Additional file 1: of DECADE-pilot: decision aid, action planning, and follow-up support for patients to reduce the 10-year risk of cardiovascular diseases—a protocol of a randomized controlled pilot trial

Semi-structured telephone interviews with general practitioners. List of topics. (PDF 75 kb

A brief instrument to measure health-related quality-of-life in patients with bone metastasis: validation of the German version of Bone Metastases Quality-of-Life-10 (BOMET-QoL-10)

<p><b>Aims:</b> This prospective, epidemiologic study was designed to translate the original Spanish Bone Metastases Quality-of-Life-10 (BOMET-QoL-10) questionnaire and undertake a validation of the translated German version of BOMET-QoL-10 in Germany to assess health-related quality-of-life (HRQoL) in patients with bone metastases (BM).</p> <p><b>Methods:</b> The translation process included forward and backward translations, and a linguistic validation. Patients aged ≥18 years with histological confirmation of cancer, diagnosed with BM, life expectancy ≥6 months, and fluency in German were eligible for this study (enrolled consecutively in 33 outpatient centers in Germany). Patients were given the German version of BOMET-QoL-10, together with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire QLQ-C30 and EORTC QLQ-BM22 questionnaires at inclusion, 6 weeks, 3 months, and 6 months after inclusion. A debriefing questionnaire was administered at inclusion to determine patient acceptability and understanding.</p> <p><b>Results:</b> Data include 364 patients with BM (median age = 68 years; females = 71.7%). The BOMET-QoL-10 is brief and clear (median completion time = 5 minutes; >90% of patients completed the questionnaire without assistance). The BOMET-QoL-10 forms only one overall scale. All 10 items showed a substantial correlation with the first factor (factor loading, range = 0.58–0.86). BOMET-QoL-10 exhibits high internal consistency and reproducibility (Cronbach’s alpha = 0.91; intra-class correlation coefficient = 0.76). BOMET-QoL-10 showed significant correlations (range = 0.69–0.79) both with EORTC QLQ-C30 and EORTC QLQ-BM22 within the functioning (physical, social, interference) and symptom (fatigue, pain) scales, displayed significant sensitivity to change in EORTC QLQ-BM22 scores, and proved the potential ability to detect change in HRQoL in patients with different disease status.</p> <p><b>Limitations:</b> There was a high proportion of females in this study, which might represent a limitation.</p> <p><b>Conclusions:</b> The German version of BOMET-QoL-10 is a valid, reliable, brief, and clear instrument able to measure HRQoL in patients with BM.</p

O sistema tradicional de exploração de ovinos em Bragança

Este número da série Estudos reproduz parte significativa de uma tese de Mestrado apresentada na UTAD - Universidade de Trás-os-Montes e Alto Douro, em 1993, com o título Pastores, rebanhos de ovinos e pastoreio. Que futuro para o sistema tradicional de exploração. Da tese original, retirámos um capítulo, referente ao estudo da produção ovina numa aldeia do concelho de Bragança e ao estudo económico das explorações de ovinos dessa aldeia; e alguns anexos, cuja ausência não prejudicam a leitura e compreensão deste texto. Passados estes anos, o texto perdeu alguma actualidade, pois algumas das condições então analisadas sofreram alterações. Porque conhecemos a evolução entretanto verificada (o nosso trabalho de investigação, realizado entretanto, permitiu acompanhar a actividade) podemos afirmar que o texto não perdeu, nos seus aspectos fundamentais, actualidade. Podemos referir que as alterações mais importantes que se verificaram se relacionam com aspectos de legislação (por exemplo, regulamentação da actividade, posturas autárquicas); com as modificações verificadas nalguns organismos ou instituições (por exemplo, serviços ligados ao Ministério da Agricultura); alterações nas normas e regulamentos de apoio e subsídios concedidos aos criadores de ovinos. Será interessante, no futuro, fazer a comparação, relativamente a este estudo, e analisar a evolução do sistema tradicional de exploração de ovinos, e procurar encontrar as razões das alterações verificadas

Additional file 2 Table S2. of ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286)

Visit schedule Arm B (CROSS). (DOCX 25 kb