Identification of Night Eating Behaviour and Investigation into Its Characteristics in an Obese Population

Background Night Eating Syndrome (NES) was characterised in 2003 as comprising; morning anorexia, evening hyperphagia, night-time awakenings, consumption of high calorie snacks during awakenings and an absence of other eating disorders (ED). Method An identification study was conducted in a hospital–based UK obesity clinic with 81 individuals undertaking a diagnostic interview and completing a proposed screening tool. Full NES (n=7) and partial NES (n=24) individuals were combined into one Night Eating Behaviour (NEB) group (n=31) and compared to all other participants (n=50). NEB characteristics were identified through qualitative thematic analysis of interview data, based on techniques used by Grounded Theorists. NEB individuals (n=28) were compared with matched controls. In a separate prevalence study, night-eating, sleep quality and suspected Obstructive Sleep Apnoea (OSA) were estimated in 103 participants using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and a validated Night Eating Questionnaire. Correlational analysis was also performed. Results In the identification study, full NES was rare (9%). Comparison of the NEB and non-NEB group showed significant differences in mood (p=0.001), work status (p= 0.03), perceived lack of control over eating (p= 0.03) and variability in sleep duration (p25, 3.9% (n=4), based on a higher cut score of >30, poor sleep quality 74% (n= 76) and suspected OSA 32% (n= 33). A strong relationship (r = 0.55, p = < 0.001) between night-eating and poor sleep quality was found, with day-time sleepiness having no influence over this relationship. Conclusion Comparison of the study findings with new NES criteria (2010) shows poor differentiation between NES and morbid obesity. In obese populations, a shift of focus is proposed to an alternative ‘Impaired Sleep Syndrome’ of which night-eaters may be a sub-group, often with severe depression. Night-eaters also exhibit too many features of other ED for this relationship to be ignored

Underwater Vocalizations as a Tool for Studying the Distribution and Relative Abundance of Wintering Pinnipeds in the High Arctic

Recordings of the underwater vocalizations of ringed seals, bearded seals and walruses were made in the High Arctic between late March and late June 1980 and 1981, to evaluate the potential for using sub-ice vocalizations to study the distribution and relative abundance of wintering pinnipeds. Most of the calls made by these three species are identified and an initial lexicon is presented. Ringed seal vocalizations were more frequent in late April than earlier in the season or in late June, whereas the highest vocalization rates recorded for bearded seals were in late June. Vocalization rates of all three species were indicative of their distribution and relative abundance in different areas and sea ice habitat types. We conclude that underwater vocalizations have the potential for giving more precise information on the relative abundance of wintering pinnipeds than techniques previously used. It may be possible, provided the necessary information on the vocal behaviour of these species is acquired, to use this technique for censusing.Key words: vocalizations, ringed seal, bearded seal, walrus, distributionMots cl&eacute;s: vocalisations, phoque annel&eacute;, phoque barbu, morse, distributio

Pattern of Local Recurrence After Conservative Surgery and Radiotherapy for Soft Tissue Sarcoma

Purpose: Over the past three decades our centre has adopted a policy of conservative surgery followed by adjuvant radicaldose radiotherapy for medium-and high-grade soft tissue sarcomas. For all cases of local recurrence following this treatment we aimed to define the spatial relationship between sites of recurrence and the positions of the phase 1 and 2 radiotherapy volumes

Physical Activity Policy for Older Adults in the Northwest Territories, Canada: Gaps and Opportunities for Gains

In the Northwest Territories (NWT), Canada, the population of older adults is increasing, and this population reports much poorer health than other age cohorts. Given the number of benefits that physical activity (PA) can have for older adults, we analyzed policies concerning older adults and PA of both the NWT government and non-governmental organizations in the health, recreation, and sports sectors. Our findings indicate that although the majority of the organizations had no PA policies specific to older adults or Aboriginal older adults, some organizations completed all five stages of the policy cycle (agenda setting, policy formulation, decision making, implementation, and evaluation). Our analysis suggests that PA for older adults is not on the agenda for many organizations in the NWT and that often the policy process does not continue past the decision-making stage. To address the need for connections between all stages of the policy cycle, we suggest that organizations collaborate across multiple sectors and with older adults to develop a territory-wide, age-friendly rural and remote community strategy that is applicable to the NWT. Prioritizing age-friendly communities would, in turn, facilitate appropriate PA opportunities for older adults in the NWT and thus contribute to a healthier aging population.Dans les Territoires du Nord-Ouest (T.N.-O.), au Canada, la population de personnes âgées augmente, et la santé de ce segment de population est bien inférieure à celle des autres segments. Étant donné les bienfaits que peut comporter l’activité physique (AP) chez les personnes âgées, nous avons analysé les politiques concernant les personnes âgées et l’AP au sein des organismes gouvernementaux et non gouvernementaux des Territoires du Nord-Ouest en matière de santé, de loisirs et de sports. Nos constatations indiquent que même si la majorité des organismes n’étaient pas dotés de politiques d’AP visant particulièrement les personnes âgées ou les Autochtones âgés, certains organismes avaient déjà fait les cinq étapes du cycle stratégique (détermination de l’ordre du jour, formulation de politiques, prise de décisions, mise en oeuvre et évaluation). Notre analyse suggère que pour bien des organismes des T.N.-O., l’AP chez les personnes âgées ne figure pas au programme et que souvent, le processus d’élaboration de politiques ne se poursuit pas après l’étape de la prise de décisions. Afin de relier toutes les étapes du cycle, nous suggérons que les organismes des divers secteurs collaborent entre eux ainsi qu’avec les personnes âgées afin de parvenir à une stratégie qui correspond bien aux gens plus âgés des localités rurales et éloignées, à l’échelle des T.N.-O. En accordant une priorité à la création de collectivités qui tiennent compte des personnes âgées, on pourrait aboutir à des activités physiques convenant aux personnes âgées des T.N.-O., ce qui contribuerait à une population vieillissante en meilleure santé

H. Stuart Innes (1953-2000)

Dr. Stuart Innes (Canada Department of Fisheries and Oceans), along with Dr. Malcolm Ramsay (University of Saskatchewan), died in a helicopter crash near Resolute Bay, Nunavut, on 21 May 2000. Both Stu and Malcolm are remembered with affection and admiration for their boundless energy and devotion to their scientific endeavours in the Arctic. Those of us at the Department of Fisheries and Oceans (DFO) remember Stu as an outspoken and talented scientist who loved the Arctic. His research interests were diverse and included population ecology and modeling, reproduction and physiology, genetics, and contaminants. He authored and co-authored numerous papers for various journals and other publications. He was also a leader on international, national, and regional projects and committees. ... Stu spent three to four months a year conducting research in remote Arctic field camps. He had great respect for the people of the North and their land. This respect revealed itself in many ways, including his ongoing efforts to learn Inuktitut. ... He frequently lived and worked alongside Inuit, and he understood and promoted the value of incorporating their knowledge and experience into scientific studies. Stuart had a highly inquisitive mind and a real appetite for life. His joys were simple: good friends, dedicated colleagues, and the loyal companionship of his dogs. His sudden passing is a great loss to his family, friends, and colleagues. He will long be remembered by all those fortunate enough to have known him

Exploring the clinical benefits of novel radiotherapy system HalcyonTM – a narrative review of the evidence

Abstract: Exploring the clinical benefits of novel radiotherapy system HalcyonTM – a narrative review of the evidence Introduction Approximately 50% of all cancer patients receive external beam radiotherapy (EBRT)1. A novel O-ring treatment delivery system, HalcyonTM, was released in 20172. Gantry rotation can be legally faster (for both treatment and imaging) due to being enclosed2. With a stacked/staggered higher leaf speed MLC, both on-treatment imaging and delivery can be quicker with potential improvements in plan quality, clinical outcomes, and patient experience3. This poster will focus on one of the clinical outcomes explored in this review: early-disease control. Since loco-regional failure rates correlate strongly with the incidence of overall survival, measuring early disease control may give an indication of whether improved clinical outcomes are now being realised4. Method A narrative review was conducted using the online database PubMed. Key search-terms used were as follows; ‘’Halcyon’’, ‘’O-ring linac’’ ‘’toxicit*’’, ‘’treatment time’’ and ‘’clinical’’. Inclusion and exclusion criteria were used to tighten focus onto studies identifying reported clinical results. The selected studies were analysed, appraised, and critiqued using Preferred Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and CASP methods. Results The final 11 papers included discussed clinical outcomes, including acute toxicities and early disease control, and the logistical metric, treatment delivery time. From these, 2 studies reported on early-disease control in terms of local, regional, and distant failures. The early-disease control for 16 patients with gynaecological cancers, showed local and regional failure rates of 6.25%, a distant failure rate of 12.5% and a mortality rate of 6.25%, with maximum follow-up of 7.1 months5; all comparable to published, larger trials in which patients had received EBRT on standard C-arm linacs6. Differences between trials included variability in follow-up time, cohort size and disease progression. The early-disease control for 30 lung cancer patients treated on HalcyonTM showed local, regional, and distant failure rates of 6%, 16% and 26%, respectively, with a mortality rate of 23%7. This study had a maximum follow-up time of 10.9 months; making like-for-like comparisons with published evidence (which usually reported at 12/24 months) difficult. Conclusion Our results show that early clinical outcomes using HalcyonTM are promising, however, future work should strive to define and measure clinical outcomes in a more standardised and consistent way. Further follow-up of patients treated on HalcyonTM is necessary and it is potentially still too early to quantify exactly how local control rates compare to that of standardised C-arm linac IMRT/VMAT techniques

Baffin Bay Narwhal Population Distribution and Numbers: Aerial Surveys in the Canadian High Arctic, 2002–04

Aerial surveys of narwhals (Monodon monoceros) were conducted in the Canadian High Arctic during the month of August from 2002 to 2004. The surveys covered the waters of Barrow Strait, Prince Regent Inlet, the Gulf of Boothia, Admiralty Inlet, Eclipse Sound, and the eastern coast of Baffin Island, using systematic sampling methods. Fiords were flown along a single transect down the middle. Near-surface population estimates increased by 1.9 %– 8.7% when corrected for perception bias. The estimates were further increased by a factor of approximately 3, to account for individuals not seen because they were diving when the survey plane flew over (availability bias). These corrections resulted in estimates of 27 656 (SE = 14 939) for the Prince Regent and Gulf of Boothia area, 20 225 (SE = 7285) for the Eclipse Sound area, and 10 073 (SE = 3123) for the East Baffin Island fiord area. The estimate for the Admiralty Inlet area was 5362 (SE = 2681) but is thought to be biased. Surveys could not be done in other known areas of occupation, such as the waters of the Cumberland Peninsula of East Baffin, and channels farther west of the areas surveyed (Peel Sound, Viscount Melville Sound, Smith Sound and Jones Sound, and other channels of the Canadian Arctic archipelago). Despite these probable biases and the incomplete coverage, results of these surveys show that the summering range of narwhals in the Canadian High Arctic is vast. If narwhals are philopatri to their summering areas, as they appear to be, the total population of that range could number more than 60 000 animals. The largest numbers are in the western portion of their summer range, around Somerset Island, and also in the Eclipse Sound area. However, these survey estimates have large variances due to narwhal aggregation in some parts of the surveyed areas.Des levés aériens ont été effectués dans l’Extrême arctique canadien dans le but de répertorier les populations de narvals (Monodon monoceros) et ce, du mois d’août 2002 à août 2004. Les levés, réalisés à l’aide de méthodes d’échantillonnage systémiques, visaient les eaux du détroit de Barrow, de l’inlet Prince-Régent, du golfe de Boothia, de l’inlet de l’Amirauté, du détroit d’Éclipse et de la côte est de l’île de Baffin. Les fiords ont été survolés le long d’un simple transect situé dans le milieu. Les estimations de population près de la surface augmentaient de 1,9 % à 8,7 % une fois redressées pour tenir compte du biais de perception. Par ailleurs, les estimations ont été de nouveau révisées à la hausse moyennant un facteur d’environ 3 afin de tenir compte des individus qui n’ont pas été vus parce qu’ils se mettaient à plonger en présence de l’avion effectuant les levés (biais de disponibilité). Ces redressements ont donné lieu à des estimations de 27 656 (SE = 14 939) pour la région de l’inlet Prince-Régent et du golfe de Boothia, de 20 225 (SE = 7 285) pour la région du détroit d’Éclipse et de 10 073 (SE = 3 123) pour la région du fiord de l’est de l’île de Baffin. Quand à l’inlet de l’Amirauté, l’estimation s’est chiffrée à 5 362 (SE = 2 681), mais l’on croit que cette estimation pourrait être biaisée. Des levés n’ont pas pu être effectués dans d’autres zones d’occupation connues, comme dans les eaux de la péninsule Cumberland dans l’est de Baffin de même que dans les chenaux plus à l’ouest des régions examinées (détroit de Peel, détroit du Vicomte de Melville, détroit de Smith, détroit de Jones et d’autres chenaux de l’archipel Arctique canadien). Malgré la possibilité que les données soient biaisées et que certaines zones n’aient pas été examinées, les résultats de ces levés montrent que la répartition d’été des narvals dans l’Extrême arctique canadien est vaste. Si les narvals sont philopatriques à leurs aires d’été, comme il semblerait être le cas, la population totale de ce parcours pourrait dépasser les 60 000 individus. Les plus grands nombres se trouvent dans la partie ouest de cette répartition, soit près de l’île Somerset et dans la région du détroit d’Éclipse. Cependant, les estimations découlant de ces levés ont de grandes variances en raison du regroupement des narvals dans certaines parties des régions visées par les levés

A method for generating coherent spatially explicit maps of seasonal palaeoclimates from site-based reconstructions

We describe a method for reconstructing spatially explicit maps of seasonal palaeoclimate variables from site-based reconstructions. Using a 3D-Variational technique, the method finds the best statistically unbiased, and spatially continuous, estimate of the palaeoclimate anomalies through combining the site-based reconstructions and a prior estimate of the palaeoclimate state. By assuming a set of correlations in the error of the prior, the resulting climate is smoothed both from month to month and from grid cell to grid cell. The amount of smoothing can be controlled through the choice of two length-scale values. The method is applied to a set of reconstructions of the climate of the Last Glacial Maximum (ca. 21,000 years ago, yr BP) for southern Europe derived from pollen data with a prior derived from results from the third phase of the Palaeoclimate Intercomparison Project (PMIP3). We demonstrate how to choose suitable values for the smoothing length scales from the datasets used in the reconstruction

Clinical translation of [18F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer

Background: Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [18F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have favourable dosimetry, safety, and biodistribution. We report the translation of [18F]ICMT-11 PET to measure chemotherapy-induced caspase-3/7 activation in breast and lung cancer patients receiving first-line therapy. Results: Breast tumour SUVmax of [18F]ICMT-11 was low at baseline and unchanged following therapy. Measurement of M30/M60 cytokeratin-18 cleavage products showed that therapy was predominantly not apoptosis in nature. While increases in caspase-3 staining on breast histology were seen, post-treatment caspase-3 positivity values were only approximately 1%; this low level of caspase-3 could have limited sensitive detection by [18F]ICMT-11-PET. Fourteen out of 15 breast cancer patients responded to first–line chemotherapy (complete or partial response); one patient had stable disease. Four patients showed increases in regions of high tumour [18F]ICMT-11 intensity on voxel-wise analysis of tumour data (classed as PADS); response was not exclusive to patients with this phenotype. In patients with lung cancer, multi-parametric [18F]ICMT-11 PET and MRI (diffusion-weighted- and dynamic contrast enhanced-MRI) showed that PET changes were concordant with cell death in the absence of significant perfusion changes. Conclusion: This study highlights the potential use of [18F]ICMT-11 PET as a promising candidate for non-invasive imaging of caspase3/7 activation, and the difficulties encountered in assessing early-treatment responses. We summarize that tumour response could occur in the absence of predominant chemotherapy-induced caspase-3/7 activation measured non-invasively across entire tumour lesions in patients with breast and lung cancer

Statistical expression deconvolution from mixed tissue samples

Motivation: Global expression patterns within cells are used for purposes ranging from the identification of disease biomarkers to basic understanding of cellular processes. Unfortunately, tissue samples used in cancer studies are usually composed of multiple cell types and the non-cancerous portions can significantly affect expression profiles. This severely limits the conclusions that can be made about the specificity of gene expression in the cell-type of interest. However, statistical analysis can be used to identify differentially expressed genes that are related to the biological question being studied