498 research outputs found
The 4 K outer cryostat for the CUORE experiment: construction and quality control
The external shell of the CUORE cryostat is a large cryogen-free system
designed to host the dilution refrigerator and the bolometers of the CUORE
experiment in a low radioactivity environment. The three vessels that form the
outer shell were produced and delivered to the Gran Sasso underground
Laboratories in July 2012. In this paper, we describe the production techniques
and the validation tests done at the production site in 2012.Comment: 11 pages, 13 figures; to appear in NIM
Usefulness of regional right ventricular and right atrial strain for prediction of early and late right ventricular failure following a left ventricular assist device implant: A machine learning approach
Background: Identifying candidates for left ventricular assist device surgery at risk of right ventricular failure remains difficult. The aim was to identify the most accurate predictors of right ventricular failure among clinical, biological, and imaging markers, assessed by agreement of different supervised machine learning algorithms. Methods: Seventy-four patients, referred to HeartWare left ventricular assist device since 2010 in two Italian centers, were recruited. Biomarkers, right ventricular standard, and strain echocardiography, as well as cath-lab measures, were compared among patients who did not develop right ventricular failure (N = 56), those with acute–right ventricular failure (N = 8, 11%) or chronic–right ventricular failure (N = 10, 14%). Logistic regression, penalized logistic regression, linear support vector machines, and naïve Bayes algorithms with leave-one-out validation were used to evaluate the efficiency of any combination of three collected variables in an “all-subsets” approach. Results: Michigan risk score combined with central venous pressure assessed invasively and apical longitudinal systolic strain of the right ventricular–free wall were the most significant predictors of acute–right ventricular failure (maximum receiver operating characteristic–area under the curve = 0.95, 95% confidence interval = 0.91–1.00, by the naïve Bayes), while the right ventricular–free wall systolic strain of the middle segment, right atrial strain (QRS-synced), and tricuspid annular plane systolic excursion were the most significant predictors of Chronic-RVF (receiver operating characteristic–area under the curve = 0.97, 95% confidence interval = 0.91–1.00, according to naïve Bayes). Conclusion: Apical right ventricular strain as well as right atrial strain provides complementary information, both critical to predict acute–right ventricular failure and chronic–right ventricular failure, respectively
Large area Si low-temperature light detectors with Neganov-Luke effect
Next generation calorimetric experiments for the search of rare events rely
on the detection of tiny amounts of light (of the order of 20 optical photons)
to discriminate and reduce background sources and improve sensitivity.
Calorimetric detectors are the simplest solution for photon detection at
cryogenic (mK) temperatures. The development of silicon based light detectors
with enhanced performance thanks to the use of the Neganov-Luke effect is
described. The aim of this research line is the production of high performance
detectors with industrial-grade reproducibility and reliability.Comment: 4 pages, 2 figure
Treatment decision making in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy: State of the art
No abstract availabl
Reducing the impact of radioactivity on quantum circuits in a deep-underground facility
As quantum coherence times of superconducting circuits have increased from
nanoseconds to hundreds of microseconds, they are currently one of the leading
platforms for quantum information processing. However, coherence needs to
further improve by orders of magnitude to reduce the prohibitive hardware
overhead of current error correction schemes. Reaching this goal hinges on
reducing the density of broken Cooper pairs, so-called quasiparticles. Here, we
show that environmental radioactivity is a significant source of nonequilibrium
quasiparticles. Moreover, ionizing radiation introduces time-correlated
quasiparticle bursts in resonators on the same chip, further complicating
quantum error correction. Operating in a deep-underground lead-shielded
cryostat decreases the quasiparticle burst rate by a factor fifty and reduces
dissipation up to a factor four, showcasing the importance of radiation
abatement in future solid-state quantum hardware
A new technique for direct investigation of dark matter
The MOSCAB experiment (Materia OSCura A Bolle) uses a new technique for Dark
Matter search. The Geyser technique is applied to the construction of a
prototype detector with a mass of 0.5 kg and the encouraging results are
reported here; an accent is placed on a big detector of 40 kg in construction
at the Milano-Bicocca University and INFN
Searches for axioelectric effect of solar axions with BGO-scintillator and BGO-bolometer detectors
A search for axioelectric absorption of 5.5 MeV solar axions produced in the
reaction has been
performed with a BGO detectors. A model-independent limit on the product of
axion-nucleon and axion-electron coupling constants has
been obtained: for 90\% C.L..Comment: 5 pages, 3 figures, Proceedings of the 10th Patras Workshop on
Axions, WIMPs and WISP 29 June - 4 July 2014, CERN, Geneva, Switzerlan
Anti-remodelling effect of canrenone in patients with mild chronic heart failure (AREA IN-CHF study): final results
AIMS: To test whether canrenone, an aldosterone receptor antagonist, improves left ventricular (LV) remodelling in NYHA class II heart failure (HF). Aldosterone receptor antagonists improve outcome in severe HF, but no information is available in NYHA class II. METHODS AND RESULTS: AREA IN-CHF is a randomized, double-blind, placebo-controlled study testing canrenone on top of optimal treatment in NYHA class II HF with low ejection fraction (EF) to assess 12-month changes in LV end-diastolic volume (LVEDV). Brain natriuretic peptide (BNP) was also measured. Information was available for 188 subjects on canrenone and 194 on placebo. Left ventricular end-diastolic volume was similarly reduced (-18%) in both arms, but EF increased more (P = 0.04) in the canrenone (from 40% to 45%) than in the placebo arm (from 40-43%). Brain natriuretic peptide (n = 331) decreased more in the canrenone (-37%) than in the placebo arm (-8%; P < 0.0001), paralleling a significant reduction in left atrial dimensions (-4% vs. 0.2%; P = 0.02). The composite endpoint of cardiac death and hospitalization was significantly lower in the canrenone arm (8% vs. 15%; P = 0.02). CONCLUSION: Canrenone on top of optimal treatment for HF did not have additional effects on LVEDV, but it increased EF, and reduced left atrial size and circulating BNP, with potential beneficial effects on outcome. A large-scale randomized study should be implemented to confirm benefits on cardiovascular outcomes in patients with HF in NYHA class I
- …