USCID/EWRI conference

Presented at the 2002 USCID/EWRI conference, Energy, climate, environment and water - issues and opportunities for irrigation and drainage on July 9-12 in San Luis Obispo, California.Includes bibliographical references.Calibration equations for free-flowing radial gates typically provide sufficient accuracy for irrigation district operations. However, many districts have difficulty in determining accurate discharges when the downstream water level begins to submerge the gate. Based on laboratory studies, we have developed a new calibration method for free-flowing and submerged radial gates that allows for multiple gates and widely varying upstream and downstream channel conditions. The method uses the energy equation on the upstream side of the structure and the momentum equation on the downstream side. An iterative solution is required to solve these two equations, but this allows calibration from free flow to submerged flow right through the transition. Adjustments to the energy equation for free flow are described, along with an additional energy adjustment for the transition to submerged flow. An application is used to describe the new procedure and how it overcomes the limitations of current energy-based methods

SACMAN automated canal control system

Presented during the Third international conference on irrigation and drainage held March 30 - April 2, 2005 in San Diego, California. The theme of the conference was "Water district management and governance."Includes bibliographical references.Many irrigation districts currently operate their main canals, pumping plants, etc. remotely with Supervisory Control and Data Acquisition (SCADA) software. This is usually manual operation with perhaps a few local automatic control features. SacMan (software for automated canal management) is a software package that adds canal automation logic to commercially-available, windows-based SCADA packages. It allows the user to implement a variety of automatic control features, including complete automatic control, where feasible. It was developed through research at the U.S. Water Conservation Laboratory in Phoenix, AZ. SacMan has several levels of implementation ranging from manual control to full automatic control, including upstream level control, flow rate control, routing of known demand changes, and full (distant) downstream level control. SacMan interfaces with commercial Supervisory Control and Data Acquisition (SCADA) software, currently iFix by GE Fanuc (formerly Intellution, Inc.), but potentially applicable to other SCADA packages. SacMan was field tested on the WM lateral canal at the Maricopa Stanfield Irrigation and Drainage District (MSIDD) in central Arizona. In July/August 2004, SacMan successfully operated the WM canal for a period of 30 days, nearly continuously. This paper describes the features of this canal automation software and some results from this long-term testing.Sponsored by USCID; co-sponsored by Association of California Water Agencies and International Network for Participatory Irrigation Management

Stabilization and control system power sensitivity study

Stabilization and control system sensitivity to power-off failure rate studied by simulated missions using block power switchin

Flumes and weirs

Presented at the 2002 USCID/EWRI conference, Energy, climate, environment and water - issues and opportunities for irrigation and drainage on July 9-12 in San Luis Obispo, California.Includes bibliographical references.Long-throated flumes and broad-crested weirs provide a practical, low-cost, flexible means of measuring open-channel flows in new and existing irrigation systems and have distinct advantages over other flume and weir devices. Application of these flumes and weirs has been greatly facilitated by the 1999 release of the WinFlume software used to design and calibrate these structures, and the recent publication of Water Measurement with Flumes and Weirs, a text providing comprehensive information on design, calibration, construction, and operation issues. The primary advantages of these flumes and weirs are that they can be custom-designed to satisfy unique operational and site requirements, and they can be computer calibrated without the need for laboratory testing. In addition, these devices are easily and economically constructed, and a number of commercially built, pre-calibrated devices are available. This paper and accompanying poster describe the use of the WinFlume software and present examples to illustrate application to a range of situations, including various flow rates, channel types, and construction techniques

3α,7-dihydroxy-14(13→12)abeo-5β,12α(H),13β(H)-cholan-24-oic acids display neuroprotective properties in common forms of Parkinson’s disease

Parkinson’s Disease is the most common neurodegenerative movement disorder globally, with prevalence increasing. There is an urgent need for new therapeutics which are disease-modifying rather than symptomatic. Mitochondrial dysfunction is a well-documented mechanism in both sporadic and familial Parkinson’s Disease. Furthermore, ursodeoxycholic acid (UDCA) has been identified as a bile acid which leads to increased mitochondrial function in multiple in vitro and in vivo models of Parkinson’s Disease. Here, we describe the synthesis of novel C-nor-D-homo bile acid derivatives and the 12-hydroxy-methylated derivative of lagocholic acid (7) and their biological evaluation in fibroblasts from patients with either sporadic or LRRK2 mutant Parkinson’s Disease. These compounds boost mitochondrial function to a similar level or above that of UDCA in many assays; notable, however, is their ability to boost mitochondrial function to a higher level and at lower concentrations than UDCA specifically in the fibroblasts from LRRK2 patients. Our study indicates that novel bile acid chemistry could lead to the development of more efficacious bile acids which increase mitochondrial function and ultimately cellular health at lower concentrations proving attractive potential novel therapeutics for Parkinson’s Disease