Reciprocal natural selection on host-parasite phenotypes

Journal ArticleCoevolution is evolution in one species in response to selection imposed by a second species, followed by evolution in the second species in response to reciprocal selection imposed by the first species. Although reciprocal selection is a prerequisite of coevolution, it has seldom been documented in natural populations. We examined the feasibility of reciprocal selection in a simple host-parasite system consisting of feral pigeons (Columba livid) and their Ischnoceran feather lice (Phthiraptera: Insecta)

Reciprocal natural selection on host‐parasite phenotypes

Coevolution is evolution in one species in response to selection imposed by a second species, followed by evolution in the second species in response to reciprocal selection imposed by the first species. Although reciprocal selection is a prerequisite of coevolution, it has seldom been documented in natural populations. We examined the feasibility of reciprocal selection in a simple host‐parasite system consisting of feral pigeons (Columba livia) and their Ischnoceran feather lice (Phthiraptera: Insecta). We tested for a selective effect of parasites on hosts with experimentally altered defenses and for a selective effect of host defense on a component of parasite escape. Previous work indicates that pigeons control lice through efficient preening, while lice escape from preening using complex avoidance behavior. Our results show that feral pigeons with impaired preening, owing to slight bill deformities, have higher louse loads than pigeons with normal bills. We use a controlled experiment to show that high louse loads reduce the survival of pigeons, suggesting that lice select for efficient preening and against bill deformities. In a reciprocal experiment, we demonstrate that preening with a normal bill selects for small body size in lice, which may facilitate their escape from preening. The results of this study verify a crucial element of coevolutionary theory by identifying likely targets of reciprocal phenotypic selection between host and parasite

Partial Depth Precast Concrete Deck Panels on Curved Bridges: Finite Element Analytical Model of PCPs

Report on partial depth precast concrete deck panels on curved bridges

Considering sex as a biological variable in preclinical research

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154390/1/fsb2fj201600781r.pd

The Iowa Homemaker vol.23, no.10

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Improved Tub Girder Details: Final Report

0-6862Steel trapezoidal box girders, generally referred to as tub girders, have been widely used on a number of bridges throughout the State of Texas. The smooth profile of the girder systems provides an aesthetically appealing bridge that also possesses several structural advantages compared to other girder types. Due to the significant torsional stiffness of the closed box section, the girders are a popular choice in horizontally curved systems where the bridge geometry leads to large torsional moments. The girders have also been used on a number of straight girder systems throughout the state leading to improved bridge aesthetics. While tub girders have primarily been used on bridges with longer spans where concrete girders are not viable, an application of relatively shallow steel tub girders was recently used in the TxDOT Waco District on a bridge with span lengths normally reserved for concrete girder systems. The resulting bridge provided an aesthetically appealing structure that satisfied a demanding vertical clearance requirement and was cost-comparable with precast concrete girders. This shallow tub girder application demonstrates that steel trapezoidal box girders offer a viable alternative that should be considered for a wider variety of bridge applications. However, to augment the viability of tub girders, improved details need to be considered to further enhance their economic and structural advantages. Modifications in the girder geometry can provide more efficient systems. The objective of this research is to develop improved details for tub girders as well as design methodologies for the girders and bracing components

Fatigue Resistance and Reliability of High Mast Illumination Poles (HMIPs) with Pre-Existing Cracks: Final Report

0-6829High mast illumination poles (HMIPs) are used throughout Texas and the U.S. to provide lighting along highways and at interchanges. Texas currently has about 5000 HMIPs, varying in height from 100 to 175 ft. Failures of HMIPs have been reported in several states, attributed to failures at the shaft-to-base plate connection. No collapses of HMIPs have been reported in Texas. However, recent studies have shown that many galvanized HMIPs in Texas have pre-existing cracks at their shaft-to-base plate connection, most likely caused by the galvanization process before the poles were placed in service. Previous research has also shown that pre-existing cracks may significantly reduce the fatigue life of galvanized HMIPs. The Texas Department of Transportation (TxDOT) has identified three major issues/concerns with respect to HMIPs with pre-existing cracks: the lack of reliable experimental data about the fatigue life of pre-cracked HMIP base-connection details; the significant uncertainty regarding the natural wind response of HMIPs to the various major wind environments in Texas (much of this uncertainty is related to the lack of measured data from comprehensive field studies); and, due to this lack of data, the \u2018safe/serviceable\u2019 life of in-service TxDOT HMIPs with pre-existing cracks cannot be reliably predicted. The main goal of this research project was to generate data and information to support a probabilistic-based assessment of the remaining life of HMIPs with pre-existing cracks. The research included extensive laboratory fatigue testing of HMIPs with pre-existing cracks, field monitoring of in-service HMIPs at five locations across Texas, and the development of a reliability based framework to assess the safety of in-service HMIPs with pre-existing cracks. The results of this study show a wide range in the predicted lives of HMIPs with pre-existing cracks at different locations throughout the state. Based on a probability of failure of 5 percent, the predicted fatigue life at a number of locations analyzed throughout the state showed predicted lives varying from approximately 30 years to over 300 years. The variation in predicted lives is mainly affected by differing wind characteristics at each location

Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement

Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been studied extensively. Experimental studies showing the permissive role of GH/insulin-like growth factor 1 (IGF-I) in carcinogenesis have raised concerns regarding the safety of GH replacement in children and adults who have received treatment for cancer and those with intracranial and pituitary tumours. A consensus statement was produced to guide decision-making on GH replacement in children and adult survivors of cancer, in those treated for intracranial and pituitary tumours and in patients with increased cancer risk. With the support of the European Society of Endocrinology, the Growth Hormone Research Society convened a Workshop, where 55 international key opinion leaders representing 10 professional societies were invited to participate. This consensus statement utilized: (1) a critical review paper produced before the Workshop, (2) five plenary talks, (3) evidence-based comments from four breakout groups, and (4) discussions during report-back sessions. Current evidence reviewed from the proceedings from the Workshop does not support an association between GH replacement and primary tumour or cancer recurrence. The effect of GH replacement on secondary neoplasia risk is minor compared to host- and tumour treatment-related factors. There is no evidence for an association between GH replacement and increased mortality from cancer amongst GH-deficient childhood cancer survivors. Patients with pituitary tumour or craniopharyngioma remnants receiving GH replacement do not need to be treated or monitored differently than those not receiving GH. GH replacement might be considered in GH-deficient adult cancer survivors in remission after careful individual risk/benefit analysis. In children with cancer predisposition syndromes, GH treatment is generally contraindicated but may be considered cautiously in select patients

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods - recursive partitioning and regression - to pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A (risk ratios >1.5; Pcombined = 2.01 × 10-19 and 2.35 × 10-13, respectively) in addition to the established associations of the MHC class II genes. Other loci with smaller and/or rarer effects might also be involved, but to find these, future searches must take into account both the HLA class II and class I genes and use even larger samples. Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes. ©2007 Nature Publishing Group