are affected at an early age allows identification of genetic factors for CAD by linkage analysis. We performed a genomewide scan in 1,168 individuals from 438 families, including 493 affected sibling pairs with documented onset of CAD before 51 years of age in men and before 56 years of age in women. We prospectively defined three phenotypic subsets of families: (1) acute coronary syndrome in two or more siblings; (2) absence of type 2 diabetes in all affected siblings; and (3) atherogenic dyslipidemia in any one sibling. Genotypes were analyzed for 395 microsatellite markers. Regions were defined as providing evidence for linkage if they provided parametric two-point LOD scores >1.5, together with nonparametric multipoint LOD scores >1.0. Regions on chromosomes 3q13 (multipoint LOD = 3.3; empirical P valu