Efisiensi Sistem E-procurement dalam Pelelangan Umum Pengadaan Barang dan Jasa (Studi Kasus: Dinas Pekerjaan Umum Provinsi Bali)

E-procurement system in the procurement of government goods / services is essential to improve the efficiency of the procurement process, this is the purpose and principles of procurement process government goods / services, including the Public Works Department of Bali Province as one SKPD Bali Province who have used the e-procurement system in the procurement process. The purpose of this study was to determine the efficiency as well as the constraints of e-procurement system in the procurement of government goods / services performed particularly of Public Works Department of Bali Province. This type of research is using descriptive qualitative approach. Source data used are primary data and secondary data. The results of the analysis of the findings and conclusions of research are e-procurement system in the procurement of goods / services conducted by the Public Works Department of Bali Province has been run in full and more efficient than the conventional way. This is evidenced by the results of the field survey and data procurement conducted by the Public Works Department of Bali Province in particular prone years. But it need to increase the use of electronic systems in other procurement methods, as well as the development of the server to operate the system that are not easily hacked or suffer other server error, given the e-procurement system based online. So that in the future, e-procurement system will be more efficient and transparent in accordance with the principles and objectives

Analysis of nucleation using mean first-passage time data from molecular dynamics simulation

We introduce a method for the analysis of nucleation using mean first-passage time (MFPT) statistics obtained by molecular dynamics simulation. The method is based on the Becker-Döring model for the dynamics of a nucleation-mediated phase change and rigorously accounts for the system size dependence of first-passage statistics. It is thus suitable for the analysis of systems in which the separation between time scales for nucleation and growth is small, due to either a small free energy barrier or a large system size. The method is made computationally practical by an approximation of the first-passage time distribution based on its cumulant expansion. Using this approximation, the MFPT of the model can be fit to data from molecular dynamics simulation in order to estimate valuable kinetic parameters, including the free energy barrier, critical nucleus size, and monomer attachment pre-factor, as well as the steady-state rates of nucleation and growth. The method is demonstrated using a case study on nucleation of n-eicosane crystals from the melt. For this system, we found that the observed distribution of first-passage times do not follow an exponential distribution at short times, rendering it incompatible with the assumptions made by some other methods. Using our method, the observed distribution of first-passage times was accurately described, and reasonable estimates for the kinetic parameters and steady-state rates of nucleation and growth were obtained

Multiferroic nature of charge-ordered rare earth manganites

Charge-ordered rare earth manganites Nd0.5Ca0.5MnO3, La0.25Nd0.25Ca0.5MnO3, Pr0.7Ca0.3MnO3 and Pr0.6Ca0.4MnO3 are found to exhibit dielectric constant anomalies around the charge-ordering or the magnetic transition temperatures. Magnetic fields have a marked effect on the dielectric properties, indicating the presence of coupling between the magnetic and electrical order parameters. The observation of magnetoferroelectricity in these manganites is in accord with the recent theoretical predictions of Khomskii and coworkers

Chlorhexidine for the treatment of fusarium keratitis:A case series and mini review

Fungal keratitis is difficult to treat, especially Fusarium keratitis. In vitro studies show that chlorhexidine could be an interesting option as monotherapy. We describe a case series of four patients (four eyes) with Fusarium keratitis at Radboud University Medical Center (Nijmegen, the Netherlands). The patients were treated with chlorhexidine 0.02% eye drops. The in vitro activity of eight antifungals and chlorhexidine was determined according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) broth microdilution method. We also reviewed the literature on the use of chlorhexidine in the treatment of fungal keratitis. Topical chlorhexidine was well tolerated, and all patients showed complete resolution of the keratitis upon treatment with chlorhexidine. A PubMed search of the available literature was conducted (last search 8 March 2020) and yielded two randomized clinical trials (natamycin versus chlorhexidine) and one case report addressing the treatment of fungal keratitis with chlorhexidine. Chlorhexidine was found to be safe with regard to toxicity and to be superior to natamycin in the clinical trials. Chlorhexidine showed in vitro fungicidal activity against Fusarium and clinical effectiveness in our cases, supporting further clinical evaluation. Advantages of chlorhexidine are its topical application, its general availability, its low costs, its broad-spectrum activity, and its fungicidal mechanism of action at low concentrations

Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021

We describe two false-negative results in the detection of meticillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 and spa type t011 using the Cepheid Xpert MRSA NxG assay. The isolates were recovered in late February and early March 2021 from two patients in different hospitals in the northern Netherlands. Variations between the two isolate genomes indicate that this MRSA strain might have been spreading for some time and could have disseminated to other regions of the Netherlands and other European countries

ANALISIS PENGANGGARAN INFRASTRUKTUR JALAN (PEMELIHARAAN, PENINGKATAN DAN PEMBANGUNAN JALAN) TERHADAP KETIMPANGAN WILAYAH DI KOTA KOTAMOBAGU

Kota Kotamobagu merupakan pusat pertumbuhan ekonomi  diwilayah Bolaang Mongondow Raya. Ketersediaan jalan merupakan salah satu urat nadi dalam pertumbuhan ekonomi wilayah karena berhubungan dengan AKSESBILITAS dan DISTRIBUSI berbagai aktivitas ekonomi para agen ekonomi          Penelitian ini bertujuan untuk mengetahui pengaruh penganggaran pada pemeliharaan jalan, peningkatan jalan dan pembangunan jalan terhadap ketimpangan wilayah di Kota Kotamobagu. Data yang digunakan adalah data sekunder yang bersumber dari instansi terkait.Metode análisis yang digunakan adalah  regresi berganda dengan model semi logaritma. Hasil penelitian membuktikan bahwa peningkatan penganggaran pada pemeliharaan jalan dan pembangunan jalan secara parsial berpengaruh signifikan terhadap penurunan ketimpangan wilayah di Kota Kotamobagu. Sedangkan penganggaran peningkatan jalan secara parsial tidak berpengaruh signifikan terhadap ketimpangan wilayah di Kota Kotamobagu. Secara Bersama-sama dibuktikan bahwa peningkatan penganggaran pada pemeliharaan jalan, peningkatan jalan  dan pembangunan jalan berpengaruh signifikan terhadap penurunan ketimpangan wilayah di Kota Kotamobagu.   Kata Kunci: Infrastruktur Jalan, pengaruh penganggaran, dan ketimpangan wilaya

Emerging pan-resistance in <i>Trichosporon </i>species:a case report

BACKGROUND: Trichosporon species are ubiquitously spread and known to be part of the normal human flora of the skin and gastrointestinal tract. Trichosporon spp. normally cause superficial infections. However, in the past decade Trichosporon spp. are emerging as opportunistic agents of invasive fungal infections, particularly in severely immunocompromised patients. Clinical isolates are usually sensitive to triazoles, but strains resistant to multiple triazoles have been reported. CASE PRESENTATION: We report a high-level pan-azole resistant Trichosporon dermatis isolate causing an invasive cholangitis in a patient after liver re-transplantation. This infection occurred despite of fluconazole and low dose amphotericin B prophylaxis, and treatment with combined liposomal amphotericin B and voriconazole failed. CONCLUSION: This case and recent reports in literature show that not only bacteria are evolving towards pan-resistance, but also pathogenic yeasts. Prudent use of antifungals is important to withstand emerging antifungal resistance