Oral Aversion and Your Child\u27s Dental Health Brochure and Handout

For this A with Honors project, the student created a a caregiver brochure and a healthcare provider fact sheet to address dental healthcare concerns for children with oral aversion issues

Considerations Regarding the Digestive Development of the Premature Neonate

For most parents, adjusting to life with a typical newborn revolves around two main priorities: getting the baby sufficiently fed and watching for tell-tale signs of adequate digestion. Usually this does not involve much consideration for what is going on between the two ends of the digestive system. However, if the infant is born prematurely or needs to spend the start of life in the Neonatal Intensive Care Unit (NICU), they find themselves thrust into a foreign world where life revolves around the baby’s fluid intake & output, oxygen saturations and heart rate. At this point, a conversation about the physiological maturation of the digestive system may need to take place between parents and health care providers

Altered Nutritional Function: Nutritional Support in the Pediatric Population

This slide show introduces tube feeding to meet nutritional requirements for children with special needs

Modelling the impact of forest design plans on an endangered mammal species: The eurasian red squirrel

PublishedJournal ArticleThis is the author accepted manuscript. The final version is available from Associazione Teriologica Italiana via the DOI in this record.© 2016 Associazione Teriologica Italiana.The Eurasian red squirrel (Sciurus vulgaris) is under threat in the UK from the introduced North American grey squirrel. National measures to save the species include large conifer forest reserves where management encompasses measures to bolster the native species. However, forests are multipurpose environments and foresters have to balance different timber production, amenity and conservation objectives. We present a mathematical modelling framework that examines the impacts of potential felling and restocking plans for two reserves, Kidland and Uswayford forests, in northern England. In collaboration with forest managers, we employed an iterative process that used the model to assess four forest design plans (felling and restocking scenarios) with the aim of improving red squirrel population viability. Overall, the model predicted that extinction in both forests at the same time was rare, but high in Uswayford (84%) alone. Survival could be drastically increased (from 16% to 70%) by felling and restocking adjustments, and improving dispersal between the two adjacent forests. This study provides an exemplar of how modelling can have a direct input to land management to help managers objectively balance the differing pressures of multipurpose forestry.AW, MB and PL are supported in part by a NERC Innovations grant NE/M021319/1

Nature-based Solutions for Climate Change in the UK

Nature-based solutions (NbS) address societal problems in ways that benefit both people and nature. The main focus of this report is the joint role of NbS for addressing the climate and biodiversity crises we currently face. Natural habitats act as NbS for climate if they sequester carbon (contributing to Net Zero targets) or provide adaptation to climate change effects (for example, reducing flooding, protecting coastline against sea-level rise or creating cool spaces in cities). As well as these climate benefits, they can enhance biodiversity, create improved and more resilient ecosystem functioning, enhance human wellbeing and provide economic benefits, in terms of monetary value and job creation. Despite the huge range of benefits NbS have, they should be seen as complementary to other climate and conservation actions, not as a replacement to them. NbS have great potential to tackle the two defining crises of our age. The BES report provides examples of opportunities for NbS across a range of habitats, as well as discussion of some of the complexities involved in planning for NbS. The report also outlines a detailed analysis of the tools, financial mechanisms and policies required for effective delivery in a UK context. Policy change will be necessary to overcome some of the challenges associated with NbS and to ensure that they fulfil their potential, yet the rewards are vital in meeting national climate change and biodiversity targets. The Executive Summary provides five key themes which emerge across the report, across the multiple habitats and multiple NbS studied. Six ‘priority’ habitats for NbS are given at the end of the summary. However, we emphasise that all habitats covered in the report can act as NbS and all can play a role in addressing the climate and biodiversity crises

A Novel Function of Apolipoprotein E: Upregulation of ATP-Binding Cassette Transporter A1 Expression

Despite the well known importance of apolipoprotein (Apo) E in cholesterol efflux, the effect of ApoE on the expression of ATP-binding cassette transporter A1 (ABCA1) has never been investigated. The objective of this study was to determine the effect of ApoE on ApoB-carrying lipoprotein-induced expression of ABCA1, a protein that mediates cholesterol efflux. Our data demonstrate that ApoB-carrying lipoproteins obtained from both wild-type and ApoE knockout mice induced ApoAI-mediated cholesterol efflux in mouse macrophages, which was associated with an enhanced ABCA1 promoter activity, and an increased ABCA1 mRNA and protein expression. In addition, these lipoproteins increased the level of phosphorylated specificity protein 1 (Sp1) and the amount of Sp1 bound to the ABCA1 promoter. However, all these inductions were significantly diminished in cells treated with ApoE-free lipoproteins, when compared to those treated with wild-type lipoproteins. Enrichment with human ApoE3 reversed the reduced inducibility of ApoE-free lipoproteins. Moreover, we observed that inhibition of Sp1 DNA-binding by mithramycin A diminished ABCA1 expression and ApoAI-mediated cholesterol efflux induced by ApoB-carrying lipoproteins, and that mutation of the Sp1-binding motif in the ABCA1 promoter region diminished ApoB-carrying lipoprotein-induced ABCA1 promoter activity. Collectively, these data suggest that ApoE associated with ApoB-carrying lipoproteins has an upregulatory role on ABCA1 expression, and that induction of Sp1 phosphorylation is a mechanism by which ApoE upregulates ABCA1 expression

LE SR-BI, RECEPTEUR DES HDL (LIGANDS ET REGULATION DANS UNE LIGNEE DE CELLULES SURRNEALES HUMAINES (DOCTORAT : SCIENCES PHARMACEUTIQUES))

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

LE SR-BI, RECEPTEUR DES HDL (LIGANDS ET REGULATION DANS UNE LIGNEE DE CELLULES SURRENALES HUMAINES (DES PHARMACIE SPECIALISEE))

LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF