12 research outputs found
The Subaru Coronagraphic Extreme Adaptive Optics system: enabling high-contrast imaging on solar-system scales
The Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument is a
multipurpose high-contrast imaging platform designed for the discovery and
detailed characterization of exoplanetary systems and serves as a testbed for
high-contrast imaging technologies for ELTs. It is a multi-band instrument
which makes use of light from 600 to 2500nm allowing for coronagraphic direct
exoplanet imaging of the inner 3 lambda/D from the stellar host. Wavefront
sensing and control are key to the operation of SCExAO. A partial correction of
low-order modes is provided by Subaru's facility adaptive optics system with
the final correction, including high-order modes, implemented downstream by a
combination of a visible pyramid wavefront sensor and a 2000-element deformable
mirror. The well corrected NIR (y-K bands) wavefronts can then be injected into
any of the available coronagraphs, including but not limited to the phase
induced amplitude apodization and the vector vortex coronagraphs, both of which
offer an inner working angle as low as 1 lambda/D. Non-common path, low-order
aberrations are sensed with a coronagraphic low-order wavefront sensor in the
infrared (IR). Low noise, high frame rate, NIR detectors allow for active
speckle nulling and coherent differential imaging, while the HAWAII 2RG
detector in the HiCIAO imager and/or the CHARIS integral field spectrograph
(from mid 2016) can take deeper exposures and/or perform angular, spectral and
polarimetric differential imaging. Science in the visible is provided by two
interferometric modules: VAMPIRES and FIRST, which enable sub-diffraction
limited imaging in the visible region with polarimetric and spectroscopic
capabilities respectively. We describe the instrument in detail and present
preliminary results both on-sky and in the laboratory.Comment: Accepted for publication, 20 pages, 10 figure
SCExAO: First Results and On-Sky Performance
We present new on-sky results for the Subaru Coronagraphic Extreme Adaptive Optics imager (SCExAO) verifying and quantifying the contrast gain enabled by key components: the closed-loop coronagraphic low-order wavefront sensor (CLOWFS) and focal plane wavefront control ("speckle nulling"). SCExAO will soon be coupled with a high-order, Pyramid wavefront sensor which will yield > 90% Strehl ratio and enable 106 -107 contrast at small angular separations allowing us to image gas giant planets at solar system scales. Upcoming instruments like VAMPIRES, FIRST, and CHARIS will expand SCExAO’s science capabilities
Development and recent results from the Subaru coronagraphic extreme adaptive optics system
The Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument is one of a handful of extreme adaptive optics systems set to come online in 2014. The extreme adaptive optics correction is realized by a combination of precise wavefront sensing via a non-modulated pyramid wavefront sensor and a 2000 element deformable mirror. This system has recently begun on-sky commissioning and was operated in closed loop for several minutes at a time with a loop speed of 800 Hz, on ~150 modes. Further suppression of quasi-static speckles is possible via a process called "speckle nulling" which can create a dark hole in a portion of the frame allowing for an enhancement in contrast, and has been successfully tested on-sky. In addition to the wavefront correction there are a suite of coronagraphs on board to null out the host star which include the phase induced amplitude apodization (PIAA), the vector vortex, 8 octant phase mask, 4 quadrant phase mask and shaped pupil versions which operate in the NIR (y-K bands). The PIAA and vector vortex will allow for high contrast imaging down to an angular separation of 1 λ/D to be reached; a factor of 3 closer in than other extreme AO systems. Making use of the left over visible light not used by the wavefront sensor is VAMPIRES and FIRST. These modules are based on aperture masking interferometry and allow for sub-diffraction limited imaging with moderate contrasts of ~100-1000:1. Both modules have undergone initial testing on-sky and are set to be fully commissioned by the end of 2014
Protective Effect of Hydroxysafflor Yellow A on Inflammatory Injury in Chronic Obstructive Pulmonary Disease Rats
Auto-antibodies to vascular endothelial cadherin in humans: association with autoimmune diseases
International audienceTo identify patients with autoimmune diseases who are at high risk of developing vascular cell dysfunction, early biomarkers must be identified. This study was designed to detect and characterize circulating autoantibodies to VE-cadherin (AAVEs) in patients with early-stage autoimmune diseases. An enzyme-linked immunosorbent assay (ELISA) was developed to capture autoantibodies, using a recombinant human VE-cadherin fragment covering the extracellular domains as a target antigen. AAVEs specificity for the target antigen was confirmed by western blotting. Basal AAVEs levels were determined for healthy donors (n=75). Sera from patients (n=100) with various autoimmune diseases, including rheumatoid arthritis (n=23), systemic lupus erythematosus (SLE, n=31), systemic sclerosis (n=30), and Behçet's disease (BD, n=16) were also tested. Levels of AAVEs were significantly higher in rheumatoid arthritis (P<0.0001), SLE (P<0.05), and BD (P<0.05) populations than in healthy subjects. Purified immunoglobulin G (IgG) from a BD patient with exceptionally high AAVEs levels recognized the EC1-4 fragment in western blots. Further characterization of the epitopes recognized by AAVEs showed that BD patients had antibodies specific for the EC3 and EC4 domains, whereas SLE patients preferentially recognized the EC1 fragment. This suggests that distinct epitopes of human VE-cadherin might be recognized in different immune diseases. Purified IgG from BD patients was found to induce endothelial cell retraction, redistribution of VE-cadherin, and cause the formation of numerous intercellular gaps. Altogether, these data demonstrate a potential pathogenic effect of AAVEs isolated from patients with dysimmune disease. This is the first description of AAVEs in humans. Because regions EC1 and EC3-4 have been shown to be involved in homophilic VE-cadherin interactions, AAVEs produced in the course of dysimmune diseases might be specific biomarkers for endothelial injury, which is part of the early pathogenicity of these diseases
Status of the SCExAO instrument: recent technology upgrades and path to a system-level demonstrator for PSI
Instrumentatio