Quantum engineering of atomic phase-shifts in optical clocks

Quantum engineering of time-separated Raman laser pulses in three-level systems is presented to produce an ultra-narrow optical transition in bosonic alkali-earth clocks free from light shifts and with a significantly reduced sensitivity to laser parameter fluctuations. Based on a quantum artificial complex-wave-function analytical model, and supported by a full density matrix simulation including a possible residual effect of spontaneous emission from the intermediate state, atomic phase-shifts associated to Ramsey and Hyper-Ramsey two-photon spectroscopy in optical clocks are derived. Various common-mode Raman frequency detunings are found where the frequency shifts from off-resonant states are canceled, while strongly reducing their uncertainties at the 10$^{-18}$ level of accuracy.Comment: accepted for publication in PR

Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine and 1-(2'-deoxy-

From a selection of 25 antiviral compounds with specific anti-herpes activity or broad-spectrum antiviral properties, two compounds, namely (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil, appeared particularly effective in inhibiting the cytopathogenicity of seal herpesvirus (phocid herpesvirus 1)

The Synthesis and Antiviral Properties of 8- Amino-3- [(2 hydroxyethoxy)methyl]-1,2,4-triazolo- [4,3-a ]pyrazine

The preparation of 8-amino-3-[(2-hydroxyethoxy)methyl]-1,2,4- triazolo[4,3-a]pyrazine (IV) as an analogue of 9-[(2-hydroxyethoxy) methyl]guanine and 9-(S)-(2,3-dihydroxypropyl)adenine is described from the reaction of 3-chloro-2-hydrazinopyrazine (V) and ethyl 2-(2-acetoxyethoxy)thioacetimidate (IXg) followed by treatment with ammonia. Compound IV was found to lack antiviral properties towards herpes simplex I and II, vaccinia virus, vesicular stomatitis virus, measles, reovirus type 1, parainfluenza virus type 3, Sindbis virus, Coxsackie type B4 virus, and poliovirus type