The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure

Background. The 6-minute walk test (6-MWT) is used to assess patients with chronic heart failure (CHF). The prognostic significance of the 6-MWT distance during long-term followup ( > 5 years) is unclear. Methods. 1,667 patients (median [inter-quartile range, IQR]) (age 72 [65-77] ; 75% males) with heart failure due to left ventricular systolic impairment undertook a 6-MWT as part of their baseline assessment and were followed up for 5 years. Results. At 5 years' followup, those patients who died (n = 959) were older at baseline and had a higher log NT pro-BNP than those who survived to 5 years (n = 708). 6-MWT distance was lower in those who died [163 (153) m versus 269 (160) m; P 360 m. 6-MWT distance was a predictor of all-cause mortality (HR 0.97; 95% CI 0.96-0.97; Chi-square = 184.1; P < 0.0001). Independent predictors of all-cause mortality were decreasing 6-MWT distance, increasing age, increasing NYHA classification, increasing log NT pro-BNP, decreasing diastolic blood pressure, decreasing sodium, and increasing urea. Conclusion. The 6-MWT is an important independent predictor of all-cause mortality following long-term followup in patients with CHF. © 2014 Lee Ingle et al

Tablet computers in assessing performance in a high stakes exam : opinion matters

The authors would like to thank Dr Craig brown, University of Aberdeen for assistance with data analysis.Peer reviewedPublisher PD

Metastability and the Casimir Effect in Micromechanical Systems

Electrostatic and Casimir interactions limit the range of positional stability of electrostatically-actuated or capacitively-coupled mechanical devices. We investigate this range experimentally for a generic system consisting of a doubly-clamped Au suspended beam, capacitively-coupled to an adjacent stationary electrode. The mechanical properties of the beam, both in the linear and nonlinear regimes, are monitored as the attractive forces are increased to the point of instability. There "pull-in" occurs, resulting in permanent adhesion between the electrodes. We investigate, experimentally and theoretically, the position-dependent lifetimes of the free state (existing prior to pull-in). We find that the data cannot be accounted for by simple theory; the discrepancy may be reflective of internal structural instabilities within the metal electrodes.Comment: RevTex, 4 pages, 4 figure

Clinical trials with endothelin receptor antagonists: What went wrong and where can we improve?

In the early 1990s, within three years of cloning of endothelin receptors, orally active endothelin receptor antagonists (ERAs) were tested in humans and the first clinical trial of ERA therapy in humans was published in 1995. ERAs were subsequently tested in clinical trials involving heart failure, pulmonary arterial hypertension, resistant arterial hypertension, stroke/subarachnoid hemorrhage and various forms of cancer. The results of most of these trials – except those for pulmonary arterial hypertension and scleroderma-related digital ulcers – were either negative or neutral. Problems with study design, patient selection, drug toxicity, and drug dosing have been used to explain or excuse failures. Currently, a number of pharmaceutical companies who had developed ERAs as drug candidates have discontinued clinical trials or further drug development. Given the problems with using ERAs in clinical medicine, at the Twelfth International Conference on Endothelin in Cambridge, UK, a panel discussion was held by clinicians actively involved in clinical development of ERA therapy in renal disease, systemic and pulmonary arterial hypertension, heart failure, and cancer. This article provides summaries from the panel discussion as well as personal perspectives of the panelists on how to proceed with further clinical testing of ERAs and guidance for researchers and decision makers in clinical drug development on where future research efforts might best be focused

Design and usage of the HeartCycle education and coaching program for patients with heart failure

Background: Heart failure (HF) is common, and it is associated with high rates of hospital readmission and mortality. It is generally assumed that appropriate self-care can improve outcomes in patients with HF, but patient adherence to many self-care behaviors is poor. Objective: The objective of our study was to develop and test an intervention to increase self-care in patients with HF using a novel, online, automated education and coaching program. Methods: The online automated program was developed using a well-established, face-to-face, home-based cardiac rehabilitation approach. Education is tailored to the behaviors and knowledge of the individual patient, and the system supports patients in adopting self-care behaviors. Patients are guided through a goal-setting process that they conduct at their own pace through the support of the system, and they record their progress in an electronic diary such that the system can provide appropriate feedback. Only in challenging situations do HF nurses intervene to offer help. The program was evaluated in the HeartCycle study, a multicenter, observational trial with randomized components in which researchers investigated the ability of a third-generation telehealth system to enhance the management of patients with HF who had a recent (&lt;60 days) admission to the hospital for symptoms or signs of HF (either new onset or recurrent) or were outpatients with persistent New York Heart Association (NYHA) functional class III/IV symptoms despite treatment with diuretic agents. The patients were enrolled from January 2012 through February 2013 at 3 hospital sites within the United Kingdom, Germany, and Spain. Results: Of 123 patients enrolled (mean age 66 years (SD 12), 66% NYHA III, 79% men), 50 patients (41%) reported that they were not physically active, 56 patients (46%) did not follow a low-salt diet, 6 patients (5%) did not restrict their fluid intake, and 6 patients (5%) did not take their medication as prescribed. About 80% of the patients who started the coaching program for physical activity and low-salt diet became adherent by achieving their personal goals for 2 consecutive weeks. After becoming adherent, 61% continued physical activity coaching, but only 36% continued low-salt diet coaching. Conclusions: The HeartCycle education and coaching program helped most nonadherent patients with HF to adopt recommended self-care behaviors. Automated coaching worked well for most patients who started the coaching program, and many patients who achieved their goals continued to use the program. For many patients who did not engage in the automated coaching program, their choice was appropriate rather than a failure of the program

Performance of silicon solar cell assemblies

Solar cell assembly current-voltage characteristics, thermal-optical properties, and power performance were determined. Solar cell cover glass thermal radiation, optical properties, confidence limits, and temperature intensity effects on maximum power were discussed

Comment on "Evidence for Quantized Displacement in Macroscopic Nanomechanical Oscillators"

In a recent Letter, Gaidarzhy et al. [1] claim to have observed evidence for "quantized displacements" of a high-order mode of a nanomechanical oscillator. We contend that the methods employed by the authors are unsuitable in principle to observe such states for any harmonic mode

Phase rigidity breaking in open Aharonov-Bohm ring coupled to a cantilever

The conductance and the transmittance phase shifts of a two-terminal Aharonov-Bohm (AB) ring are analyzed in the presence of mechanical displacements due to coupling to an external can- tilever. We show that phase rigidity is broken, even in the linear response regime, by means of inelastic scattering due to phonons. Our device provides a way of observing continuous variation of the transmission phase through a two-terminal nano-electro-mechanical system (NEMS). We also propose measurements of phase shifts as a way to determine the strength of the electron-phonon coupling in NEMS.Comment: 7 pages, 8 figure